The effect of sedation and awakening on energy substrates and hormonal relationships in the subhuman primate

Arnold G. Coran; Philip E. Cryer; Jonas Sode; David L. Horwitz; Clifford M. Herman

doi:10.1016/0022-4804(73)90006-1

The effect of sedation and awakening on energy substrates and hormonal relationships in the subhuman primate

Arnold G. Coran, Philip E. Cryer, Jonas Sode, David L. Horwitz, Clifford M. Herman

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Abstract

Fifteen adult baboons were tranquilized with 1-(1-phenylcyclohexyl) piperidine hydrochloride (Sernylan) early in the morning and changes in hormonal levels and energy substrates were determined as the animal awoke. Serum-free fatty acids and plasma cortisol rose during the 4-hr observation period. This was accompanied by a similar rise in urinary catecholamines and 11-hydroxycorticosteroids. An elevation in serum glucose and a decrease in serum insulin were observed but these changes did not achieve statistical significance. Serum growth hormone decreased during the experimental period. These changes are discussed in relation to the use of the awake baboon for experimental shock studies.

Original language	English
Pages (from-to)	24-30
Number of pages	7
Journal	Journal of Surgical Research
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/0022-4804(73)90006-1
State	Published - Jan 1973

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abstract = "Fifteen adult baboons were tranquilized with 1-(1-phenylcyclohexyl) piperidine hydrochloride (Sernylan) early in the morning and changes in hormonal levels and energy substrates were determined as the animal awoke. Serum-free fatty acids and plasma cortisol rose during the 4-hr observation period. This was accompanied by a similar rise in urinary catecholamines and 11-hydroxycorticosteroids. An elevation in serum glucose and a decrease in serum insulin were observed but these changes did not achieve statistical significance. Serum growth hormone decreased during the experimental period. These changes are discussed in relation to the use of the awake baboon for experimental shock studies.",

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AU - Herman, Clifford M.

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The effect of sedation and awakening on energy substrates and hormonal relationships in the subhuman primate

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