The effect of pancreatic islet transplantation and insulin therapy on neuroaxonal dystrophy in sympathetic autonomic ganglia of chronic streptozocin-diabetic rats

Robert E. Schmidt; Santiago B. Plurad; Barbara J. Olack; David W. Scharp

doi:10.1016/0006-8993(89)90287-4

The effect of pancreatic islet transplantation and insulin therapy on neuroaxonal dystrophy in sympathetic autonomic ganglia of chronic streptozocin-diabetic rats

Robert E. Schmidt, Santiago B. Plurad, Barbara J. Olack, David W. Scharp

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The frequency of neuroaxonal dystrophy was determined in the superior mesenteric/celiac sympathetic ganglia in a streptozocin-treated rat model of diabetic autonomic neuropathy. Dystrophic axonopathy was increased 5- to 6-fold in 9-month untreated diabetics compared to age-matched controls. Pancreatic islet transplantation therapy or daily insulin administration prevented the development of dystrophic axonopathy. Transplantation of islets after 6 months of diabetes, a time at which dystrophic axonopathy is well developed, resulted in nearly complete resolution of the neuropathy within 3 months.

Original language	English
Pages (from-to)	393-398
Number of pages	6
Journal	Brain Research
Volume	497
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(89)90287-4
State	Published - Sep 18 1989

Keywords

Diabetes
Pancreatic islet transplantation
Sympathetic neuropathy

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10.1016/0006-8993(89)90287-4

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title = "The effect of pancreatic islet transplantation and insulin therapy on neuroaxonal dystrophy in sympathetic autonomic ganglia of chronic streptozocin-diabetic rats",

abstract = "The frequency of neuroaxonal dystrophy was determined in the superior mesenteric/celiac sympathetic ganglia in a streptozocin-treated rat model of diabetic autonomic neuropathy. Dystrophic axonopathy was increased 5- to 6-fold in 9-month untreated diabetics compared to age-matched controls. Pancreatic islet transplantation therapy or daily insulin administration prevented the development of dystrophic axonopathy. Transplantation of islets after 6 months of diabetes, a time at which dystrophic axonopathy is well developed, resulted in nearly complete resolution of the neuropathy within 3 months.",

keywords = "Diabetes, Pancreatic islet transplantation, Sympathetic neuropathy",

author = "Schmidt, {Robert E.} and Plurad, {Santiago B.} and Olack, {Barbara J.} and Scharp, {David W.}",

note = "Funding Information: We would like to thank Barb Cogswell and Sandy Brickey for their photographic and secretarial assistance, respectively. This work was supported by NIH Grants DK 19645 and 26083, Research Career Development Awards AM 00318 (D.W.S.) and DK 01516 (R.E.S.), Research Grant 81R425 from the Juvenile Diabetes Foundation, and the Kroc Foundation. Streptozocin was a gift of the Upjohn Company.",

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The effect of pancreatic islet transplantation and insulin therapy on neuroaxonal dystrophy in sympathetic autonomic ganglia of chronic streptozocin-diabetic rats. / Schmidt, Robert E.; Plurad, Santiago B.; Olack, Barbara J.; Scharp, David W.

In: Brain Research, Vol. 497, No. 2, 18.09.1989, p. 393-398.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The effect of pancreatic islet transplantation and insulin therapy on neuroaxonal dystrophy in sympathetic autonomic ganglia of chronic streptozocin-diabetic rats

AU - Schmidt, Robert E.

AU - Plurad, Santiago B.

AU - Olack, Barbara J.

AU - Scharp, David W.

N1 - Funding Information: We would like to thank Barb Cogswell and Sandy Brickey for their photographic and secretarial assistance, respectively. This work was supported by NIH Grants DK 19645 and 26083, Research Career Development Awards AM 00318 (D.W.S.) and DK 01516 (R.E.S.), Research Grant 81R425 from the Juvenile Diabetes Foundation, and the Kroc Foundation. Streptozocin was a gift of the Upjohn Company.

PY - 1989/9/18

Y1 - 1989/9/18

N2 - The frequency of neuroaxonal dystrophy was determined in the superior mesenteric/celiac sympathetic ganglia in a streptozocin-treated rat model of diabetic autonomic neuropathy. Dystrophic axonopathy was increased 5- to 6-fold in 9-month untreated diabetics compared to age-matched controls. Pancreatic islet transplantation therapy or daily insulin administration prevented the development of dystrophic axonopathy. Transplantation of islets after 6 months of diabetes, a time at which dystrophic axonopathy is well developed, resulted in nearly complete resolution of the neuropathy within 3 months.

AB - The frequency of neuroaxonal dystrophy was determined in the superior mesenteric/celiac sympathetic ganglia in a streptozocin-treated rat model of diabetic autonomic neuropathy. Dystrophic axonopathy was increased 5- to 6-fold in 9-month untreated diabetics compared to age-matched controls. Pancreatic islet transplantation therapy or daily insulin administration prevented the development of dystrophic axonopathy. Transplantation of islets after 6 months of diabetes, a time at which dystrophic axonopathy is well developed, resulted in nearly complete resolution of the neuropathy within 3 months.

KW - Diabetes

KW - Pancreatic islet transplantation

KW - Sympathetic neuropathy

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The effect of pancreatic islet transplantation and insulin therapy on neuroaxonal dystrophy in sympathetic autonomic ganglia of chronic streptozocin-diabetic rats

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Keywords

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