The effect of pancreatic islet transplantation and insulin therapy on neuroaxonal dystrophy in sympathetic autonomic ganglia of chronic streptozocin-diabetic rats

Robert E. Schmidt, Santiago B. Plurad, Barbara J. Olack, David W. Scharp

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The frequency of neuroaxonal dystrophy was determined in the superior mesenteric/celiac sympathetic ganglia in a streptozocin-treated rat model of diabetic autonomic neuropathy. Dystrophic axonopathy was increased 5- to 6-fold in 9-month untreated diabetics compared to age-matched controls. Pancreatic islet transplantation therapy or daily insulin administration prevented the development of dystrophic axonopathy. Transplantation of islets after 6 months of diabetes, a time at which dystrophic axonopathy is well developed, resulted in nearly complete resolution of the neuropathy within 3 months.

Original languageEnglish
Pages (from-to)393-398
Number of pages6
JournalBrain Research
Volume497
Issue number2
DOIs
StatePublished - Sep 18 1989

Keywords

  • Diabetes
  • Pancreatic islet transplantation
  • Sympathetic neuropathy

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