The effect of nasally administered budesonide respules on adrenal cortex function in patients with chronic rhinosinusitis

Neil S. Sachanandani, Jay F. Piccirillo, Maggie A. Kramper, Stanley E. Thawley, Anna Vlahiotis

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Objectives: To evaluate whether nasal administration of budesonide in adults with chronic rhinosinusitis for 30 days suppresses adrenal function and to assess its clinical efficacy. Design: An open-label prospective study. Setting: Academic medical center. atients: We assessed adrenal function in 9 patients using the cosyntropin test before and after budesonide therapy. Intervention: Budesonide respule therapy. Main Outcome Measure: Scores from the Sino- Nasal Outcome Test-20 (SNOT-20), a tool for assessing rhinosinusitis health and quality of life, were used to assess efficacy of budesonide treatment. Results: All of our patients showed adequate adrenal response to cosyntropin stimulation before and after the budesonide trial. The mean difference in SNOT-20 scores was -1 (95% confidence interval, -1.77 to -0.23; P=.02), indicating clinically significant improvement after therapy. Conclusion: Our findings suggest that using budesonide nasal wash may be clinically effective in decreasing the symptoms of chronic rhinosinusitis and does so without suppression of the hypothalamic-pituitary-adrenal axis in patients with chronic rhinosinusitis.

Original languageEnglish
Pages (from-to)303-307
Number of pages5
JournalArchives of Otolaryngology - Head and Neck Surgery
Volume135
Issue number3
DOIs
StatePublished - Mar 2009

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