The effect of endogenous altered peptide ligands on peripheral T-cell responses

Karine Vidal, Paul M. Allen

Research output: Contribution to journalShort surveypeer-review

8 Scopus citations

Abstract

Numerous studies have shown that a T cell can productively interact through its TCR with less-than-optimal ligands resulting in partial T-cell activation. These ligands, that we called 'altered peptide ligands' (APLs) can act as partial agonists, antagonists or weak agonists for the T cells. Here we discuss the self-antigen system that we used to provide evidence that endogenous APLs exist in vivo and affect T-cell development. We also report the ability of endogenous APLs to induce partial T-cell activation of peripheral T cells, and describe in which circumstances this could occur in vivo.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalSeminars in immunology
Volume8
Issue number2
DOIs
StatePublished - Apr 1996

Keywords

  • Altered peptide ligands
  • Partial T-cell activation
  • Self-antigen
  • T-cell development
  • T-cell receptor antagonists

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