TY - JOUR
T1 - The effect of endogenous altered peptide ligands on peripheral T-cell responses
AU - Vidal, Karine
AU - Allen, Paul M.
PY - 1996/4
Y1 - 1996/4
N2 - Numerous studies have shown that a T cell can productively interact through its TCR with less-than-optimal ligands resulting in partial T-cell activation. These ligands, that we called 'altered peptide ligands' (APLs) can act as partial agonists, antagonists or weak agonists for the T cells. Here we discuss the self-antigen system that we used to provide evidence that endogenous APLs exist in vivo and affect T-cell development. We also report the ability of endogenous APLs to induce partial T-cell activation of peripheral T cells, and describe in which circumstances this could occur in vivo.
AB - Numerous studies have shown that a T cell can productively interact through its TCR with less-than-optimal ligands resulting in partial T-cell activation. These ligands, that we called 'altered peptide ligands' (APLs) can act as partial agonists, antagonists or weak agonists for the T cells. Here we discuss the self-antigen system that we used to provide evidence that endogenous APLs exist in vivo and affect T-cell development. We also report the ability of endogenous APLs to induce partial T-cell activation of peripheral T cells, and describe in which circumstances this could occur in vivo.
KW - Altered peptide ligands
KW - Partial T-cell activation
KW - Self-antigen
KW - T-cell development
KW - T-cell receptor antagonists
UR - http://www.scopus.com/inward/record.url?scp=0029983373&partnerID=8YFLogxK
U2 - 10.1006/smim.1996.0014
DO - 10.1006/smim.1996.0014
M3 - Short survey
C2 - 8920246
AN - SCOPUS:0029983373
VL - 8
SP - 117
EP - 122
JO - Seminars in Immunology
JF - Seminars in Immunology
SN - 1044-5323
IS - 2
ER -