The effect of demineralized bone matrix gel on bone ingrowth and fixation of porous implants

Stephen D. Cook, Samantha L. Salkeld, Laura P. Patron, Robert L. Barrack

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


The presence of demineralized bone matrix (DBM) gel did not enhance or accelerate attachment strength or bone ingrowth and resulted in a significant decrease in implant interface attachment strength at 3 weeks. Hydroxyapatite (HA) coating resulted in significant increases in interface shear strength and bone in-growth compared with non-HA-coated porous implants at all time periods. The HA-coated implants achieved greater attachment strength and bone ingrowth at earlier time periods and maintained greater attachment strength at long-term periods. The results of this study indicate that in the presence of a good bone-implant interference fit, there is no beneficial effect in applying DBM gel to a porous-coated or HA-coated porous implant surface. The small amount that can be applied and the degree of osteoinductivity of DBM seem to preclude it from having a significant biologic effect.

Original languageEnglish
Pages (from-to)402-408
Number of pages7
JournalJournal of Arthroplasty
Issue number4
StatePublished - Jan 1 2002
Externally publishedYes


  • Animal model
  • Bone ingrowth
  • Demineralized bone matrix (DBM)
  • Hydroxyapatite (HA)
  • Implant fixation
  • Porous implants

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