The effect of bile acid synthesis on cholesterol secretion into the bile

S. M. Strasberg, R. G. Ilson

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Cholesterol secretion into the bile has been shown to be related to the bile acid secretion rate. It has been suggested that the availability of bile acid micelles controls the entry of cholesterol into the bile. However, previous data could have been interpreted to indicate that bile acid synthesis controls cholesterol secretion into the bile. To discover whether bile acid synthesis has a significant influence on cholesterol secretion, Rhesus monkeys were studied during the period of increasing bile acid secretion and bile acid synthesis, which begins 6 to 10 hr following interruption of the enterohepatic circulation of bile acids. This is the only condition in which bile acid synthesis and bile acid secretion increase simultaneously. The cholesterol secretion rate fell significantly during this period, and this effect was enhanced by phenobarbital administration. An increasing cholesterol secretion rate would have been expected if micellar attraction controlled cholesterol secretion under these conditions. Bile acid synthesis appears to have an important influence upon cholesterol secretion into the bile.

Original languageEnglish
Pages (from-to)458-465
Number of pages8
JournalAnnals of surgery
Volume181
Issue number4
DOIs
StatePublished - 1975

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