TY - JOUR
T1 - The effect of acute lung injury on the spatial correlation of regional pulmonary blood flow
AU - Schuster, Daniel P.
AU - Markham, Joanne
N1 - Funding Information:
This work was supported in part by NIH grant HL 32815. The authors wish to thank Ms. Lisa
Publisher Copyright:
© 1994 SPIE. All rights reserved.
PY - 1994/5/1
Y1 - 1994/5/1
N2 - We re-analyzed regional pulmonary blood flow (PBF) and lung water concentration (LWC) data obtained by positron emission tomography to calculate the spatial correlation, ρ(d), among picture elements (pixels) as a function of distance, as suggested by Glenny (J Appl Physiol 72:2378, 1992). Animals were studied in the supine position. Data were obtained both at baseline and after oleic acid induced acute lung injury. With this new analytical approach, we confirmed that ρ(d) for PBF is strongly positive for adjacent regions but values fall off steadily, reaching strong negative values, at the greatest distances measured. Acute lung injury affected the relationship between ρ(d) and distance, with less negative correlation at greater distances when perfusion redistribution occurred after injury. However, the magnitude of this effect was not great. The relationship between ρ(d) and distance for LWC was similar to that observed for PBF, but lung injury caused more, not less, negative correlation at greater distances. Since the relationship between ρ(d) and distance does not seem to be very sensitive to changes in perfusion distribution, better descriptors of regional heterogeneity are still needed.
AB - We re-analyzed regional pulmonary blood flow (PBF) and lung water concentration (LWC) data obtained by positron emission tomography to calculate the spatial correlation, ρ(d), among picture elements (pixels) as a function of distance, as suggested by Glenny (J Appl Physiol 72:2378, 1992). Animals were studied in the supine position. Data were obtained both at baseline and after oleic acid induced acute lung injury. With this new analytical approach, we confirmed that ρ(d) for PBF is strongly positive for adjacent regions but values fall off steadily, reaching strong negative values, at the greatest distances measured. Acute lung injury affected the relationship between ρ(d) and distance, with less negative correlation at greater distances when perfusion redistribution occurred after injury. However, the magnitude of this effect was not great. The relationship between ρ(d) and distance for LWC was similar to that observed for PBF, but lung injury caused more, not less, negative correlation at greater distances. Since the relationship between ρ(d) and distance does not seem to be very sensitive to changes in perfusion distribution, better descriptors of regional heterogeneity are still needed.
KW - Oleic acid
KW - Positron emission tomography
KW - Pulmonary edema
UR - http://www.scopus.com/inward/record.url?scp=85076445858&partnerID=8YFLogxK
U2 - 10.1117/12.174411
DO - 10.1117/12.174411
M3 - Conference article
AN - SCOPUS:85076445858
SN - 0277-786X
VL - 2168
SP - 369
EP - 379
JO - Proceedings of SPIE - The International Society for Optical Engineering
JF - Proceedings of SPIE - The International Society for Optical Engineering
T2 - Medical Imaging 1994: Physiology and Function from Multidimensional Images
Y2 - 13 February 1994 through 18 February 1994
ER -