The effect of acute lung injury on the spatial correlation of regional pulmonary blood flow

Daniel P. Schuster, Joanne Markham

Research output: Contribution to journalConference articlepeer-review


We re-analyzed regional pulmonary blood flow (PBF) and lung water concentration (LWC) data obtained by positron emission tomography to calculate the spatial correlation, ρ(d), among picture elements (pixels) as a function of distance, as suggested by Glenny (J Appl Physiol 72:2378, 1992). Animals were studied in the supine position. Data were obtained both at baseline and after oleic acid induced acute lung injury. With this new analytical approach, we confirmed that ρ(d) for PBF is strongly positive for adjacent regions but values fall off steadily, reaching strong negative values, at the greatest distances measured. Acute lung injury affected the relationship between ρ(d) and distance, with less negative correlation at greater distances when perfusion redistribution occurred after injury. However, the magnitude of this effect was not great. The relationship between ρ(d) and distance for LWC was similar to that observed for PBF, but lung injury caused more, not less, negative correlation at greater distances. Since the relationship between ρ(d) and distance does not seem to be very sensitive to changes in perfusion distribution, better descriptors of regional heterogeneity are still needed.

Original languageEnglish
Pages (from-to)369-379
Number of pages11
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - May 1 1994
EventMedical Imaging 1994: Physiology and Function from Multidimensional Images - Newport Beach, United States
Duration: Feb 13 1994Feb 18 1994


  • Oleic acid
  • Positron emission tomography
  • Pulmonary edema


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