The Dynamics of Apoptotic Cell Clearance

Michael R. Elliott, Kodi S. Ravichandran

Research output: Contribution to journalReview articlepeer-review

164 Scopus citations


The phagocytic clearance of dying cells in a tissue is a highly orchestrated series of intercellular events coordinated by a complex signaling network. Recent data from genetic, biochemical, and live-imaging approaches have greatly enhanced our understanding of the dynamics of cell clearance and how the process is orchestrated at the cellular and tissue levels. We discuss how networks regulating apoptotic cell clearance are integrated to enable a rapid, efficient, and high-capacity clearance system within tissues.

Original languageEnglish
Pages (from-to)147-160
Number of pages14
JournalDevelopmental cell
Issue number2
StatePublished - Jul 25 2016


  • apoptosis
  • chemotaxis
  • efferocytosis
  • imaging
  • immunity
  • phagocytosis
  • signal transduction


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