The Dynamics of Apoptotic Cell Clearance

Michael R. Elliott; Kodi S. Ravichandran

doi:10.1016/j.devcel.2016.06.029

The Dynamics of Apoptotic Cell Clearance

Michael R. Elliott, Kodi S. Ravichandran

Research output: Contribution to journal › Review article › peer-review

212 Scopus citations

Abstract

The phagocytic clearance of dying cells in a tissue is a highly orchestrated series of intercellular events coordinated by a complex signaling network. Recent data from genetic, biochemical, and live-imaging approaches have greatly enhanced our understanding of the dynamics of cell clearance and how the process is orchestrated at the cellular and tissue levels. We discuss how networks regulating apoptotic cell clearance are integrated to enable a rapid, efficient, and high-capacity clearance system within tissues.

Original language	English
Pages (from-to)	147-160
Number of pages	14
Journal	Developmental cell
Volume	38
Issue number	2
DOIs	https://doi.org/10.1016/j.devcel.2016.06.029
State	Published - Jul 25 2016

Keywords

apoptosis
chemotaxis
efferocytosis
imaging
immunity
phagocytosis
signal transduction

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10.1016/j.devcel.2016.06.029

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abstract = "The phagocytic clearance of dying cells in a tissue is a highly orchestrated series of intercellular events coordinated by a complex signaling network. Recent data from genetic, biochemical, and live-imaging approaches have greatly enhanced our understanding of the dynamics of cell clearance and how the process is orchestrated at the cellular and tissue levels. We discuss how networks regulating apoptotic cell clearance are integrated to enable a rapid, efficient, and high-capacity clearance system within tissues.",

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AB - The phagocytic clearance of dying cells in a tissue is a highly orchestrated series of intercellular events coordinated by a complex signaling network. Recent data from genetic, biochemical, and live-imaging approaches have greatly enhanced our understanding of the dynamics of cell clearance and how the process is orchestrated at the cellular and tissue levels. We discuss how networks regulating apoptotic cell clearance are integrated to enable a rapid, efficient, and high-capacity clearance system within tissues.

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KW - chemotaxis

KW - efferocytosis

KW - imaging

KW - immunity

KW - phagocytosis

KW - signal transduction

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M3 - Review article

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The Dynamics of Apoptotic Cell Clearance

Abstract

Keywords

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