The Dynamics of Apoptotic Cell Clearance

Michael R. Elliott, Kodi S. Ravichandran

Research output: Contribution to journalReview articlepeer-review

164 Scopus citations

Abstract

The phagocytic clearance of dying cells in a tissue is a highly orchestrated series of intercellular events coordinated by a complex signaling network. Recent data from genetic, biochemical, and live-imaging approaches have greatly enhanced our understanding of the dynamics of cell clearance and how the process is orchestrated at the cellular and tissue levels. We discuss how networks regulating apoptotic cell clearance are integrated to enable a rapid, efficient, and high-capacity clearance system within tissues.

Original languageEnglish
Pages (from-to)147-160
Number of pages14
JournalDevelopmental cell
Volume38
Issue number2
DOIs
StatePublished - Jul 25 2016

Keywords

  • apoptosis
  • chemotaxis
  • efferocytosis
  • imaging
  • immunity
  • phagocytosis
  • signal transduction

Fingerprint

Dive into the research topics of 'The Dynamics of Apoptotic Cell Clearance'. Together they form a unique fingerprint.

Cite this