TY - JOUR
T1 - The dynamic ubiquitin ligase duo
T2 - Cdh1-APC and Cdc20-APC regulate neuronal morphogenesis and connectivity
AU - Yang, Yue
AU - Kim, Albert H.
AU - Bonni, Azad
N1 - Funding Information:
We thank members of the Bonni laboratory for helpful discussions. Supported by NIH grants NS051255 and NS041021 (AB); a NSF fellowship, the Lefler fellowship, and the Ryan foundation (YY); a Ruth L Kirschstein National Research Service Award fellowship, National Cancer Institute, and Brain Science Foundation grant (AHK).
PY - 2010/2
Y1 - 2010/2
N2 - The proper development and patterning of axons, dendrites, and synapses is essential for the establishment of accurate neuronal circuits in the brain. A major goal in neurobiology is to identify the mechanisms and principles that govern these fundamental developmental events of neuronal circuit formation. In recent years, exciting new studies have suggested that ubiquitin signaling pathways may play crucial roles in the control of neuronal connectivity. Among E3 ubiquitin ligases, Cdh1-anaphase promoting complex (Cdh1-APC) and Cdc20-APC have emerged as key regulators of diverse aspects of neuronal connectivity, from axon and dendrite morphogenesis to synapse differentiation and remodeling.
AB - The proper development and patterning of axons, dendrites, and synapses is essential for the establishment of accurate neuronal circuits in the brain. A major goal in neurobiology is to identify the mechanisms and principles that govern these fundamental developmental events of neuronal circuit formation. In recent years, exciting new studies have suggested that ubiquitin signaling pathways may play crucial roles in the control of neuronal connectivity. Among E3 ubiquitin ligases, Cdh1-anaphase promoting complex (Cdh1-APC) and Cdc20-APC have emerged as key regulators of diverse aspects of neuronal connectivity, from axon and dendrite morphogenesis to synapse differentiation and remodeling.
UR - http://www.scopus.com/inward/record.url?scp=76749162906&partnerID=8YFLogxK
U2 - 10.1016/j.conb.2009.12.004
DO - 10.1016/j.conb.2009.12.004
M3 - Review article
C2 - 20060286
AN - SCOPUS:76749162906
SN - 0959-4388
VL - 20
SP - 92
EP - 99
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 1
ER -