TY - JOUR
T1 - The dynamic regulation of NAD metabolism in mitochondria
AU - Stein, Liana Roberts
AU - Imai, Shin Ichiro
N1 - Funding Information:
We apologize to the authors whose work was not directly discussed due to the focus and space limitations of this review. This work was supported, in part, by grants from the National Institute on Aging (AG024150) and the Ellison Medical Foundation to S.I., and by institutional support from the Washington University Nutrition Obesity Research Center (P30DK056341) and the Washington University Diabetes Research and Training Center (P60DK202579). L.R.S. was supported by the training grant (5T32GM007067) from the National Institutes of Health. S.I. serves as a scientific advisory board member for Sirtris, a GlaxoSmithKline company.
PY - 2012/9
Y1 - 2012/9
N2 - Mitochondria are intracellular powerhouses that produce ATP and carry out diverse functions for cellular energy metabolism. Although the maintenance of an optimal NAD/NADH ratio is essential for mitochondrial function, it has recently become apparent that the maintenance of the mitochondrial NAD pool is also of crucial importance. The biosynthesis, transport, and catabolism of NAD and its key intermediates play an important role in the regulation of NAD-consuming mediators, such as sirtuins, poly-ADP-ribose polymerases, and CD38/157 ectoenzymes, in intra- and extracellular compartments. Mitochondrial NAD biosynthesis is also modulated in response to nutritional and environmental stimuli. In this article, we discuss this dynamic regulation of NAD metabolism in mitochondria to shed light on the intimate connection between NAD and mitochondrial function.
AB - Mitochondria are intracellular powerhouses that produce ATP and carry out diverse functions for cellular energy metabolism. Although the maintenance of an optimal NAD/NADH ratio is essential for mitochondrial function, it has recently become apparent that the maintenance of the mitochondrial NAD pool is also of crucial importance. The biosynthesis, transport, and catabolism of NAD and its key intermediates play an important role in the regulation of NAD-consuming mediators, such as sirtuins, poly-ADP-ribose polymerases, and CD38/157 ectoenzymes, in intra- and extracellular compartments. Mitochondrial NAD biosynthesis is also modulated in response to nutritional and environmental stimuli. In this article, we discuss this dynamic regulation of NAD metabolism in mitochondria to shed light on the intimate connection between NAD and mitochondrial function.
UR - http://www.scopus.com/inward/record.url?scp=84865411082&partnerID=8YFLogxK
U2 - 10.1016/j.tem.2012.06.005
DO - 10.1016/j.tem.2012.06.005
M3 - Article
C2 - 22819213
AN - SCOPUS:84865411082
SN - 1043-2760
VL - 23
SP - 420
EP - 428
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 9
ER -