The dynamic regulation of integrin adhesiveness

Michael S. Diamond; Timothy A. Springer

doi:10.1016/S0960-9822(00)00111-1

The dynamic regulation of integrin adhesiveness

Michael S. Diamond, Timothy A. Springer

Research output: Contribution to journal › Article › peer-review

394 Scopus citations

Abstract

The integrins are a family of transmembrane heterodimeric adhesion molecules that play important roles in wound healing, immune system function and organ development. Recent studies indicate that adhesion of integrins to their ligands is not constitutive but is dynamically regulated by intracellular signal transduction pathways.

Original language	English
Pages (from-to)	506-517
Number of pages	12
Journal	Current Biology
Volume	4
Issue number	6
DOIs	https://doi.org/10.1016/S0960-9822(00)00111-1
State	Published - Jun 1994

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10.1016/S0960-9822(00)00111-1

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title = "The dynamic regulation of integrin adhesiveness",

abstract = "The integrins are a family of transmembrane heterodimeric adhesion molecules that play important roles in wound healing, immune system function and organ development. Recent studies indicate that adhesion of integrins to their ligands is not constitutive but is dynamically regulated by intracellular signal transduction pathways.",

author = "Diamond, {Michael S.} and Springer, {Timothy A.}",

note = "Funding Information: We thank Lilli Petruzzelli, Mark Ginsberg, Paul Kassner, and Sam Wright for access to unpublished work, and Lilli Petruzzelli and Mark Ginsberg for their critical comments on the review. This work was supported by grants from the NIH. ",

year = "1994",

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AU - Springer, Timothy A.

N1 - Funding Information: We thank Lilli Petruzzelli, Mark Ginsberg, Paul Kassner, and Sam Wright for access to unpublished work, and Lilli Petruzzelli and Mark Ginsberg for their critical comments on the review. This work was supported by grants from the NIH.

PY - 1994/6

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N2 - The integrins are a family of transmembrane heterodimeric adhesion molecules that play important roles in wound healing, immune system function and organ development. Recent studies indicate that adhesion of integrins to their ligands is not constitutive but is dynamically regulated by intracellular signal transduction pathways.

AB - The integrins are a family of transmembrane heterodimeric adhesion molecules that play important roles in wound healing, immune system function and organ development. Recent studies indicate that adhesion of integrins to their ligands is not constitutive but is dynamically regulated by intracellular signal transduction pathways.

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SN - 0960-9822

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SP - 506

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JO - Current Biology

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The dynamic regulation of integrin adhesiveness

Abstract

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