TY - JOUR
T1 - The dopamine receptor DRD4 gene
T2 - Are duplications distracting?
AU - Todd, Richard D.
AU - O'Malley, Karen L.
PY - 2001/2/1
Y1 - 2001/2/1
N2 - The dopamine D4 receptor DRD4 gene has been implicated in psychotic, mood, addictive, personality, movement and behavioral disorders [e.g. attention deficit hyperactivity disorder (ADHD)]. Now, there is convincing evidence to support the genetic association of DRD4 polymorphisms with ADHD. The particular polymorphism, a 5′ 120-bp duplication, might be functionally active. These findings suggest that manipulation of the DRD4 gene pathway could offer more selective pharmacological approaches to the treatment of ADHD.
AB - The dopamine D4 receptor DRD4 gene has been implicated in psychotic, mood, addictive, personality, movement and behavioral disorders [e.g. attention deficit hyperactivity disorder (ADHD)]. Now, there is convincing evidence to support the genetic association of DRD4 polymorphisms with ADHD. The particular polymorphism, a 5′ 120-bp duplication, might be functionally active. These findings suggest that manipulation of the DRD4 gene pathway could offer more selective pharmacological approaches to the treatment of ADHD.
UR - http://www.scopus.com/inward/record.url?scp=0035252536&partnerID=8YFLogxK
U2 - 10.1016/S0165-6147(00)01612-6
DO - 10.1016/S0165-6147(00)01612-6
M3 - Review article
C2 - 11166839
AN - SCOPUS:0035252536
SN - 0165-6147
VL - 22
SP - 55
EP - 56
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 2
ER -