The dopamine receptor DRD4 gene: Are duplications distracting?

Richard D. Todd, Karen L. O'Malley

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


The dopamine D4 receptor DRD4 gene has been implicated in psychotic, mood, addictive, personality, movement and behavioral disorders [e.g. attention deficit hyperactivity disorder (ADHD)]. Now, there is convincing evidence to support the genetic association of DRD4 polymorphisms with ADHD. The particular polymorphism, a 5′ 120-bp duplication, might be functionally active. These findings suggest that manipulation of the DRD4 gene pathway could offer more selective pharmacological approaches to the treatment of ADHD.

Original languageEnglish
Pages (from-to)55-56
Number of pages2
JournalTrends in Pharmacological Sciences
Issue number2
StatePublished - Feb 1 2001

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