The DNA sequence and analysis of human chromosome 14

Roland Heilig; Ralph Eckenberg; Jean Louis Petit; Núria Fonknechten; Corinne Da Silva; Laurence Cattolico; Michaël Levy; Valérie Barbe; Véronique De Berardinis; Abel Ureta-Vidal; Eric Pelletier; Virginie Vico; Véronique Anthouard; Lee Rowen; Anup Madan; Shizhen Qin; Hui Sun; Hui Du; Kymberlie Pepin; François Artiguenave; Catherine Robert; Corinne Cruaud; Thomas Brüls; Olivier Jalllon; Lucie Friedlander; Gaelle Samson; Philippe Brottier; Susan Cure; Béatrice Ségurens; Franck Anlère; Sylvie Samain; Hervé Crespeau; Nissa Abbasl; Nathalie Aiach; Didler Boscus; Rachel Dickhoff; Monica Dors; Ivan Dubois; Cynthla Friedman; Michel Gouyvenoux; Rose James; Anuradha Madan; Barbara Malrey-Estrada; Sophie Mangenot; Nathalle Martins; Manuela Ménard; Sophie Oztas; Amber Ratcliffe; Tristan Shaffer; Barbara Trask; Benoit Vacherie; Chadla Bellemere; Caroline Belser; Marielle Besnard-Gonnet; Delphine Bartol-Mavel; Magall Boutard; Stéphanie Briez-Silla; Stephane Combette; Virginie Dufossé-Laurent; Carolyne Ferron; Christophe Lechaplais; Claudine Louesse; Delphine Muselet; Ghislaine Magdelenat; Emille Pateau; Emmanuelle Petit; Peggy Sirvain-Trukniewicz; Arnaud Trybou; Nathalle Vega-Czarny; Elodie Bataille; Elodie Bluet; Isabelle Bordelals; Maria Dubois; Corinne Dumont; Thomas Guérin; Sébastien Haffray; Rachid Hammadi; Jacqueline Muanga; Virginie Pellouin; Dominique Robert; Edith Wunderie; Gilbert Gauguet; Alice Roy; Laurent Sainte-Marthe; Jean Verdier; Claude Verdier-Discala; La Deana Hillier; Lucinda Fulton; John McPherson; Fumihiko Matsuda; Rlchard Wilson; Claude Scarpelli; Gábor Gyapay; Patrick Wincker; Willlam Saurin; Francis Quétler; Robert Waterston; Leroy Hood; Jean Weissenbach

doi:10.1038/nature01348

The DNA sequence and analysis of human chromosome 14

Roland Heilig, Ralph Eckenberg, Jean Louis Petit, Núria Fonknechten, Corinne Da Silva, Laurence Cattolico, Michaël Levy, Valérie Barbe, Véronique De Berardinis, Abel Ureta-Vidal, Eric Pelletier, Virginie Vico, Véronique Anthouard, Lee Rowen, Anup Madan, Shizhen Qin, Hui Sun, Hui Du, Kymberlie Pepin, François ArtiguenaveCatherine Robert, Corinne Cruaud, Thomas Brüls, Olivier Jalllon, Lucie Friedlander, Gaelle Samson, Philippe Brottier, Susan Cure, Béatrice Ségurens, Franck Anlère, Sylvie Samain, Hervé Crespeau, Nissa Abbasl, Nathalie Aiach, Didler Boscus, Rachel Dickhoff, Monica Dors, Ivan Dubois, Cynthla Friedman, Michel Gouyvenoux, Rose James, Anuradha Madan, Barbara Malrey-Estrada, Sophie Mangenot, Nathalle Martins, Manuela Ménard, Sophie Oztas, Amber Ratcliffe, Tristan Shaffer, Barbara Trask, Benoit Vacherie, Chadla Bellemere, Caroline Belser, Marielle Besnard-Gonnet, Delphine Bartol-Mavel, Magall Boutard, Stéphanie Briez-Silla, Stephane Combette, Virginie Dufossé-Laurent, Carolyne Ferron, Christophe Lechaplais, Claudine Louesse, Delphine Muselet, Ghislaine Magdelenat, Emille Pateau, Emmanuelle Petit, Peggy Sirvain-Trukniewicz, Arnaud Trybou, Nathalle Vega-Czarny, Elodie Bataille, Elodie Bluet, Isabelle Bordelals, Maria Dubois, Corinne Dumont, Thomas Guérin, Sébastien Haffray, Rachid Hammadi, Jacqueline Muanga, Virginie Pellouin, Dominique Robert, Edith Wunderie, Gilbert Gauguet, Alice Roy, Laurent Sainte-Marthe, Jean Verdier, Claude Verdier-Discala, La Deana Hillier, Lucinda Fulton, John McPherson, Fumihiko Matsuda, Rlchard Wilson, Claude Scarpelli, Gábor Gyapay, Patrick Wincker, Willlam Saurin, Francis Quétler, Robert Waterston, Leroy Hood, Jean Weissenbach

McDonnell Genome Institute (MGI)

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

Chromosome 14 is one of five acrocentric chromosomes in the human genome. These chromosomes are characterized by a heterochromatic short arm that contains essentially ribosomal RNA genes, and a euchromatic long arm in which most, if not all, of the protein-coding genes are located. The finished sequence of human chromosome 14 comprises 87,410,661 base pairs, representing 100% of its euchromatic portion, in a single continuous segment covering the entire long arm with no gaps. Two loci of crucial importance for the immune system, as well as more than 60 disease genes, have been localized so far on chromosome 14. We identified 1,050 genes and gene fragments, and 393 pseudogenes. On the basis of comparisons with other vertebrate genomes, we estimate that more than 96% of the chromosome 14 genes have been annotated. From an analysis of the CpG island occurrences, we estimate that 70% of these annotated genes are complete at their 5′ end.

Original language	English
Pages (from-to)	601-607
Number of pages	7
Journal	Nature
Volume	421
Issue number	6923
DOIs	https://doi.org/10.1038/nature01348
State	Published - Feb 6 2003

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Heilig, R., Eckenberg, R., Petit, J. L., Fonknechten, N., Da Silva, C., Cattolico, L., Levy, M., Barbe, V., De Berardinis, V., Ureta-Vidal, A., Pelletier, E., Vico, V., Anthouard, V., Rowen, L., Madan, A., Qin, S., Sun, H., Du, H., Pepin, K., ... Weissenbach, J. (2003). The DNA sequence and analysis of human chromosome 14. Nature, 421(6923), 601-607. https://doi.org/10.1038/nature01348

@article{83441ca8e0f54435a635e6787bc9d598,

title = "The DNA sequence and analysis of human chromosome 14",

abstract = "Chromosome 14 is one of five acrocentric chromosomes in the human genome. These chromosomes are characterized by a heterochromatic short arm that contains essentially ribosomal RNA genes, and a euchromatic long arm in which most, if not all, of the protein-coding genes are located. The finished sequence of human chromosome 14 comprises 87,410,661 base pairs, representing 100% of its euchromatic portion, in a single continuous segment covering the entire long arm with no gaps. Two loci of crucial importance for the immune system, as well as more than 60 disease genes, have been localized so far on chromosome 14. We identified 1,050 genes and gene fragments, and 393 pseudogenes. On the basis of comparisons with other vertebrate genomes, we estimate that more than 96% of the chromosome 14 genes have been annotated. From an analysis of the CpG island occurrences, we estimate that 70% of these annotated genes are complete at their 5′ end.",

author = "Roland Heilig and Ralph Eckenberg and Petit, {Jean Louis} and N{\'u}ria Fonknechten and {Da Silva}, Corinne and Laurence Cattolico and Micha{\"e}l Levy and Val{\'e}rie Barbe and {De Berardinis}, V{\'e}ronique and Abel Ureta-Vidal and Eric Pelletier and Virginie Vico and V{\'e}ronique Anthouard and Lee Rowen and Anup Madan and Shizhen Qin and Hui Sun and Hui Du and Kymberlie Pepin and Fran{\c c}ois Artiguenave and Catherine Robert and Corinne Cruaud and Thomas Br{\"u}ls and Olivier Jalllon and Lucie Friedlander and Gaelle Samson and Philippe Brottier and Susan Cure and B{\'e}atrice S{\'e}gurens and Franck Anl{\`e}re and Sylvie Samain and Herv{\'e} Crespeau and Nissa Abbasl and Nathalie Aiach and Didler Boscus and Rachel Dickhoff and Monica Dors and Ivan Dubois and Cynthla Friedman and Michel Gouyvenoux and Rose James and Anuradha Madan and Barbara Malrey-Estrada and Sophie Mangenot and Nathalle Martins and Manuela M{\'e}nard and Sophie Oztas and Amber Ratcliffe and Tristan Shaffer and Barbara Trask and Benoit Vacherie and Chadla Bellemere and Caroline Belser and Marielle Besnard-Gonnet and Delphine Bartol-Mavel and Magall Boutard and St{\'e}phanie Briez-Silla and Stephane Combette and Virginie Dufoss{\'e}-Laurent and Carolyne Ferron and Christophe Lechaplais and Claudine Louesse and Delphine Muselet and Ghislaine Magdelenat and Emille Pateau and Emmanuelle Petit and Peggy Sirvain-Trukniewicz and Arnaud Trybou and Nathalle Vega-Czarny and Elodie Bataille and Elodie Bluet and Isabelle Bordelals and Maria Dubois and Corinne Dumont and Thomas Gu{\'e}rin and S{\'e}bastien Haffray and Rachid Hammadi and Jacqueline Muanga and Virginie Pellouin and Dominique Robert and Edith Wunderie and Gilbert Gauguet and Alice Roy and Laurent Sainte-Marthe and Jean Verdier and Claude Verdier-Discala and Hillier, {La Deana} and Lucinda Fulton and John McPherson and Fumihiko Matsuda and Rlchard Wilson and Claude Scarpelli and G{\'a}bor Gyapay and Patrick Wincker and Willlam Saurin and Francis Qu{\'e}tler and Robert Waterston and Leroy Hood and Jean Weissenbach",

year = "2003",

month = feb,

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doi = "10.1038/nature01348",

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Heilig, R, Eckenberg, R, Petit, JL, Fonknechten, N, Da Silva, C, Cattolico, L, Levy, M, Barbe, V, De Berardinis, V, Ureta-Vidal, A, Pelletier, E, Vico, V, Anthouard, V, Rowen, L, Madan, A, Qin, S, Sun, H, Du, H, Pepin, K, Artiguenave, F, Robert, C, Cruaud, C, Brüls, T, Jalllon, O, Friedlander, L, Samson, G, Brottier, P, Cure, S, Ségurens, B, Anlère, F, Samain, S, Crespeau, H, Abbasl, N, Aiach, N, Boscus, D, Dickhoff, R, Dors, M, Dubois, I, Friedman, C, Gouyvenoux, M, James, R, Madan, A, Malrey-Estrada, B, Mangenot, S, Martins, N, Ménard, M, Oztas, S, Ratcliffe, A, Shaffer, T, Trask, B, Vacherie, B, Bellemere, C, Belser, C, Besnard-Gonnet, M, Bartol-Mavel, D, Boutard, M, Briez-Silla, S, Combette, S, Dufossé-Laurent, V, Ferron, C, Lechaplais, C, Louesse, C, Muselet, D, Magdelenat, G, Pateau, E, Petit, E, Sirvain-Trukniewicz, P, Trybou, A, Vega-Czarny, N, Bataille, E, Bluet, E, Bordelals, I, Dubois, M, Dumont, C, Guérin, T, Haffray, S, Hammadi, R, Muanga, J, Pellouin, V, Robert, D, Wunderie, E, Gauguet, G, Roy, A, Sainte-Marthe, L, Verdier, J, Verdier-Discala, C, Hillier, LD, Fulton, L, McPherson, J, Matsuda, F, Wilson, R, Scarpelli, C, Gyapay, G, Wincker, P, Saurin, W, Quétler, F, Waterston, R, Hood, L & Weissenbach, J 2003, 'The DNA sequence and analysis of human chromosome 14', Nature, vol. 421, no. 6923, pp. 601-607. https://doi.org/10.1038/nature01348

TY - JOUR

T1 - The DNA sequence and analysis of human chromosome 14

AU - Heilig, Roland

AU - Eckenberg, Ralph

AU - Petit, Jean Louis

AU - Fonknechten, Núria

AU - Da Silva, Corinne

AU - Cattolico, Laurence

AU - Levy, Michaël

AU - Barbe, Valérie

AU - De Berardinis, Véronique

AU - Ureta-Vidal, Abel

AU - Pelletier, Eric

AU - Vico, Virginie

AU - Anthouard, Véronique

AU - Rowen, Lee

AU - Madan, Anup

AU - Qin, Shizhen

AU - Sun, Hui

AU - Du, Hui

AU - Pepin, Kymberlie

AU - Artiguenave, François

AU - Robert, Catherine

AU - Cruaud, Corinne

AU - Brüls, Thomas

AU - Jalllon, Olivier

AU - Friedlander, Lucie

AU - Samson, Gaelle

AU - Brottier, Philippe

AU - Cure, Susan

AU - Ségurens, Béatrice

AU - Anlère, Franck

AU - Samain, Sylvie

AU - Crespeau, Hervé

AU - Abbasl, Nissa

AU - Aiach, Nathalie

AU - Boscus, Didler

AU - Dickhoff, Rachel

AU - Dors, Monica

AU - Dubois, Ivan

AU - Friedman, Cynthla

AU - Gouyvenoux, Michel

AU - James, Rose

AU - Madan, Anuradha

AU - Malrey-Estrada, Barbara

AU - Mangenot, Sophie

AU - Martins, Nathalle

AU - Ménard, Manuela

AU - Oztas, Sophie

AU - Ratcliffe, Amber

AU - Shaffer, Tristan

AU - Trask, Barbara

AU - Vacherie, Benoit

AU - Bellemere, Chadla

AU - Belser, Caroline

AU - Besnard-Gonnet, Marielle

AU - Bartol-Mavel, Delphine

AU - Boutard, Magall

AU - Briez-Silla, Stéphanie

AU - Combette, Stephane

AU - Dufossé-Laurent, Virginie

AU - Ferron, Carolyne

AU - Lechaplais, Christophe

AU - Louesse, Claudine

AU - Muselet, Delphine

AU - Magdelenat, Ghislaine

AU - Pateau, Emille

AU - Petit, Emmanuelle

AU - Sirvain-Trukniewicz, Peggy

AU - Trybou, Arnaud

AU - Vega-Czarny, Nathalle

AU - Bataille, Elodie

AU - Bluet, Elodie

AU - Bordelals, Isabelle

AU - Dubois, Maria

AU - Dumont, Corinne

AU - Guérin, Thomas

AU - Haffray, Sébastien

AU - Hammadi, Rachid

AU - Muanga, Jacqueline

AU - Pellouin, Virginie

AU - Robert, Dominique

AU - Wunderie, Edith

AU - Gauguet, Gilbert

AU - Roy, Alice

AU - Sainte-Marthe, Laurent

AU - Verdier, Jean

AU - Verdier-Discala, Claude

AU - Hillier, La Deana

AU - Fulton, Lucinda

AU - McPherson, John

AU - Matsuda, Fumihiko

AU - Wilson, Rlchard

AU - Scarpelli, Claude

AU - Gyapay, Gábor

AU - Wincker, Patrick

AU - Saurin, Willlam

AU - Quétler, Francis

AU - Waterston, Robert

AU - Hood, Leroy

AU - Weissenbach, Jean

PY - 2003/2/6

Y1 - 2003/2/6

N2 - Chromosome 14 is one of five acrocentric chromosomes in the human genome. These chromosomes are characterized by a heterochromatic short arm that contains essentially ribosomal RNA genes, and a euchromatic long arm in which most, if not all, of the protein-coding genes are located. The finished sequence of human chromosome 14 comprises 87,410,661 base pairs, representing 100% of its euchromatic portion, in a single continuous segment covering the entire long arm with no gaps. Two loci of crucial importance for the immune system, as well as more than 60 disease genes, have been localized so far on chromosome 14. We identified 1,050 genes and gene fragments, and 393 pseudogenes. On the basis of comparisons with other vertebrate genomes, we estimate that more than 96% of the chromosome 14 genes have been annotated. From an analysis of the CpG island occurrences, we estimate that 70% of these annotated genes are complete at their 5′ end.

AB - Chromosome 14 is one of five acrocentric chromosomes in the human genome. These chromosomes are characterized by a heterochromatic short arm that contains essentially ribosomal RNA genes, and a euchromatic long arm in which most, if not all, of the protein-coding genes are located. The finished sequence of human chromosome 14 comprises 87,410,661 base pairs, representing 100% of its euchromatic portion, in a single continuous segment covering the entire long arm with no gaps. Two loci of crucial importance for the immune system, as well as more than 60 disease genes, have been localized so far on chromosome 14. We identified 1,050 genes and gene fragments, and 393 pseudogenes. On the basis of comparisons with other vertebrate genomes, we estimate that more than 96% of the chromosome 14 genes have been annotated. From an analysis of the CpG island occurrences, we estimate that 70% of these annotated genes are complete at their 5′ end.

UR - http://www.scopus.com/inward/record.url?scp=0037421899&partnerID=8YFLogxK

U2 - 10.1038/nature01348

DO - 10.1038/nature01348

M3 - Article

C2 - 12508121

AN - SCOPUS:0037421899

SN - 0028-0836

VL - 421

SP - 601

EP - 607

JO - Nature

JF - Nature

IS - 6923

ER -

The DNA sequence and analysis of human chromosome 14

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