The disruption of immunoglobulin caps by local anesthetics

George F. Schreiner; Emil R. Unanue

doi:10.1016/0090-1229(76)90118-5

The disruption of immunoglobulin caps by local anesthetics

George F. Schreiner
, Emil R. Unanue

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Surface complexes of Ig-anti-Ig (Ig, immunoglobulin) readily redistribute into caps. Local anesthetics (lidocaine and chlorpromazine) disrupt the caps, the complexes disseminating over the entire surface. Removal of the anesthetic then allows the complexes to reform into caps. The effects of the anesthetics on cap disruption were counteracted by an increase in extracellular Ca²⁺ and were not energy dependent. The inhibition of cap formation by anesthetic is also counteracted by increased extracellular Ca²⁺.

Original language	English
Pages (from-to)	264-269
Number of pages	6
Journal	Clinical Immunology and Immunopathology
Volume	6
Issue number	2
DOIs	https://doi.org/10.1016/0090-1229(76)90118-5
State	Published - Sep 1976

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title = "The disruption of immunoglobulin caps by local anesthetics",

abstract = "Surface complexes of Ig-anti-Ig (Ig, immunoglobulin) readily redistribute into caps. Local anesthetics (lidocaine and chlorpromazine) disrupt the caps, the complexes disseminating over the entire surface. Removal of the anesthetic then allows the complexes to reform into caps. The effects of the anesthetics on cap disruption were counteracted by an increase in extracellular Ca2+ and were not energy dependent. The inhibition of cap formation by anesthetic is also counteracted by increased extracellular Ca2+.",

author = "Schreiner, \{George F.\} and Unanue, \{Emil R.\}",

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AU - Schreiner, George F.

AU - Unanue, Emil R.

PY - 1976/9

Y1 - 1976/9

N2 - Surface complexes of Ig-anti-Ig (Ig, immunoglobulin) readily redistribute into caps. Local anesthetics (lidocaine and chlorpromazine) disrupt the caps, the complexes disseminating over the entire surface. Removal of the anesthetic then allows the complexes to reform into caps. The effects of the anesthetics on cap disruption were counteracted by an increase in extracellular Ca2+ and were not energy dependent. The inhibition of cap formation by anesthetic is also counteracted by increased extracellular Ca2+.

AB - Surface complexes of Ig-anti-Ig (Ig, immunoglobulin) readily redistribute into caps. Local anesthetics (lidocaine and chlorpromazine) disrupt the caps, the complexes disseminating over the entire surface. Removal of the anesthetic then allows the complexes to reform into caps. The effects of the anesthetics on cap disruption were counteracted by an increase in extracellular Ca2+ and were not energy dependent. The inhibition of cap formation by anesthetic is also counteracted by increased extracellular Ca2+.

UR - https://www.scopus.com/pages/publications/0017136796

U2 - 10.1016/0090-1229(76)90118-5

DO - 10.1016/0090-1229(76)90118-5

M3 - Article

C2 - 1085687

AN - SCOPUS:0017136796

SN - 0090-1229

VL - 6

SP - 264

EP - 269

JO - Clinical Immunology and Immunopathology

JF - Clinical Immunology and Immunopathology

IS - 2

ER -

The disruption of immunoglobulin caps by local anesthetics

Abstract

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