The disruption of immunoglobulin caps by local anesthetics

George F. Schreiner, Emil R. Unanue

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Surface complexes of Ig-anti-Ig (Ig, immunoglobulin) readily redistribute into caps. Local anesthetics (lidocaine and chlorpromazine) disrupt the caps, the complexes disseminating over the entire surface. Removal of the anesthetic then allows the complexes to reform into caps. The effects of the anesthetics on cap disruption were counteracted by an increase in extracellular Ca2+ and were not energy dependent. The inhibition of cap formation by anesthetic is also counteracted by increased extracellular Ca2+.

Original languageEnglish
Pages (from-to)264-269
Number of pages6
JournalClinical Immunology and Immunopathology
Volume6
Issue number2
DOIs
StatePublished - Sep 1976

Fingerprint

Dive into the research topics of 'The disruption of immunoglobulin caps by local anesthetics'. Together they form a unique fingerprint.

Cite this