TY - JOUR
T1 - The disruption of immunoglobulin caps by local anesthetics
AU - Schreiner, George F.
AU - Unanue, Emil R.
PY - 1976/9
Y1 - 1976/9
N2 - Surface complexes of Ig-anti-Ig (Ig, immunoglobulin) readily redistribute into caps. Local anesthetics (lidocaine and chlorpromazine) disrupt the caps, the complexes disseminating over the entire surface. Removal of the anesthetic then allows the complexes to reform into caps. The effects of the anesthetics on cap disruption were counteracted by an increase in extracellular Ca2+ and were not energy dependent. The inhibition of cap formation by anesthetic is also counteracted by increased extracellular Ca2+.
AB - Surface complexes of Ig-anti-Ig (Ig, immunoglobulin) readily redistribute into caps. Local anesthetics (lidocaine and chlorpromazine) disrupt the caps, the complexes disseminating over the entire surface. Removal of the anesthetic then allows the complexes to reform into caps. The effects of the anesthetics on cap disruption were counteracted by an increase in extracellular Ca2+ and were not energy dependent. The inhibition of cap formation by anesthetic is also counteracted by increased extracellular Ca2+.
UR - http://www.scopus.com/inward/record.url?scp=0017136796&partnerID=8YFLogxK
U2 - 10.1016/0090-1229(76)90118-5
DO - 10.1016/0090-1229(76)90118-5
M3 - Article
C2 - 1085687
AN - SCOPUS:0017136796
SN - 0090-1229
VL - 6
SP - 264
EP - 269
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 2
ER -