TY - JOUR
T1 - The development of sustained and transient neural activity
AU - Burgund, E. Darcy
AU - Lugar, Heather M.
AU - Miezin, Francis M.
AU - Schlaggar, Bradley L.
AU - Petersen, Steven E.
N1 - Funding Information:
The authors would like to thank Abraham Snyder for invaluable technical assistance. B.L.S. is a scholar of the Child Health Research Center of Excellence in Developmental Biology at Washington University School of Medicine (HD01487). Other support for this research was provided by the McDonnell Center for Higher Brain Function (BLS), by the National Institute of Health, NS32979 (SEP), NS51733 (SEP), NS55582 (BLS), and LM06858 (SEP), and by the Social Sciences Division at Rice University (EDB).
PY - 2006/2/1
Y1 - 2006/2/1
N2 - Sustained and transient signals were compared in a group of 7-8-year-old children and a group of adults performing the same cognitive task using functional magnetic resonance imaging (fMRI) in conjunction with a mixed blocked/event-related design. Results revealed several regions, including a region in the right lateral inferior frontal gyrus, that exhibited opposing developmental trajectories in sustained and transient signals-in particular, decreased sustained signals and increased transient signals with age. Re-analysis of the data assuming "blocked" and "event- related" designs, as opposed to a mixed design, produced different results. In combination, these results may help to explain contradictory findings in the literature regarding the direction of neural development in frontal cortex. Moreover, these results underscore the value of separating sustained and transient signals in fMRI studies of development.
AB - Sustained and transient signals were compared in a group of 7-8-year-old children and a group of adults performing the same cognitive task using functional magnetic resonance imaging (fMRI) in conjunction with a mixed blocked/event-related design. Results revealed several regions, including a region in the right lateral inferior frontal gyrus, that exhibited opposing developmental trajectories in sustained and transient signals-in particular, decreased sustained signals and increased transient signals with age. Re-analysis of the data assuming "blocked" and "event- related" designs, as opposed to a mixed design, produced different results. In combination, these results may help to explain contradictory findings in the literature regarding the direction of neural development in frontal cortex. Moreover, these results underscore the value of separating sustained and transient signals in fMRI studies of development.
UR - http://www.scopus.com/inward/record.url?scp=31044441055&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2005.08.056
DO - 10.1016/j.neuroimage.2005.08.056
M3 - Article
C2 - 16236529
AN - SCOPUS:31044441055
SN - 1053-8119
VL - 29
SP - 812
EP - 821
JO - NeuroImage
JF - NeuroImage
IS - 3
ER -