TY - JOUR
T1 - The development of normal and ectopic sensilla in the wings of hairy and hairy wing mutants of Drosophila
AU - Blair, Seth S.
AU - Giangrande, Angela
AU - Skeath, James B.
AU - Palka, John
N1 - Funding Information:
We thank Drs. M. Schubiger and M. Murray for suggestions on the manuscript and Drs. S. Carroll and J. Modolell for discussions and communication of results prior to publication. Thanks also to Bill Feeny for assistance with Figs. 1 and 4. This work was supported by NSF Research Grant BNS-9096100 and NINDS Research Grant R01-NS28202 (SSB), a Postdoctoral Fellowship from EMBO (A.G.), an NIH Predoctoral Fellowship and a Howard Hughes Medical Institute Investigatorship to Sean Carroll (J.B.S.), and NSF Research Grant BNS-9011028 and NINDS Research Grant R01-NS07778 (J.P.).
PY - 1992/7
Y1 - 1992/7
N2 - We have utilized enhancer trap markers to follow the development of ectopic sensillar precursors in the wings of Drosophila induced by the mutations hairy and Hairy wing. Normal sensilla are still present in these mutations, and can be distinguished from ectopic sensilla based upon both the position and the timing of their development. This correlates well with the development of ectopic achaete expression in these mutations: such staining is detected only after the appearance of normal staining. Thus, neither mutation appears to alter the specification of proneural clusters in the wing, as identified with anti-achaete, or the specification of sensillar precursors within these clusters. Rather, both act to induce the formation of a temporally and spatially distinct phase of sensillar development.
AB - We have utilized enhancer trap markers to follow the development of ectopic sensillar precursors in the wings of Drosophila induced by the mutations hairy and Hairy wing. Normal sensilla are still present in these mutations, and can be distinguished from ectopic sensilla based upon both the position and the timing of their development. This correlates well with the development of ectopic achaete expression in these mutations: such staining is detected only after the appearance of normal staining. Thus, neither mutation appears to alter the specification of proneural clusters in the wing, as identified with anti-achaete, or the specification of sensillar precursors within these clusters. Rather, both act to induce the formation of a temporally and spatially distinct phase of sensillar development.
KW - Achaete-scute complex
KW - Helix-loop-helix protein
KW - Imaginal disc
KW - Neurogenesis
UR - http://www.scopus.com/inward/record.url?scp=0026645827&partnerID=8YFLogxK
U2 - 10.1016/0925-4773(92)90033-G
DO - 10.1016/0925-4773(92)90033-G
M3 - Article
C2 - 1381943
AN - SCOPUS:0026645827
SN - 0925-4773
VL - 38
SP - 3
EP - 16
JO - Mechanisms of Development
JF - Mechanisms of Development
IS - 1
ER -