The development of non-coding RNA ontology

Jingshan Huang, Karen Eilbeck, Barry Smith, Judith A. Blake, Dejing Dou, Weili Huang, Darren A. Natale, Alan Ruttenberg, Jun Huan, Michael T. Zimmermann, Guoqian Jiang, Yu Lin, Bin Wu, Harrison J. Strachan, Nisansa De Silva, Mohan Vamsi Kasukurthi, Vikash Kumar Jha, Yongqun He, Shaojie Zhang, Xiaowei WangZixing Liu, Glen M. Borchert, Ming Tan

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Identification of non-coding RNAs (ncRNAs) has been significantly improved over the past decade. On the other hand, semantic annotation of ncRNA data is facing critical challenges due to the lack of a comprehensive ontology to serve as common data elements and data exchange standards in the field. We developed the Non-Coding RNA Ontology (NCRO) to handle this situation. By providing a formally defined ncRNA controlled vocabulary, the NCRO aims to fill a specific and highly needed niche in semantic annotation of large amounts of ncRNA biological and clinical data.

Original languageEnglish
Pages (from-to)214-232
Number of pages19
JournalInternational Journal of Data Mining and Bioinformatics
Volume15
Issue number3
DOIs
StatePublished - 2016

Keywords

  • Bio-ontologies
  • Domain ontology
  • Non-coding RNA
  • Ontology development
  • Reference ontology
  • Semantic data annotation

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