The cysteine regulatory complex from plants and microbes: What was old is new again

Joseph M. Jez, Sanghamitra Dey

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations

Abstract

The physical organization of enzymes in metabolism is an old concept being revisited by new experimental approaches. In plants and microbes, the enzymes of cysteine biosynthesis serine acetyltransferase (SAT) and O-acetylserine sulfhydrylase (OASS) form a bi-enzyme complex called the cysteine regulatory complex (CRC), which likely plays a role in modulating cysteine biosynthesis in response to sulfur nutrient state. Structural and biochemical studies of SAT and OASS as individual enzymes and recent advances in structural, biophysical, and in vivo analysis of the CRC provide new insights on the function of this macromolecular assembly in plants and microbes and opens biotechnology and pharmaceutical opportunities for future exploration.

Original languageEnglish
Pages (from-to)302-310
Number of pages9
JournalCurrent Opinion in Structural Biology
Volume23
Issue number2
DOIs
StatePublished - Apr 2013

Fingerprint

Dive into the research topics of 'The cysteine regulatory complex from plants and microbes: What was old is new again'. Together they form a unique fingerprint.

Cite this