TY - JOUR
T1 - The Current status of coagulation
AU - Luchtman-Jones, Lori
AU - Broze, George J.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - In 1964, the events of haemostasis were organized into the intrinsic and extrinsic pathways by the cascade/waterfall hypothesis, with primary physiological importance being given to the intrinsic pathway. Recent experimental evidence, as well as information about the clinical course of patients with various coagulation factor deficiencies, indicates a more prominent role for tissue factor. Rediscovery of the plasma protease inhibitor, tissue factor pathway inhibitor, and new information about the activation of factor XI have supported a revised theory of coagulation.
AB - In 1964, the events of haemostasis were organized into the intrinsic and extrinsic pathways by the cascade/waterfall hypothesis, with primary physiological importance being given to the intrinsic pathway. Recent experimental evidence, as well as information about the clinical course of patients with various coagulation factor deficiencies, indicates a more prominent role for tissue factor. Rediscovery of the plasma protease inhibitor, tissue factor pathway inhibitor, and new information about the activation of factor XI have supported a revised theory of coagulation.
KW - Haemostasis
KW - Tissue factor pathway inhibitor
UR - http://www.scopus.com/inward/record.url?scp=0028908012&partnerID=8YFLogxK
U2 - 10.3109/07853899509031935
DO - 10.3109/07853899509031935
M3 - Article
C2 - 7741998
AN - SCOPUS:0028908012
SN - 0785-3890
VL - 27
SP - 47
EP - 52
JO - Annals of Medicine
JF - Annals of Medicine
IS - 1
ER -