The Cox-maze IV procedure for lone atrial fibrillation: A single center experience in 100 consecutive patients

Timo Weimar, Marci S. Bailey, Yoshiyuki Watanabe, Donna Marin, Hersh S. Maniar, Richard B. Schuessler, Ralph J. Damiano

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


Purpose: The Cox-maze III procedure (CMP) has achieved high success rates for the surgical treatment of atrial fibrillation (AF). In 2002, our group introduced a simplified CMP, in which most incisions were replaced with linear lines of ablation using bipolar radiofrequency and cryoenergy. This operation, termed the CMP-IV, has significantly shortened operative times and allowed for a minimally invasive approach. This report evaluates our results in 100 consecutive patients undergoing a stand-alone CMP-IV. Methods: Data were collected prospectively on 100 patients (mean age, 56 ± 10 years) who underwent a CMP-IV from January 2002 through May 2010. All patients were available for follow-up with a mean follow-up of 17 ± 10 months. Electrocardiograms or 24-h Holter monitorings were obtained at 6, 12, and 24 months. Data were analyzed using a longitudinal database containing over 380 variables. Results: Thirty-one percent of patients had paroxysmal AF, with the remainder having persistent (6%) or longstanding persistent AF (63%). The mean preoperative duration of AF was 7.4 ± 6.7 years. The mean left atrial diameter was 4.7 ± 1.1 cm. In this group, 40 patients had failed with a mean of 2.6 ± 1.3 catheter ablations. Mean aortic cross-clamp time was 41 ± 13 min. There was one postoperative mortality. Postoperative freedom from AF was 93%, 90%, and 90% at 6, 12, and 24 months, respectively. Freedom from AF off antiarrhythmic medication was 82%, 82%, and 84% at 6, 12, and 24 months, respectively. Conclusion: The less invasive CMP-IV has a high single procedure success rate, even with improved follow-up and stricter definitions of failure.

Original languageEnglish
Pages (from-to)47-54
Number of pages8
JournalJournal of Interventional Cardiac Electrophysiology
Issue number1
StatePublished - Jun 2011


  • Ablation
  • Arrhythmia
  • Atrial fibrillation
  • Cox-maze procedure
  • Surgery

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