The costimulatory function of antigen-presenting cells

C. T. Weaver, E. R. Unanue

Research output: Contribution to journalReview articlepeer-review

285 Scopus citations

Abstract

In addition to the expression of MHC-antigen complexes and molecules which non-specifically promote cell adhesion, antigen-presenting cells (APCs) provide costimulatory activity for T-lymphocyte stimulation. Costimulatory molecules are essential for activation and multiplication: the presentation of antigen by cells lacking such molecules may lead to T-cell tolerance. In this review, Casey Weaver and Emil Unanue update information on interleukin 1 (IL-1), the original and best-studied costimulator, and investigate the nature of novel, as yet uncharacterized, costimulatory molecules.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalImmunology today
Volume11
Issue number2
StatePublished - 1990

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