Abstract
In addition to the expression of MHC-antigen complexes and molecules which non-specifically promote cell adhesion, antigen-presenting cells (APCs) provide costimulatory activity for T-lymphocyte stimulation. Costimulatory molecules are essential for activation and multiplication: the presentation of antigen by cells lacking such molecules may lead to T-cell tolerance. In this review, Casey Weaver and Emil Unanue update information on interleukin 1 (IL-1), the original and best-studied costimulator, and investigate the nature of novel, as yet uncharacterized, costimulatory molecules.
| Original language | English |
|---|---|
| Pages (from-to) | 49-55 |
| Number of pages | 7 |
| Journal | Immunology today |
| Volume | 11 |
| Issue number | 2 |
| State | Published - 1990 |