Abstract

In addition to the expression of MHC - antigen complexes and molecules which non-spedfically promote cell adhesion, antigen-presenting cells (APCs) provide costimulatory activity for T-lymphocyte stimulation. Costimulatory molecules are essential for activation and multiplication: the presentation of antigen by cells lacking such molecules may lead to T-cell tolerance. In this review, Casey Weaver and Emil Unanue update information on interleukin 1 (IL-1), the original and best-studied commutator, and investigate the nature of novel, as yet uncharacterized, costimulatory molecules.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalImmunology today
Volume11
StatePublished - 1990

Fingerprint

Dive into the research topics of 'The costimulatory function of antigen-presenting cells'. Together they form a unique fingerprint.

Cite this