TY - JOUR
T1 - The Correlation between Vitamin D Levels and the Risk of Postoperative Recurrence in Crohn's Disease
AU - Yamada, Akihiro
AU - Komaki, Yuga
AU - Komaki, Fukiko
AU - Haider, Haider
AU - Micic, Dejan
AU - Pekow, Joel
AU - Dalal, Sushila
AU - Cohen, Russell D.
AU - Cannon, Lisa
AU - Umanskiy, Konstantin
AU - Smith, Radhika
AU - Shogan, Benjamin D.
AU - Hurst, Roger
AU - Hyman, Neil
AU - Rubin, David T.
AU - Sakuraba, Atsushi
N1 - Funding Information:
A.Y., F.K., H.H., D.M., L.C., B.S., K.U., R.S., R.H., and N.H.: none. Y.K. was supported by the Pediatric Oncology Research Fellowship of the Children’s Cancer Association of Japan. J.P.: research grants from Takeda and Abbvie, scientific advisory board for Pfizer and Janssen, consulting for Verastem. S.D.: investigator-initiated research grant from Pfizer. R.D.C.: consultant and/or scientific advisory board for Abbvie, Celgene, Entera Health, Hospi-ra, Janssen, Pfizer, Sandoz Biopharmaceuticals, Takeda, and UCB Pharma. Speaker’s bureau for Abbvie and Takeda. D.T.R.: consultant and grant support from Takeda, Janssen, and AbbVie, consultant for Pfizer and Amgen. A.S.: speaker’s bureau for Takeda.
Publisher Copyright:
© 2021
PY - 2021/9/1
Y1 - 2021/9/1
N2 - Background and Aims: Vitamin D deficiency has been associated with disease activity in Crohn's disease (CD). We assessed whether there is a correlation between vitamin D levels and the risk of postoperative recurrence in CD. Methods: CD patients who underwent surgery were identified from a prospectively maintained database at the University of Chicago. The primary endpoint was the correlation of serum 25-hydroxy vitamin D levels measured at 6-12 months after surgery and the proportion of patients in endoscopic remission, defined as a simple endoscopic score for CD of 0. Clinical, biological (C-reactive protein), and histologic recurrences were also studied. Results: Among a total of 89 patients, 17, 46, and 26 patients had vitamin D levels of <15, 15-30, and >30 ng/mL, respectively. Patients with higher vitamin D levels were significantly more likely to be in endoscopic remission compared to those with lower levels (23, 42, and 67% in ascending tertile order; p = 0.028). On multivariate analysis, vitamin D >30 ng/mL (odds ratio [OR] 0.22, 95% confidence interval [CI] 0.07-0.66, p = 0.006) and anti-tumor necrosis factor agent treatment (OR 0.25, 95% CI 0.08-0.83, p = 0.01) were associated with reduced risk of endoscopic recurrence. Rates of clinical, biological, and histologic remission trended to be higher in patients with higher vitamin D levels (p = 0.17, 0.55, 0.062, respectively). Conclusion: In the present study, higher vitamin D level was associated with lower risk of postoperative endoscopic CD recurrence. Further, studies are warranted to assess the role of vitamin D in postoperative CD recurrence.
AB - Background and Aims: Vitamin D deficiency has been associated with disease activity in Crohn's disease (CD). We assessed whether there is a correlation between vitamin D levels and the risk of postoperative recurrence in CD. Methods: CD patients who underwent surgery were identified from a prospectively maintained database at the University of Chicago. The primary endpoint was the correlation of serum 25-hydroxy vitamin D levels measured at 6-12 months after surgery and the proportion of patients in endoscopic remission, defined as a simple endoscopic score for CD of 0. Clinical, biological (C-reactive protein), and histologic recurrences were also studied. Results: Among a total of 89 patients, 17, 46, and 26 patients had vitamin D levels of <15, 15-30, and >30 ng/mL, respectively. Patients with higher vitamin D levels were significantly more likely to be in endoscopic remission compared to those with lower levels (23, 42, and 67% in ascending tertile order; p = 0.028). On multivariate analysis, vitamin D >30 ng/mL (odds ratio [OR] 0.22, 95% confidence interval [CI] 0.07-0.66, p = 0.006) and anti-tumor necrosis factor agent treatment (OR 0.25, 95% CI 0.08-0.83, p = 0.01) were associated with reduced risk of endoscopic recurrence. Rates of clinical, biological, and histologic remission trended to be higher in patients with higher vitamin D levels (p = 0.17, 0.55, 0.062, respectively). Conclusion: In the present study, higher vitamin D level was associated with lower risk of postoperative endoscopic CD recurrence. Further, studies are warranted to assess the role of vitamin D in postoperative CD recurrence.
KW - Crohn s disease
KW - Postoperative recurrence
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=85100711347&partnerID=8YFLogxK
U2 - 10.1159/000513589
DO - 10.1159/000513589
M3 - Article
C2 - 33556932
AN - SCOPUS:85100711347
VL - 102
SP - 767
EP - 775
JO - Digestion
JF - Digestion
SN - 0012-2823
IS - 5
ER -