The Correlation between Vitamin D Levels and the Risk of Postoperative Recurrence in Crohn's Disease

Akihiro Yamada, Yuga Komaki, Fukiko Komaki, Haider Haider, Dejan Micic, Joel Pekow, Sushila Dalal, Russell D. Cohen, Lisa Cannon, Konstantin Umanskiy, Radhika Smith, Benjamin D. Shogan, Roger Hurst, Neil Hyman, David T. Rubin, Atsushi Sakuraba

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background and Aims: Vitamin D deficiency has been associated with disease activity in Crohn's disease (CD). We assessed whether there is a correlation between vitamin D levels and the risk of postoperative recurrence in CD. Methods: CD patients who underwent surgery were identified from a prospectively maintained database at the University of Chicago. The primary endpoint was the correlation of serum 25-hydroxy vitamin D levels measured at 6-12 months after surgery and the proportion of patients in endoscopic remission, defined as a simple endoscopic score for CD of 0. Clinical, biological (C-reactive protein), and histologic recurrences were also studied. Results: Among a total of 89 patients, 17, 46, and 26 patients had vitamin D levels of <15, 15-30, and >30 ng/mL, respectively. Patients with higher vitamin D levels were significantly more likely to be in endoscopic remission compared to those with lower levels (23, 42, and 67% in ascending tertile order; p = 0.028). On multivariate analysis, vitamin D >30 ng/mL (odds ratio [OR] 0.22, 95% confidence interval [CI] 0.07-0.66, p = 0.006) and anti-tumor necrosis factor agent treatment (OR 0.25, 95% CI 0.08-0.83, p = 0.01) were associated with reduced risk of endoscopic recurrence. Rates of clinical, biological, and histologic remission trended to be higher in patients with higher vitamin D levels (p = 0.17, 0.55, 0.062, respectively). Conclusion: In the present study, higher vitamin D level was associated with lower risk of postoperative endoscopic CD recurrence. Further, studies are warranted to assess the role of vitamin D in postoperative CD recurrence.

Original languageEnglish
Pages (from-to)767-775
Number of pages9
Issue number5
StatePublished - Sep 1 2021


  • Crohn s disease
  • Postoperative recurrence
  • Vitamin D


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