TY - JOUR
T1 - The contribution of adult stem cells to renal repair
AU - Humphreys, Benjamin D.
AU - Bonventre, Joseph V.
N1 - Funding Information:
B.D.H. is supported by NIH Career Development Award DK73628. J.V.B. is supported by NIH grants DK72381, DK39773 and DK74099.
PY - 2007/3
Y1 - 2007/3
N2 - The kidney undergoes continuous, slow cellular turnover for tissue maintenance and rapid cell replacement after injury. The cellular origin of newly differentiated tubular epithelium remains controversial. In some non-renal organs, adult stem cells are recognized as the cell of origin for tissue replacement, such as the hematopoietic system, intestine and skin. These findings have prompted intense investigation for evidence of renal stem cells because of the great need for new therapeutic approaches to treat acute kidney injury and chronic kidney disease. Early excitement at reports that bone marrow-derived cells transdifferentiate into renal epithelial cells has been tempered by findings that show such events to be rare or potentially explained by cell fusion. More recent studies have focused on the possibility that renal progenitors exist within the kidney. In this review we compare data supporting the existence of adult renal stem cells with the body of evidence indicating that the kidney regenerates by self-duplication of differentiated cells. The identification of adult renal epithelial progenitor cells will ultimately determine the future direction of renal regenerative medicine.
AB - The kidney undergoes continuous, slow cellular turnover for tissue maintenance and rapid cell replacement after injury. The cellular origin of newly differentiated tubular epithelium remains controversial. In some non-renal organs, adult stem cells are recognized as the cell of origin for tissue replacement, such as the hematopoietic system, intestine and skin. These findings have prompted intense investigation for evidence of renal stem cells because of the great need for new therapeutic approaches to treat acute kidney injury and chronic kidney disease. Early excitement at reports that bone marrow-derived cells transdifferentiate into renal epithelial cells has been tempered by findings that show such events to be rare or potentially explained by cell fusion. More recent studies have focused on the possibility that renal progenitors exist within the kidney. In this review we compare data supporting the existence of adult renal stem cells with the body of evidence indicating that the kidney regenerates by self-duplication of differentiated cells. The identification of adult renal epithelial progenitor cells will ultimately determine the future direction of renal regenerative medicine.
KW - Bone marrow
KW - Progenitors
KW - Regeneration
KW - Reperfusion injury
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=33947408745&partnerID=8YFLogxK
U2 - 10.1016/j.nephro.2006.12.002
DO - 10.1016/j.nephro.2006.12.002
M3 - Short survey
C2 - 17383586
AN - SCOPUS:33947408745
SN - 1769-7255
VL - 3
SP - 3
EP - 10
JO - Nephrologie et Therapeutique
JF - Nephrologie et Therapeutique
IS - 1
ER -