TY - JOUR
T1 - The Consortium on Health and Ageing
T2 - Network of Cohorts in Europe and the United States (CHANCES) project—design, population and data harmonization of a large-scale, international study
AU - Boffetta, Paolo
AU - Bobak, Martin
AU - Borsch-Supan, Axel
AU - Brenner, Hermann
AU - Eriksson, Sture
AU - Grodstein, Fran
AU - Jansen, Eugene
AU - Jenab, Mazda
AU - Juerges, Hendrik
AU - Kampman, Ellen
AU - Kee, Frank
AU - Kuulasmaa, Kari
AU - Park, Yikyung
AU - Tjonneland, Anne
AU - van Duijn, Cornelia
AU - Wilsgaard, Tom
AU - Wolk, Alicja
AU - Trichopoulos, Dimitrios
AU - Bamia, Christina
AU - Trichopoulou, Antonia
N1 - Publisher Copyright:
© 2014, Springer Science+Business Media Dordrecht.
PY - 2014/12/28
Y1 - 2014/12/28
N2 - There is a public health demand to prevent health conditions which lead to increased morbidity and mortality among the rapidly-increasing elderly population. Data for the incidence of such conditions exist in cohort studies worldwide, which, however, differ in various aspects. The Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES) project aims at harmonizing data from existing major longitudinal studies for the elderly whilst focussing on cardiovascular diseases, diabetes mellitus, cancer, fractures and cognitive impairment in order to estimate their prevalence, incidence and cause-specific mortality, and identify lifestyle, socioeconomic, and genetic determinants and biomarkers for the incidence of and mortality from these conditions. A survey instrument assessing ageing-related conditions of the elderly will be also developed. Fourteen cohort studies participate in CHANCES with 683,228 elderly (and 150,210 deaths), from 23 European and three non-European countries. So far, 287 variables on health conditions and a variety of exposures, including biomarkers and genetic data have been harmonized. Different research hypotheses are investigated with meta-analyses. The results which will be produced can help international organizations, governments and policy-makers to better understand the broader implications and consequences of ageing and thus make informed decisions.
AB - There is a public health demand to prevent health conditions which lead to increased morbidity and mortality among the rapidly-increasing elderly population. Data for the incidence of such conditions exist in cohort studies worldwide, which, however, differ in various aspects. The Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES) project aims at harmonizing data from existing major longitudinal studies for the elderly whilst focussing on cardiovascular diseases, diabetes mellitus, cancer, fractures and cognitive impairment in order to estimate their prevalence, incidence and cause-specific mortality, and identify lifestyle, socioeconomic, and genetic determinants and biomarkers for the incidence of and mortality from these conditions. A survey instrument assessing ageing-related conditions of the elderly will be also developed. Fourteen cohort studies participate in CHANCES with 683,228 elderly (and 150,210 deaths), from 23 European and three non-European countries. So far, 287 variables on health conditions and a variety of exposures, including biomarkers and genetic data have been harmonized. Different research hypotheses are investigated with meta-analyses. The results which will be produced can help international organizations, governments and policy-makers to better understand the broader implications and consequences of ageing and thus make informed decisions.
KW - Ageing
KW - Cohort
KW - Elderly
KW - Meta-analysis
UR - http://www.scopus.com/inward/record.url?scp=84925497834&partnerID=8YFLogxK
U2 - 10.1007/s10654-014-9977-1
DO - 10.1007/s10654-014-9977-1
M3 - Article
C2 - 25504016
AN - SCOPUS:84925497834
SN - 0393-2990
VL - 29
SP - 929
EP - 936
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
IS - 12
ER -