Altered brain development has been highlighted as an important contributor to adverse neurodevelopmental outcomes in children with congenital heart disease. Abnormalities begin prenatally and include micro- and macrostructural disturbances that lead to an altered trajectory of brain growth throughout gestation. Recent progress in fetal imaging has improved understanding of the neurobiological mechanisms and risk factors for impaired fetal brain development. The impact of the prenatal environment on postnatal neurological care has also gained increased focus. This review summarizes current data on the timing and pattern of altered prenatal brain development in congenital heart disease, the potential mechanisms of these abnormalities, and the association with perioperative neurological complications.

Original languageEnglish
Pages (from-to)23-30
Number of pages8
JournalPediatric Neurology
StatePublished - Jul 2020


  • Brain
  • Brain development
  • Brain injury
  • Congenital heart disease
  • Fetal
  • Prenatal


Dive into the research topics of 'The Congenital Heart Disease Brain: Prenatal Considerations for Perioperative Neurocritical Care'. Together they form a unique fingerprint.

Cite this