@article{ec5725d87a82468bb354fa5314031252,
title = "The Congenital Heart Disease Brain: Prenatal Considerations for Perioperative Neurocritical Care",
abstract = "Altered brain development has been highlighted as an important contributor to adverse neurodevelopmental outcomes in children with congenital heart disease. Abnormalities begin prenatally and include micro- and macrostructural disturbances that lead to an altered trajectory of brain growth throughout gestation. Recent progress in fetal imaging has improved understanding of the neurobiological mechanisms and risk factors for impaired fetal brain development. The impact of the prenatal environment on postnatal neurological care has also gained increased focus. This review summarizes current data on the timing and pattern of altered prenatal brain development in congenital heart disease, the potential mechanisms of these abnormalities, and the association with perioperative neurological complications.",
keywords = "Brain, Brain development, Brain injury, Congenital heart disease, Fetal, Prenatal",
author = "Ortinau, {Cynthia M.} and Shimony, {Joshua S.}",
note = "Funding Information: This work was supported by the National Institutes of Health / National Heart, Lung, and Blood Institute ( K23HL141602 ), the Eunice Kennedy Shriver National Institute Of Child Health & Human Development of the National Institutes of Health under Award Number U54 HD087011 to the Intellectual and Developmental Disabilities Research Center at Washington University, and the Children{\textquoteright}s Discovery Institute of Washington University and St. Louis Children{\textquoteright}s Hospital. The content of this work is solely the responsibility of the author and does not necessarily represent the official views of the National Institutes of Health. Funding Information: This work was supported by the National Institutes of Health/National Heart, Lung, and Blood Institute (K23HL141602), the Eunice Kennedy Shriver National Institute Of Child Health & Human Development of the National Institutes of Health under Award Number U54 HD087011 to the Intellectual and Developmental Disabilities Research Center at Washington University, and the Children's Discovery Institute of Washington University and St. Louis Children's Hospital. The content of this work is solely the responsibility of the author and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = jul,
doi = "10.1016/j.pediatrneurol.2020.01.002",
language = "English",
volume = "108",
pages = "23--30",
journal = "Pediatric Neurology",
issn = "0887-8994",
}