TY - JOUR
T1 - The Comprehensive Assessment of Self-Reported Urinary Symptoms
T2 - A New Tool for Research on Subtypes of Patients with Lower Urinary Tract Symptoms
AU - LURN Study Group
AU - Weinfurt, Kevin P.
AU - Griffith, James W.
AU - Flynn, Kathryn E.
AU - Cella, David
AU - Bavendam, Tamara
AU - Wiseman, Jonathan B.
AU - Andreev, Victor P.
AU - Lai, H. Henry
AU - Liu, Alice B.
AU - Kirkali, Ziya
AU - Cameron, Anne P.
AU - Bradley, Catherine S.
N1 - Funding Information:
Accepted for publication December 29, 2018. The corresponding author certifies that, when applicable, a statement(s) has been included in the manuscript documenting institutional review board, ethics committee or ethical review board study approval; principles of Helsinki Declaration were followed in lieu of formal ethics committee approval; institutional animal care and use committee approval; all human subjects provided written informed consent with guarantees of confidentiality; IRB approved protocol number; animal approved project number. Supported by NIDDK cooperative agreements (Grants DK097780, DK097772, DK097779, DK099932, DK100011, DK100017, DK097776, DK099879), NIDDK Grant K23-DK110417 and in part by NIH (National Institutes of Health) NCATS (National Center for Advancing Translational Sciences) Grant UL1TR001422. This is publication number 15 of the LURN. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. No direct or indirect commercial, personal, academic, political, religious or ethical incentive is associated with publishing this article. * Correspondence: Department of Population Health Sciences, Duke University School of Medicine, 215 Morris St., Box 104023, Durham, North Carolina 27705 (telephone: 919-668-8019; email: Kevin.Weinfurt@duke.edu).
Funding Information:
Karl Kreder and Catherine S. Bradley, Co-Is Bradley A. Erickson, Susan K. Lutgendorf, Vince Magnotta, Michael A. O’Donnell and Vivian Sung, and Study Coordinator Ahmad Alzubaidi, University of Iowa, Iowa City, Iowa (NIDDK Grant DK097772); PI David Cella, Co-Is James W. Griff ith, Kimberly Kenton, Christina Lewicky-Gaupp, Todd Parrish, Jennie Yufen Chen and Margaret Mueller, Study Coordinators Sarah Buono, Maria Corona, Beatriz Menendez, Alexis Siurek, Meera Tavathia, Veronica Venezuela and Azra Muftic, Northwestern University and PI Brian Helfand, and Study Coordinators Pooja Talaty and Jasmine Nero, NorthShore University HealthSystem, Chicago, Illinois (NIDDK Grant DK097779); PI J. Quentin Clemens, Co-Is Mitch Berger, John DeLancey, Dee Fenner, Rick Harris, Steve Harte, Anne P. Cameron and John Wei, and Study Coordinators Morgen Barroso, Linda Drnek, Greg Mowatt and Julie Tumbarello, University of Michigan Health System (NIDDK Grant DK099932) and PI Robert Merion, Co-Is Victor Andreev, Brenda Gillespie, Gang Liu and Abigail Smith, Project Manager Melissa Fava, Clinical Study Process Manager Peg Hill-Callahan, Clinical Monitor Timothy Buck, Research Analysts Margaret Helmuth and Jon Wiseman, and Project Associate Julieanne Lock, Data Coordinating Center, Arbor Research Collaborative for Health (NIDDK Grants DK097776 and DK099879), Ann Arbor, Michigan; PI Claire Yang, Co-I John L. Gore and Study Coordinators Alice Liu and Brenda Vicars, Washington University in St. Louis, St. Louis, Missouri (NIDDK Grant DK100017); PIs Gerald L. Andriole and H. Henry Lai, Co-I Joshua Shimony and Study Coordinators Susan Mueller, Heather Wilson, Deborah Ksiazek and Aleksandra Klim, University of Washington, Seattle, Washington (NIDDK Grant DK100011); Project Scientist Ziya Kirkali, Project Officer John Kusek and NIH (National Institutes of Health) Personnel Tamara Baven-dam, Robert Star and Jenna Norton, Division of Kidney, Urology and Hematology, NIDDK, Bethesda, Maryland.
Publisher Copyright:
© 2019 by American Urological Association Education and Research, Inc.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Purpose: To improve the potential for finding clinically important subtypes of patients with lower urinary tract symptoms we developed the CASUS (Comprehensive Assessment of Self-reported Urinary Symptoms). We used it to present data on the experiences of lower urinary tract symptoms in treatment seeking women and men from a prospective observational cohort. Materials and Methods: We created an initial list of lower urinary tract symptoms that were confirmed in 22 qualitative interviews with providers, and 88 qualitative interviews with care seeking and noncare seeking women and men with lower urinary tract symptoms. Items from extant measures were adopted and revised, and new items were developed. All items were evaluated for understanding in 64 cognitive interviews. Items were administered to a prospective cohort of female and male patients with lower urinary tract symptoms who were seeking care. Analyses were done to describe item response distributions and correlations among item responses separately for women and men. Results: A total of 444 males and 372 females provided responses to the CASUS. Several sets of items showed different relationships for women compared to men. In particular the associations between sensation related items and incontinence related items were generally positive among females but often negative among males. Conclusions: After using an intensive development process the CASUS addresses a wide range of lower urinary tract symptoms. It should help identify clinically important subtypes of patients. Further, item collection can provide the foundation for shorter measures for use in the clinic and as trial end points.
AB - Purpose: To improve the potential for finding clinically important subtypes of patients with lower urinary tract symptoms we developed the CASUS (Comprehensive Assessment of Self-reported Urinary Symptoms). We used it to present data on the experiences of lower urinary tract symptoms in treatment seeking women and men from a prospective observational cohort. Materials and Methods: We created an initial list of lower urinary tract symptoms that were confirmed in 22 qualitative interviews with providers, and 88 qualitative interviews with care seeking and noncare seeking women and men with lower urinary tract symptoms. Items from extant measures were adopted and revised, and new items were developed. All items were evaluated for understanding in 64 cognitive interviews. Items were administered to a prospective cohort of female and male patients with lower urinary tract symptoms who were seeking care. Analyses were done to describe item response distributions and correlations among item responses separately for women and men. Results: A total of 444 males and 372 females provided responses to the CASUS. Several sets of items showed different relationships for women compared to men. In particular the associations between sensation related items and incontinence related items were generally positive among females but often negative among males. Conclusions: After using an intensive development process the CASUS addresses a wide range of lower urinary tract symptoms. It should help identify clinically important subtypes of patients. Further, item collection can provide the foundation for shorter measures for use in the clinic and as trial end points.
KW - lower urinary tract symptoms
KW - patient acceptance of health care
KW - patient reported outcome measures
KW - surveys and questionnaires
KW - urinary bladder
UR - http://www.scopus.com/inward/record.url?scp=85065807426&partnerID=8YFLogxK
U2 - 10.1097/JU.0000000000000140
DO - 10.1097/JU.0000000000000140
M3 - Article
C2 - 30730410
AN - SCOPUS:85065807426
SN - 0022-5347
VL - 201
SP - 1177
EP - 1183
JO - The Journal of Urology
JF - The Journal of Urology
IS - 6
ER -