TY - JOUR
T1 - The combinatorics of neurite self-avoidance
AU - Forbes, Elizabeth M.
AU - Hunt, Jonathan J.
AU - Goodhill, Geoffrey J.
PY - 2011
Y1 - 2011
N2 - During neural development in Drosophila, the ability of neurite branches to recognizewhether they are from the same or different neurons depends crucially on the moleculeDscam1. In particular, this recognition depends on the stochastic acquisition of a unique combination ofDscam1 isoforms out of a large set of possible isoforms. To properly interpret these findings, it is crucial to understand the combinatorics involved, which has previously been attempted only using stochastic simulations for some specific parameter combinations. Here we present closed-form solutions for the general case. These reveal the relationships among the key variables and how these constrain possible biological scenarios.
AB - During neural development in Drosophila, the ability of neurite branches to recognizewhether they are from the same or different neurons depends crucially on the moleculeDscam1. In particular, this recognition depends on the stochastic acquisition of a unique combination ofDscam1 isoforms out of a large set of possible isoforms. To properly interpret these findings, it is crucial to understand the combinatorics involved, which has previously been attempted only using stochastic simulations for some specific parameter combinations. Here we present closed-form solutions for the general case. These reveal the relationships among the key variables and how these constrain possible biological scenarios.
UR - http://www.scopus.com/inward/record.url?scp=80053951803&partnerID=8YFLogxK
U2 - 10.1162/NECO_a_00186
DO - 10.1162/NECO_a_00186
M3 - Letter
C2 - 21732864
AN - SCOPUS:80053951803
SN - 0899-7667
VL - 23
SP - 2746
EP - 2769
JO - Neural Computation
JF - Neural Computation
IS - 11
ER -