The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 165 Patients with Tubercular Anterior Uveitis

Rupesh Agrawal; Bjorn Betzler; Ilaria Testi; Sarakshi Mahajan; Aniruddha Agarwal; Dinesh Visva Gunasekeran; Dhananjay Raje; Kanika Aggarwal; Somasheila I. Murthy; Mark Westcott; Soon Phaik Chee; Peter Mccluskey; Su Ling Ho; Stephen Teoh; Luca Cimino; Jyotirmay Biswas; Shishir Narain; Manisha Agarwal; Padmamalini Mahendradas; Moncef Khairallah; Nicholas Jones; Ilknur Tugal-Tutkun; Kalpana Babu; Soumayava Basu; Ester Carreño; Richard Lee; Hassan Al-Dhibi; Bahram Bodaghi; Alessandro Invernizzi; Debra A. Goldstein; Carl P. Herbort; Talin Barisani-Asenbauer; Julio J. González-López; Sofia Androudi; Reema Bansal; Bruttendu Moharana; Simona Esposti; Anastasia Tasiopoulou; Sengal Nadarajah; Mamta Agarwal; Sharanya Abraham; Ruchi Vala; Ramandeep Singh; Aman Sharma; Kusum Sharma; Manfred Zierhut; Onn Min Kon; Emmett T. Cunningham; John H. Kempen; Quan Dong Nguyen; Carlos Pavesio; Vishali Gupta

doi:10.1080/09273948.2020.1761400

The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 165 Patients with Tubercular Anterior Uveitis

Rupesh Agrawal, Bjorn Betzler, Ilaria Testi, Sarakshi Mahajan, Aniruddha Agarwal, Dinesh Visva Gunasekeran, Dhananjay Raje, Kanika Aggarwal, Somasheila I. Murthy, Mark Westcott, Soon Phaik Chee, Peter Mccluskey, Su Ling Ho, Stephen Teoh, Luca Cimino, Jyotirmay Biswas, Shishir Narain, Manisha Agarwal, Padmamalini Mahendradas, Moncef KhairallahNicholas Jones, Ilknur Tugal-Tutkun, Kalpana Babu, Soumayava Basu, Ester Carreño, Richard Lee, Hassan Al-Dhibi, Bahram Bodaghi, Alessandro Invernizzi, Debra A. Goldstein, Carl P. Herbort, Talin Barisani-Asenbauer, Julio J. González-López, Sofia Androudi, Reema Bansal, Bruttendu Moharana, Simona Esposti, Anastasia Tasiopoulou, Sengal Nadarajah, Mamta Agarwal, Sharanya Abraham, Ruchi Vala, Ramandeep Singh, Aman Sharma, Kusum Sharma, Manfred Zierhut, Onn Min Kon, Emmett T. Cunningham, John H. Kempen, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta

Division of Hospital Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Purpose: The Collaborative Ocular Tuberculosis Study (COTS) Group sought to address the diagnostic uncertainty through retrospective cohort analysis of treatment regimens and therapeutic outcomes for patients with tubercular Anterior Uveitis (TAU) across international centers. Methods: Multicentre retrospective analysis of patients diagnosed with TAU between January 2004 to December 2014 that had a minimum follow-up of 1 year. Results: One hundred and sixty-five patients were included. One hundred and seven subjects received antitubercular therapy (ATT) (n = 107/165; 64.9%) with all the patients receiving topical steroid therapy. Treatment failure was noted in 17 patients (n = 17/165; 10.3%), more frequently described in patients that received ATT (n = 13/107, 12.2%), than those that did not receive ATT (n = 4/58, 6.9%). Conclusion: In this retrospective study, addition of ATT did not have any statistically significant impact on outcome in patients with TAU.

Original language	English
Pages (from-to)	1-10
Number of pages	10
Journal	Ocular Immunology and Inflammation
DOIs	https://doi.org/10.1080/09273948.2020.1761400
State	Published - 2020

Keywords

Anti-tubercular therapy
collaborative ocular tuberculosis study (COTS)
ocular tuberculosis
tubercular anterior uveitis
uveitis

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10.1080/09273948.2020.1761400

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Agrawal, R., Betzler, B., Testi, I., Mahajan, S., Agarwal, A., Gunasekeran, D. V., Raje, D., Aggarwal, K., Murthy, S. I., Westcott, M., Chee, S. P., Mccluskey, P., Ho, S. L., Teoh, S., Cimino, L., Biswas, J., Narain, S., Agarwal, M., Mahendradas, P., ... Gupta, V. (2020). The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 165 Patients with Tubercular Anterior Uveitis. Ocular Immunology and Inflammation, 1-10. https://doi.org/10.1080/09273948.2020.1761400

@article{8bd34396f82d4dcab0a34a368a4fc686,

title = "The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 165 Patients with Tubercular Anterior Uveitis",

abstract = "Purpose: The Collaborative Ocular Tuberculosis Study (COTS) Group sought to address the diagnostic uncertainty through retrospective cohort analysis of treatment regimens and therapeutic outcomes for patients with tubercular Anterior Uveitis (TAU) across international centers. Methods: Multicentre retrospective analysis of patients diagnosed with TAU between January 2004 to December 2014 that had a minimum follow-up of 1 year. Results: One hundred and sixty-five patients were included. One hundred and seven subjects received antitubercular therapy (ATT) (n = 107/165; 64.9%) with all the patients receiving topical steroid therapy. Treatment failure was noted in 17 patients (n = 17/165; 10.3%), more frequently described in patients that received ATT (n = 13/107, 12.2%), than those that did not receive ATT (n = 4/58, 6.9%). Conclusion: In this retrospective study, addition of ATT did not have any statistically significant impact on outcome in patients with TAU.",

keywords = "Anti-tubercular therapy, collaborative ocular tuberculosis study (COTS), ocular tuberculosis, tubercular anterior uveitis, uveitis",

author = "Rupesh Agrawal and Bjorn Betzler and Ilaria Testi and Sarakshi Mahajan and Aniruddha Agarwal and Gunasekeran, {Dinesh Visva} and Dhananjay Raje and Kanika Aggarwal and Murthy, {Somasheila I.} and Mark Westcott and Chee, {Soon Phaik} and Peter Mccluskey and Ho, {Su Ling} and Stephen Teoh and Luca Cimino and Jyotirmay Biswas and Shishir Narain and Manisha Agarwal and Padmamalini Mahendradas and Moncef Khairallah and Nicholas Jones and Ilknur Tugal-Tutkun and Kalpana Babu and Soumayava Basu and Ester Carre{\~n}o and Richard Lee and Hassan Al-Dhibi and Bahram Bodaghi and Alessandro Invernizzi and Goldstein, {Debra A.} and Herbort, {Carl P.} and Talin Barisani-Asenbauer and Gonz{\'a}lez-L{\'o}pez, {Julio J.} and Sofia Androudi and Reema Bansal and Bruttendu Moharana and Simona Esposti and Anastasia Tasiopoulou and Sengal Nadarajah and Mamta Agarwal and Sharanya Abraham and Ruchi Vala and Ramandeep Singh and Aman Sharma and Kusum Sharma and Manfred Zierhut and Kon, {Onn Min} and Cunningham, {Emmett T.} and Kempen, {John H.} and Nguyen, {Quan Dong} and Carlos Pavesio and Vishali Gupta",

note = "Publisher Copyright: {\textcopyright} 2020, {\textcopyright} 2020 Taylor & Francis Group, LLC.",

year = "2020",

doi = "10.1080/09273948.2020.1761400",

language = "English",

pages = "1--10",

journal = "Ocular Immunology and Inflammation",

issn = "0927-3948",

}

Agrawal, R, Betzler, B, Testi, I, Mahajan, S, Agarwal, A, Gunasekeran, DV, Raje, D, Aggarwal, K, Murthy, SI, Westcott, M, Chee, SP, Mccluskey, P, Ho, SL, Teoh, S, Cimino, L, Biswas, J, Narain, S, Agarwal, M, Mahendradas, P, Khairallah, M, Jones, N, Tugal-Tutkun, I, Babu, K, Basu, S, Carreño, E, Lee, R, Al-Dhibi, H, Bodaghi, B, Invernizzi, A, Goldstein, DA, Herbort, CP, Barisani-Asenbauer, T, González-López, JJ, Androudi, S, Bansal, R, Moharana, B, Esposti, S, Tasiopoulou, A, Nadarajah, S, Agarwal, M, Abraham, S, Vala, R, Singh, R, Sharma, A, Sharma, K, Zierhut, M, Kon, OM, Cunningham, ET, Kempen, JH, Nguyen, QD, Pavesio, C & Gupta, V 2020, 'The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 165 Patients with Tubercular Anterior Uveitis', Ocular Immunology and Inflammation, pp. 1-10. https://doi.org/10.1080/09273948.2020.1761400

TY - JOUR

T1 - The Collaborative Ocular Tuberculosis Study (COTS)-1

T2 - A Multinational Review of 165 Patients with Tubercular Anterior Uveitis

AU - Agrawal, Rupesh

AU - Betzler, Bjorn

AU - Testi, Ilaria

AU - Mahajan, Sarakshi

AU - Agarwal, Aniruddha

AU - Gunasekeran, Dinesh Visva

AU - Raje, Dhananjay

AU - Aggarwal, Kanika

AU - Murthy, Somasheila I.

AU - Westcott, Mark

AU - Chee, Soon Phaik

AU - Mccluskey, Peter

AU - Ho, Su Ling

AU - Teoh, Stephen

AU - Cimino, Luca

AU - Biswas, Jyotirmay

AU - Narain, Shishir

AU - Agarwal, Manisha

AU - Mahendradas, Padmamalini

AU - Khairallah, Moncef

AU - Jones, Nicholas

AU - Tugal-Tutkun, Ilknur

AU - Babu, Kalpana

AU - Basu, Soumayava

AU - Carreño, Ester

AU - Lee, Richard

AU - Al-Dhibi, Hassan

AU - Bodaghi, Bahram

AU - Invernizzi, Alessandro

AU - Goldstein, Debra A.

AU - Herbort, Carl P.

AU - Barisani-Asenbauer, Talin

AU - González-López, Julio J.

AU - Androudi, Sofia

AU - Bansal, Reema

AU - Moharana, Bruttendu

AU - Esposti, Simona

AU - Tasiopoulou, Anastasia

AU - Nadarajah, Sengal

AU - Agarwal, Mamta

AU - Abraham, Sharanya

AU - Vala, Ruchi

AU - Singh, Ramandeep

AU - Sharma, Aman

AU - Sharma, Kusum

AU - Zierhut, Manfred

AU - Kon, Onn Min

AU - Cunningham, Emmett T.

AU - Kempen, John H.

AU - Nguyen, Quan Dong

AU - Pavesio, Carlos

AU - Gupta, Vishali

PY - 2020

Y1 - 2020

N2 - Purpose: The Collaborative Ocular Tuberculosis Study (COTS) Group sought to address the diagnostic uncertainty through retrospective cohort analysis of treatment regimens and therapeutic outcomes for patients with tubercular Anterior Uveitis (TAU) across international centers. Methods: Multicentre retrospective analysis of patients diagnosed with TAU between January 2004 to December 2014 that had a minimum follow-up of 1 year. Results: One hundred and sixty-five patients were included. One hundred and seven subjects received antitubercular therapy (ATT) (n = 107/165; 64.9%) with all the patients receiving topical steroid therapy. Treatment failure was noted in 17 patients (n = 17/165; 10.3%), more frequently described in patients that received ATT (n = 13/107, 12.2%), than those that did not receive ATT (n = 4/58, 6.9%). Conclusion: In this retrospective study, addition of ATT did not have any statistically significant impact on outcome in patients with TAU.

AB - Purpose: The Collaborative Ocular Tuberculosis Study (COTS) Group sought to address the diagnostic uncertainty through retrospective cohort analysis of treatment regimens and therapeutic outcomes for patients with tubercular Anterior Uveitis (TAU) across international centers. Methods: Multicentre retrospective analysis of patients diagnosed with TAU between January 2004 to December 2014 that had a minimum follow-up of 1 year. Results: One hundred and sixty-five patients were included. One hundred and seven subjects received antitubercular therapy (ATT) (n = 107/165; 64.9%) with all the patients receiving topical steroid therapy. Treatment failure was noted in 17 patients (n = 17/165; 10.3%), more frequently described in patients that received ATT (n = 13/107, 12.2%), than those that did not receive ATT (n = 4/58, 6.9%). Conclusion: In this retrospective study, addition of ATT did not have any statistically significant impact on outcome in patients with TAU.

KW - Anti-tubercular therapy

KW - collaborative ocular tuberculosis study (COTS)

KW - ocular tuberculosis

KW - tubercular anterior uveitis

KW - uveitis

UR - http://www.scopus.com/inward/record.url?scp=85087505413&partnerID=8YFLogxK

U2 - 10.1080/09273948.2020.1761400

DO - 10.1080/09273948.2020.1761400

M3 - Article

C2 - 32600163

AN - SCOPUS:85087505413

SN - 0927-3948

SP - 1

EP - 10

JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

ER -

The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 165 Patients with Tubercular Anterior Uveitis

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