The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Descriptive Review of Tubercular Uveitis in Paediatric Population

Ilaria Testi; Rupesh Agrawal; Sarakshi Mahajan; Aniruddha Agarwal; Dinesh Visva Gunasekeran; Dhananjay Raje; Kanika Aggarwal; Somasheila I. Murthy; Mark Westcott; Soon Phaik Chee; Peter Mccluskey; Su Ling Ho; Stephen Teoh; Luca Cimino; Jyotirmay Biswas; Shishir Narain; Manisha Agarwal; Padmamalini Mahendradas; Moncef Khairallah; Nicholas Jones; Ilknur Tugal-Tutkun; Kalpana Babu; Soumayava Basu; Ester Carreño; Richard Lee; Hassan Al-Dhibi; Bahram Bodaghi; Alessandro Invernizzi; Debra A. Goldstein; Carl P. Herbort; Talin Barisani-Asenbauer; Julio J. González-López; Sofia Androudi; Reema Bansal; Bruttendu Moharana; Simona Degli Esposti; Anastasia Tasiopoulou; Sengal Nadarajah; Mamta Agarwal; Sharanaya Abraham; Ruchi Vala; Ramandeep Singh; Aman Sharma; Kusum Sharma; Manfred Zierhut; Onn Min Kon; Emmett T. Cunningham; John H. Kempen; Quan Dong Nguyen; Carlos Pavesio; Vishali Gupta

doi:10.1080/09273948.2020.1781197

The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Descriptive Review of Tubercular Uveitis in Paediatric Population

Ilaria Testi, Rupesh Agrawal, Sarakshi Mahajan, Aniruddha Agarwal, Dinesh Visva Gunasekeran, Dhananjay Raje, Kanika Aggarwal, Somasheila I. Murthy, Mark Westcott, Soon Phaik Chee, Peter Mccluskey, Su Ling Ho, Stephen Teoh, Luca Cimino, Jyotirmay Biswas, Shishir Narain, Manisha Agarwal, Padmamalini Mahendradas, Moncef Khairallah, Nicholas JonesIlknur Tugal-Tutkun, Kalpana Babu, Soumayava Basu, Ester Carreño, Richard Lee, Hassan Al-Dhibi, Bahram Bodaghi, Alessandro Invernizzi, Debra A. Goldstein, Carl P. Herbort, Talin Barisani-Asenbauer, Julio J. González-López, Sofia Androudi, Reema Bansal, Bruttendu Moharana, Simona Degli Esposti, Anastasia Tasiopoulou, Sengal Nadarajah, Mamta Agarwal, Sharanaya Abraham, Ruchi Vala, Ramandeep Singh, Aman Sharma, Kusum Sharma, Manfred Zierhut, Onn Min Kon, Emmett T. Cunningham, John H. Kempen, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta

Division of Hospital Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Purpose: To examine disease profile of tubercular uveitis (TBU) in Paediatric population. Methods: Among 945 patients of the retrospective multinational study by the Collaborative Ocular Tuberculosis Study (COTS)-1, 29 Paediatric patients diagnosed with TBU were analyzed. Results: Mean age of disease presentation was 12.8 (range 4–18 years), with predominance of males (n = 14/20; 70.0%) and Asian ethnicity (n = 25/29; 86.2%). Posterior uveitis (n = 14/28; 50%) was the most frequent uveitis phenotype, with choroidal involvement occurring in 64.7% (n = 11/17). Incidence of optic disc edema and macular edema was higher in children (n = 8/18; 44.4% and n = 5/18; 27.8%, respectively) than in adults (n = 160/942; 16.9% and n = 135/942; 14.3%, respectively). Comparison of optic disc edema between subgroups showed a significant difference (P =.006). All patients received oral corticosteroids, most of them with antitubercular therapy. Treatment failure developed in 4.8% (n = 1/21). Conclusions: Children have a more severe inflammatory response to the disease, and an intensive anti-inflammatory therapeutic regimen is required to achieve a positive treatment outcome.

Original language	English
Pages (from-to)	58-64
Number of pages	7
Journal	Ocular Immunology and Inflammation
Volume	28
Issue number	sup1
DOIs	https://doi.org/10.1080/09273948.2020.1781197
State	Published - 2020

Keywords

Collaborative Ocular Tuberculosis Study (COTS)
Ocular tuberculosis
children
pediatric population
tubercular uveitis

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10.1080/09273948.2020.1781197

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Testi, I., Agrawal, R., Mahajan, S., Agarwal, A., Gunasekeran, D. V., Raje, D., Aggarwal, K., Murthy, S. I., Westcott, M., Chee, S. P., Mccluskey, P., Ho, S. L., Teoh, S., Cimino, L., Biswas, J., Narain, S., Agarwal, M., Mahendradas, P., Khairallah, M., ... Gupta, V. (2020). The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Descriptive Review of Tubercular Uveitis in Paediatric Population. Ocular Immunology and Inflammation, 28(sup1), 58-64. https://doi.org/10.1080/09273948.2020.1781197

@article{a3d0a9d1faf64c009913d1f13d3bb458,

title = "The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Descriptive Review of Tubercular Uveitis in Paediatric Population",

abstract = "Purpose: To examine disease profile of tubercular uveitis (TBU) in Paediatric population. Methods: Among 945 patients of the retrospective multinational study by the Collaborative Ocular Tuberculosis Study (COTS)-1, 29 Paediatric patients diagnosed with TBU were analyzed. Results: Mean age of disease presentation was 12.8 (range 4–18 years), with predominance of males (n = 14/20; 70.0%) and Asian ethnicity (n = 25/29; 86.2%). Posterior uveitis (n = 14/28; 50%) was the most frequent uveitis phenotype, with choroidal involvement occurring in 64.7% (n = 11/17). Incidence of optic disc edema and macular edema was higher in children (n = 8/18; 44.4% and n = 5/18; 27.8%, respectively) than in adults (n = 160/942; 16.9% and n = 135/942; 14.3%, respectively). Comparison of optic disc edema between subgroups showed a significant difference (P =.006). All patients received oral corticosteroids, most of them with antitubercular therapy. Treatment failure developed in 4.8% (n = 1/21). Conclusions: Children have a more severe inflammatory response to the disease, and an intensive anti-inflammatory therapeutic regimen is required to achieve a positive treatment outcome.",

keywords = "Collaborative Ocular Tuberculosis Study (COTS), Ocular tuberculosis, children, pediatric population, tubercular uveitis",

author = "Ilaria Testi and Rupesh Agrawal and Sarakshi Mahajan and Aniruddha Agarwal and Gunasekeran, {Dinesh Visva} and Dhananjay Raje and Kanika Aggarwal and Murthy, {Somasheila I.} and Mark Westcott and Chee, {Soon Phaik} and Peter Mccluskey and Ho, {Su Ling} and Stephen Teoh and Luca Cimino and Jyotirmay Biswas and Shishir Narain and Manisha Agarwal and Padmamalini Mahendradas and Moncef Khairallah and Nicholas Jones and Ilknur Tugal-Tutkun and Kalpana Babu and Soumayava Basu and Ester Carre{\~n}o and Richard Lee and Hassan Al-Dhibi and Bahram Bodaghi and Alessandro Invernizzi and Goldstein, {Debra A.} and Herbort, {Carl P.} and Talin Barisani-Asenbauer and Gonz{\'a}lez-L{\'o}pez, {Julio J.} and Sofia Androudi and Reema Bansal and Bruttendu Moharana and Esposti, {Simona Degli} and Anastasia Tasiopoulou and Sengal Nadarajah and Mamta Agarwal and Sharanaya Abraham and Ruchi Vala and Ramandeep Singh and Aman Sharma and Kusum Sharma and Manfred Zierhut and Kon, {Onn Min} and Cunningham, {Emmett T.} and Kempen, {John H.} and Nguyen, {Quan Dong} and Carlos Pavesio and Vishali Gupta",

note = "Publisher Copyright: {\textcopyright} 2020 Taylor & Francis Group, LLC.",

year = "2020",

doi = "10.1080/09273948.2020.1781197",

language = "English",

volume = "28",

pages = "58--64",

journal = "Ocular Immunology and Inflammation",

issn = "0927-3948",

number = "sup1",

}

Testi, I, Agrawal, R, Mahajan, S, Agarwal, A, Gunasekeran, DV, Raje, D, Aggarwal, K, Murthy, SI, Westcott, M, Chee, SP, Mccluskey, P, Ho, SL, Teoh, S, Cimino, L, Biswas, J, Narain, S, Agarwal, M, Mahendradas, P, Khairallah, M, Jones, N, Tugal-Tutkun, I, Babu, K, Basu, S, Carreño, E, Lee, R, Al-Dhibi, H, Bodaghi, B, Invernizzi, A, Goldstein, DA, Herbort, CP, Barisani-Asenbauer, T, González-López, JJ, Androudi, S, Bansal, R, Moharana, B, Esposti, SD, Tasiopoulou, A, Nadarajah, S, Agarwal, M, Abraham, S, Vala, R, Singh, R, Sharma, A, Sharma, K, Zierhut, M, Kon, OM, Cunningham, ET, Kempen, JH, Nguyen, QD, Pavesio, C & Gupta, V 2020, 'The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Descriptive Review of Tubercular Uveitis in Paediatric Population', Ocular Immunology and Inflammation, vol. 28, no. sup1, pp. 58-64. https://doi.org/10.1080/09273948.2020.1781197

TY - JOUR

T1 - The Collaborative Ocular Tuberculosis Study (COTS)-1

T2 - A Multinational Descriptive Review of Tubercular Uveitis in Paediatric Population

AU - Testi, Ilaria

AU - Agrawal, Rupesh

AU - Mahajan, Sarakshi

AU - Agarwal, Aniruddha

AU - Gunasekeran, Dinesh Visva

AU - Raje, Dhananjay

AU - Aggarwal, Kanika

AU - Murthy, Somasheila I.

AU - Westcott, Mark

AU - Chee, Soon Phaik

AU - Mccluskey, Peter

AU - Ho, Su Ling

AU - Teoh, Stephen

AU - Cimino, Luca

AU - Biswas, Jyotirmay

AU - Narain, Shishir

AU - Agarwal, Manisha

AU - Mahendradas, Padmamalini

AU - Khairallah, Moncef

AU - Jones, Nicholas

AU - Tugal-Tutkun, Ilknur

AU - Babu, Kalpana

AU - Basu, Soumayava

AU - Carreño, Ester

AU - Lee, Richard

AU - Al-Dhibi, Hassan

AU - Bodaghi, Bahram

AU - Invernizzi, Alessandro

AU - Goldstein, Debra A.

AU - Herbort, Carl P.

AU - Barisani-Asenbauer, Talin

AU - González-López, Julio J.

AU - Androudi, Sofia

AU - Bansal, Reema

AU - Moharana, Bruttendu

AU - Esposti, Simona Degli

AU - Tasiopoulou, Anastasia

AU - Nadarajah, Sengal

AU - Agarwal, Mamta

AU - Abraham, Sharanaya

AU - Vala, Ruchi

AU - Singh, Ramandeep

AU - Sharma, Aman

AU - Sharma, Kusum

AU - Zierhut, Manfred

AU - Kon, Onn Min

AU - Cunningham, Emmett T.

AU - Kempen, John H.

AU - Nguyen, Quan Dong

AU - Pavesio, Carlos

AU - Gupta, Vishali

PY - 2020

Y1 - 2020

N2 - Purpose: To examine disease profile of tubercular uveitis (TBU) in Paediatric population. Methods: Among 945 patients of the retrospective multinational study by the Collaborative Ocular Tuberculosis Study (COTS)-1, 29 Paediatric patients diagnosed with TBU were analyzed. Results: Mean age of disease presentation was 12.8 (range 4–18 years), with predominance of males (n = 14/20; 70.0%) and Asian ethnicity (n = 25/29; 86.2%). Posterior uveitis (n = 14/28; 50%) was the most frequent uveitis phenotype, with choroidal involvement occurring in 64.7% (n = 11/17). Incidence of optic disc edema and macular edema was higher in children (n = 8/18; 44.4% and n = 5/18; 27.8%, respectively) than in adults (n = 160/942; 16.9% and n = 135/942; 14.3%, respectively). Comparison of optic disc edema between subgroups showed a significant difference (P =.006). All patients received oral corticosteroids, most of them with antitubercular therapy. Treatment failure developed in 4.8% (n = 1/21). Conclusions: Children have a more severe inflammatory response to the disease, and an intensive anti-inflammatory therapeutic regimen is required to achieve a positive treatment outcome.

AB - Purpose: To examine disease profile of tubercular uveitis (TBU) in Paediatric population. Methods: Among 945 patients of the retrospective multinational study by the Collaborative Ocular Tuberculosis Study (COTS)-1, 29 Paediatric patients diagnosed with TBU were analyzed. Results: Mean age of disease presentation was 12.8 (range 4–18 years), with predominance of males (n = 14/20; 70.0%) and Asian ethnicity (n = 25/29; 86.2%). Posterior uveitis (n = 14/28; 50%) was the most frequent uveitis phenotype, with choroidal involvement occurring in 64.7% (n = 11/17). Incidence of optic disc edema and macular edema was higher in children (n = 8/18; 44.4% and n = 5/18; 27.8%, respectively) than in adults (n = 160/942; 16.9% and n = 135/942; 14.3%, respectively). Comparison of optic disc edema between subgroups showed a significant difference (P =.006). All patients received oral corticosteroids, most of them with antitubercular therapy. Treatment failure developed in 4.8% (n = 1/21). Conclusions: Children have a more severe inflammatory response to the disease, and an intensive anti-inflammatory therapeutic regimen is required to achieve a positive treatment outcome.

KW - Collaborative Ocular Tuberculosis Study (COTS)

KW - Ocular tuberculosis

KW - children

KW - pediatric population

KW - tubercular uveitis

UR - http://www.scopus.com/inward/record.url?scp=85089536911&partnerID=8YFLogxK

U2 - 10.1080/09273948.2020.1781197

DO - 10.1080/09273948.2020.1781197

M3 - Article

C2 - 32804578

AN - SCOPUS:85089536911

SN - 0927-3948

VL - 28

SP - 58

EP - 64

JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

IS - sup1

ER -

The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Descriptive Review of Tubercular Uveitis in Paediatric Population

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