The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 447 Patients with Tubercular Intermediate Uveitis and Panuveitis

Rupesh Agrawal; Bjorn Kaijun Betzler; Ilaria Testi; Sarakshi Mahajan; Aniruddha Agarwal; Dinesh Visva Gunasekeran; Dhananjay Raje; Kanika Aggarwal; Somasheila I. Murthy; Mark Westcott; Soon Phaik Chee; Peter McCluskey; Su Ling Ho; Stephen Teoh; Luca Cimino; Jyotirmay Biswas; Shishir Narain; Manisha Agarwal; Padmamalini Mahendradas; Moncef Khairallah; Nicholas Jones; Ilknur Tugal-Tutkun; Kalpana Babu; Soumayava Basu; Ester Carreño; Richard Lee; Hassan Al-Dhibi; Bahram Bodaghi; Alessandro Invernizzi; Debra A. Goldstein; Talin Barisani-Asenbauer; Julio J. González-López; Sofia Androudi; Reema Bansal; Bruttendu Moharana; Simona Degli Esposti; Anastasia Tasiopoulou; Sengal Nadarajah; Mamta Agarwal; Sharanaya Abraham; Ruchi Vala; Ramandeep Singh; Aman Sharma; Kusum Sharma; Manfred Zierhut; Onn Min Kon; Emmett T. Cunningham; John H. Kempen; Quan Dong Nguyen; Carlos Pavesio; Vishali Gupta

doi:10.1080/09273948.2020.1808226

The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 447 Patients with Tubercular Intermediate Uveitis and Panuveitis

Rupesh Agrawal, Bjorn Kaijun Betzler, Ilaria Testi, Sarakshi Mahajan, Aniruddha Agarwal, Dinesh Visva Gunasekeran, Dhananjay Raje, Kanika Aggarwal, Somasheila I. Murthy, Mark Westcott, Soon Phaik Chee, Peter McCluskey, Su Ling Ho, Stephen Teoh, Luca Cimino, Jyotirmay Biswas, Shishir Narain, Manisha Agarwal, Padmamalini Mahendradas, Moncef KhairallahNicholas Jones, Ilknur Tugal-Tutkun, Kalpana Babu, Soumayava Basu, Ester Carreño, Richard Lee, Hassan Al-Dhibi, Bahram Bodaghi, Alessandro Invernizzi, Debra A. Goldstein, Talin Barisani-Asenbauer, Julio J. González-López, Sofia Androudi, Reema Bansal, Bruttendu Moharana, Simona Degli Esposti, Anastasia Tasiopoulou, Sengal Nadarajah, Mamta Agarwal, Sharanaya Abraham, Ruchi Vala, Ramandeep Singh, Aman Sharma, Kusum Sharma, Manfred Zierhut, Onn Min Kon, Emmett T. Cunningham, John H. Kempen, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta

Division of Hospital Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Purpose: Tubercular intermediate uveitis (TIU) and panuveitis (TBP) are difficult to manage because of limitations in diagnostic tools and lack of evidence-based treatment guidelines. The Collaborative Ocular Tuberculosis Study (COTS) analyzed treatment regimens and therapeutic outcomes in patients with TIU and TBP. Methods: Multicentre retrospective analysis. Results A total of 138 TIU and 309 TBP patients were included. A total of 382 subjects received antitubercular therapy (ATT) (n = 382/447; 85.4%) and 382 received corticosteroids (n = 382/447; 85.4%). Treatment failure was observed in 78 individuals (n = 78/447; 17.4%), occurring less frequently in patients receiving ATT (n = 66/382; 17.2%) compared to those who did not (n = 12/65; 18.5%). The study did not show any statistically significant therapeutic effect of ATT in patients with TIU and TBP. Conclusion Taking into account the limitations of the retrospective, non-randomized study design, resultant reliance on reported data records, and unequal size of the samples, the current study cannot provide conclusive evidence on the therapeutic benefit of ATT in TIU and TBP.

Original language	English
Pages (from-to)	27-37
Number of pages	11
Journal	Ocular Immunology and Inflammation
Volume	28
Issue number	sup1
DOIs	https://doi.org/10.1080/09273948.2020.1808226
State	Published - 2020

Keywords

Anti-tubercular therapy
collaborative ocular tuberculosis study (COTS)
ocular tuberculosis
tubercular intermediate uveitis
tubercular panuveitis
tubercular uveitis
uveitis

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10.1080/09273948.2020.1808226

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Agrawal, R., Betzler, B. K., Testi, I., Mahajan, S., Agarwal, A., Gunasekeran, D. V., Raje, D., Aggarwal, K., Murthy, S. I., Westcott, M., Chee, S. P., McCluskey, P., Ho, S. L., Teoh, S., Cimino, L., Biswas, J., Narain, S., Agarwal, M., Mahendradas, P., ... Gupta, V. (2020). The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 447 Patients with Tubercular Intermediate Uveitis and Panuveitis. Ocular Immunology and Inflammation, 28(sup1), 27-37. https://doi.org/10.1080/09273948.2020.1808226

@article{781b6822a25748059d3122f196381a83,

title = "The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 447 Patients with Tubercular Intermediate Uveitis and Panuveitis",

abstract = "Purpose: Tubercular intermediate uveitis (TIU) and panuveitis (TBP) are difficult to manage because of limitations in diagnostic tools and lack of evidence-based treatment guidelines. The Collaborative Ocular Tuberculosis Study (COTS) analyzed treatment regimens and therapeutic outcomes in patients with TIU and TBP. Methods: Multicentre retrospective analysis. Results A total of 138 TIU and 309 TBP patients were included. A total of 382 subjects received antitubercular therapy (ATT) (n = 382/447; 85.4%) and 382 received corticosteroids (n = 382/447; 85.4%). Treatment failure was observed in 78 individuals (n = 78/447; 17.4%), occurring less frequently in patients receiving ATT (n = 66/382; 17.2%) compared to those who did not (n = 12/65; 18.5%). The study did not show any statistically significant therapeutic effect of ATT in patients with TIU and TBP. Conclusion Taking into account the limitations of the retrospective, non-randomized study design, resultant reliance on reported data records, and unequal size of the samples, the current study cannot provide conclusive evidence on the therapeutic benefit of ATT in TIU and TBP.",

keywords = "Anti-tubercular therapy, collaborative ocular tuberculosis study (COTS), ocular tuberculosis, tubercular intermediate uveitis, tubercular panuveitis, tubercular uveitis, uveitis",

author = "Rupesh Agrawal and Betzler, {Bjorn Kaijun} and Ilaria Testi and Sarakshi Mahajan and Aniruddha Agarwal and Gunasekeran, {Dinesh Visva} and Dhananjay Raje and Kanika Aggarwal and Murthy, {Somasheila I.} and Mark Westcott and Chee, {Soon Phaik} and Peter McCluskey and Ho, {Su Ling} and Stephen Teoh and Luca Cimino and Jyotirmay Biswas and Shishir Narain and Manisha Agarwal and Padmamalini Mahendradas and Moncef Khairallah and Nicholas Jones and Ilknur Tugal-Tutkun and Kalpana Babu and Soumayava Basu and Ester Carre{\~n}o and Richard Lee and Hassan Al-Dhibi and Bahram Bodaghi and Alessandro Invernizzi and Goldstein, {Debra A.} and Talin Barisani-Asenbauer and Gonz{\'a}lez-L{\'o}pez, {Julio J.} and Sofia Androudi and Reema Bansal and Bruttendu Moharana and Esposti, {Simona Degli} and Anastasia Tasiopoulou and Sengal Nadarajah and Mamta Agarwal and Sharanaya Abraham and Ruchi Vala and Ramandeep Singh and Aman Sharma and Kusum Sharma and Manfred Zierhut and Kon, {Onn Min} and Cunningham, {Emmett T.} and Kempen, {John H.} and Nguyen, {Quan Dong} and Carlos Pavesio and Vishali Gupta",

note = "Publisher Copyright: {\textcopyright} 2020 Taylor & Francis Group, LLC.",

year = "2020",

doi = "10.1080/09273948.2020.1808226",

language = "English",

volume = "28",

pages = "27--37",

journal = "Ocular Immunology and Inflammation",

issn = "0927-3948",

number = "sup1",

}

Agrawal, R, Betzler, BK, Testi, I, Mahajan, S, Agarwal, A, Gunasekeran, DV, Raje, D, Aggarwal, K, Murthy, SI, Westcott, M, Chee, SP, McCluskey, P, Ho, SL, Teoh, S, Cimino, L, Biswas, J, Narain, S, Agarwal, M, Mahendradas, P, Khairallah, M, Jones, N, Tugal-Tutkun, I, Babu, K, Basu, S, Carreño, E, Lee, R, Al-Dhibi, H, Bodaghi, B, Invernizzi, A, Goldstein, DA, Barisani-Asenbauer, T, González-López, JJ, Androudi, S, Bansal, R, Moharana, B, Esposti, SD, Tasiopoulou, A, Nadarajah, S, Agarwal, M, Abraham, S, Vala, R, Singh, R, Sharma, A, Sharma, K, Zierhut, M, Kon, OM, Cunningham, ET, Kempen, JH, Nguyen, QD, Pavesio, C & Gupta, V 2020, 'The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 447 Patients with Tubercular Intermediate Uveitis and Panuveitis', Ocular Immunology and Inflammation, vol. 28, no. sup1, pp. 27-37. https://doi.org/10.1080/09273948.2020.1808226

TY - JOUR

T1 - The Collaborative Ocular Tuberculosis Study (COTS)-1

T2 - A Multinational Review of 447 Patients with Tubercular Intermediate Uveitis and Panuveitis

AU - Agrawal, Rupesh

AU - Betzler, Bjorn Kaijun

AU - Testi, Ilaria

AU - Mahajan, Sarakshi

AU - Agarwal, Aniruddha

AU - Gunasekeran, Dinesh Visva

AU - Raje, Dhananjay

AU - Aggarwal, Kanika

AU - Murthy, Somasheila I.

AU - Westcott, Mark

AU - Chee, Soon Phaik

AU - McCluskey, Peter

AU - Ho, Su Ling

AU - Teoh, Stephen

AU - Cimino, Luca

AU - Biswas, Jyotirmay

AU - Narain, Shishir

AU - Agarwal, Manisha

AU - Mahendradas, Padmamalini

AU - Khairallah, Moncef

AU - Jones, Nicholas

AU - Tugal-Tutkun, Ilknur

AU - Babu, Kalpana

AU - Basu, Soumayava

AU - Carreño, Ester

AU - Lee, Richard

AU - Al-Dhibi, Hassan

AU - Bodaghi, Bahram

AU - Invernizzi, Alessandro

AU - Goldstein, Debra A.

AU - Barisani-Asenbauer, Talin

AU - González-López, Julio J.

AU - Androudi, Sofia

AU - Bansal, Reema

AU - Moharana, Bruttendu

AU - Esposti, Simona Degli

AU - Tasiopoulou, Anastasia

AU - Nadarajah, Sengal

AU - Agarwal, Mamta

AU - Abraham, Sharanaya

AU - Vala, Ruchi

AU - Singh, Ramandeep

AU - Sharma, Aman

AU - Sharma, Kusum

AU - Zierhut, Manfred

AU - Kon, Onn Min

AU - Cunningham, Emmett T.

AU - Kempen, John H.

AU - Nguyen, Quan Dong

AU - Pavesio, Carlos

AU - Gupta, Vishali

PY - 2020

Y1 - 2020

N2 - Purpose: Tubercular intermediate uveitis (TIU) and panuveitis (TBP) are difficult to manage because of limitations in diagnostic tools and lack of evidence-based treatment guidelines. The Collaborative Ocular Tuberculosis Study (COTS) analyzed treatment regimens and therapeutic outcomes in patients with TIU and TBP. Methods: Multicentre retrospective analysis. Results A total of 138 TIU and 309 TBP patients were included. A total of 382 subjects received antitubercular therapy (ATT) (n = 382/447; 85.4%) and 382 received corticosteroids (n = 382/447; 85.4%). Treatment failure was observed in 78 individuals (n = 78/447; 17.4%), occurring less frequently in patients receiving ATT (n = 66/382; 17.2%) compared to those who did not (n = 12/65; 18.5%). The study did not show any statistically significant therapeutic effect of ATT in patients with TIU and TBP. Conclusion Taking into account the limitations of the retrospective, non-randomized study design, resultant reliance on reported data records, and unequal size of the samples, the current study cannot provide conclusive evidence on the therapeutic benefit of ATT in TIU and TBP.

AB - Purpose: Tubercular intermediate uveitis (TIU) and panuveitis (TBP) are difficult to manage because of limitations in diagnostic tools and lack of evidence-based treatment guidelines. The Collaborative Ocular Tuberculosis Study (COTS) analyzed treatment regimens and therapeutic outcomes in patients with TIU and TBP. Methods: Multicentre retrospective analysis. Results A total of 138 TIU and 309 TBP patients were included. A total of 382 subjects received antitubercular therapy (ATT) (n = 382/447; 85.4%) and 382 received corticosteroids (n = 382/447; 85.4%). Treatment failure was observed in 78 individuals (n = 78/447; 17.4%), occurring less frequently in patients receiving ATT (n = 66/382; 17.2%) compared to those who did not (n = 12/65; 18.5%). The study did not show any statistically significant therapeutic effect of ATT in patients with TIU and TBP. Conclusion Taking into account the limitations of the retrospective, non-randomized study design, resultant reliance on reported data records, and unequal size of the samples, the current study cannot provide conclusive evidence on the therapeutic benefit of ATT in TIU and TBP.

KW - Anti-tubercular therapy

KW - collaborative ocular tuberculosis study (COTS)

KW - ocular tuberculosis

KW - tubercular intermediate uveitis

KW - tubercular panuveitis

KW - tubercular uveitis

KW - uveitis

UR - http://www.scopus.com/inward/record.url?scp=85096181835&partnerID=8YFLogxK

U2 - 10.1080/09273948.2020.1808226

DO - 10.1080/09273948.2020.1808226

M3 - Article

C2 - 33200957

AN - SCOPUS:85096181835

SN - 0927-3948

VL - 28

SP - 27

EP - 37

JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

IS - sup1

ER -

The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 447 Patients with Tubercular Intermediate Uveitis and Panuveitis

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