TY - JOUR
T1 - The cognitive neuroscience of schizophrenia
AU - Barch, Deanna M.
PY - 2005
Y1 - 2005
N2 - Individuals with schizophrenia experience a range of cognitive deficits and associated dysfunctions in the neural systems that support cognitive processes. This chapter reviews the literature on disturbances in working memory, executive control, and episodic memory in schizophrenia. Advances in basic cognitive neuroscience are described to help explain the cognitive neuroscience of schizophrenia. For working memory in schizophrenia, evidence is reviewed regarding deficits in the verbal (phonological loop) and nonverbal (visual-spatial scratch pad) buffer systems as well as in the central executive function. In the domain of episodic memory, evidence is reviewed for deficits in recollection versus familiarity processes in episodic memory. Also discussed are conceptual issues and potential confounds relevant to understanding the cognitive neuroscience of schizophrenia, including the role that cognitive deficits play in the developmental course of schizophrenia, relationships to specific symptom domains, behavioral performance confounds, and medication influences on behavioral performance and brain function.
AB - Individuals with schizophrenia experience a range of cognitive deficits and associated dysfunctions in the neural systems that support cognitive processes. This chapter reviews the literature on disturbances in working memory, executive control, and episodic memory in schizophrenia. Advances in basic cognitive neuroscience are described to help explain the cognitive neuroscience of schizophrenia. For working memory in schizophrenia, evidence is reviewed regarding deficits in the verbal (phonological loop) and nonverbal (visual-spatial scratch pad) buffer systems as well as in the central executive function. In the domain of episodic memory, evidence is reviewed for deficits in recollection versus familiarity processes in episodic memory. Also discussed are conceptual issues and potential confounds relevant to understanding the cognitive neuroscience of schizophrenia, including the role that cognitive deficits play in the developmental course of schizophrenia, relationships to specific symptom domains, behavioral performance confounds, and medication influences on behavioral performance and brain function.
KW - Episodic memory
KW - Executive control
KW - Hippocampus
KW - Prefrontal cortex
KW - Working memory
UR - http://www.scopus.com/inward/record.url?scp=26444477725&partnerID=8YFLogxK
U2 - 10.1146/annurev.clinpsy.1.102803.143959
DO - 10.1146/annurev.clinpsy.1.102803.143959
M3 - Review article
C2 - 17716091
AN - SCOPUS:26444477725
SN - 1548-5943
VL - 1
SP - 321
EP - 353
JO - Annual Review of Clinical Psychology
JF - Annual Review of Clinical Psychology
ER -