TY - JOUR
T1 - The CNS Immune-Privilege Goes Down the Drain(age)
AU - Brioschi, Simone
AU - Colonna, Marco
N1 - Publisher Copyright:
© 2018
PY - 2019/1
Y1 - 2019/1
N2 - Ongoing research is revealing multiple, previously unappreciated, facets of immunity in the central nervous system, and the recent studies on the meningeal lymphatic system represent an emblematic example. In this context, a paper from Louveau and colleagues (Nat. Neurosci. 2018;21:1380–1391), which we discuss here, elucidates the importance of the meningeal lymphatics for the drainage of macromolecules and immune cells from the cerebrospinal fluid, and their delivery into the cervical lymph nodes, especially during neuroinflammatory diseases.
AB - Ongoing research is revealing multiple, previously unappreciated, facets of immunity in the central nervous system, and the recent studies on the meningeal lymphatic system represent an emblematic example. In this context, a paper from Louveau and colleagues (Nat. Neurosci. 2018;21:1380–1391), which we discuss here, elucidates the importance of the meningeal lymphatics for the drainage of macromolecules and immune cells from the cerebrospinal fluid, and their delivery into the cervical lymph nodes, especially during neuroinflammatory diseases.
KW - Brain immunity
KW - experimental autoimmune encephalomyelitis
KW - meningeal T cells
KW - meningeal lymphatic vessels
KW - multiple sclerosis
UR - http://www.scopus.com/inward/record.url?scp=85057825700&partnerID=8YFLogxK
U2 - 10.1016/j.tips.2018.11.006
DO - 10.1016/j.tips.2018.11.006
M3 - Short survey
C2 - 30528463
AN - SCOPUS:85057825700
SN - 0165-6147
VL - 40
SP - 1
EP - 3
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 1
ER -