The clinical utility of radionuclide ventriculography in cardiac transplantation

K. J. Lee, J. W. Wallis, T. R. Miller, R. M. Bolman

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

To assess ventricular function in patients who have undergone cardiac transplantation, 247 radionuclide ventriculograms were performed on 94 patients. During the first three days after transplantation, 19% demonstrated left ventricular dysfunction and 41% showed isolated right ventricular dysfunction. In 95 cases, radionuclide ventriculography was performed within 24 hr of myocardial biopsy. A reduction in left ventricular ejection fraction to <50% was significantly more common with moderate-severe rejection than with mild rejection. In six instances in which there was discordance between ventriculography and biopsy, radionuclide ventriculography proved particularly useful: three cases showed severe left ventricular dysfunction despite only mild rejection by biopsy, and three cases with ventricular dysfunction from rejection were missed by the initial biopsy. Thus, radionuclide ventriculography can provide functional data in transplant patients that is complementary to myocardial biopsies since biopsy grade is a poor predictor of left ventricular function and biopsy can miss significant rejection.

Original languageEnglish
Pages (from-to)1933-1939
Number of pages7
JournalJournal of Nuclear Medicine
Volume31
Issue number12
StatePublished - Dec 1 1990

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