The clinical manifestations of plaque rupture

Michael Berlowitz, David L. Brown

Research output: Chapter in Book/Report/Conference proceedingChapter


The acute coronary syndromes of unstable angina, acute myocardial infarction, and sudden ischemic cardiac death share a common pathophysiology: the abrupt development of ischemia caused by the obstruction of a coronary artery by thrombus formed on an acutely disrupted atherosclerotic plaque (1). Together these syndromes affect approximately 2.5 million persons and account for 600,000 or 1 in 5 deaths annually in the United States. This chapter provides an overview of the clinical manifestations of plaque rupture with its main focus on the acute coronary syndromes.

Original languageEnglish
Title of host publicationCardiovascular Plaque Rupture
PublisherCRC Press
Number of pages24
ISBN (Electronic)9780824744823
ISBN (Print)9780824702762
StatePublished - Jan 1 2002
Externally publishedYes

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    Berlowitz, M., & Brown, D. L. (2002). The clinical manifestations of plaque rupture. In Cardiovascular Plaque Rupture (pp. 191-214). CRC Press.