The Clinical Management of Clonal Hematopoiesis: Creation of a Clonal Hematopoiesis Clinic

Kelly L. Bolton, Ahmet Zehir, Ryan N. Ptashkin, Minal Patel, Dipti Gupta, Robert Sidlow, Elli Papaemmanuil, Michael F. Berger, Ross L. Levine

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

The acquisition of mutations in hematologic stem cells (clonal hematopoiesis) is common with normal aging and can be identified as an incidental finding through clinical genetic testing. Clonal hematopoiesis is associated with a heightened risk of developing hematologic neoplasms (especially myeloid) and accelerated atherosclerotic cardiovascular disease. This article discusses a multidisciplinary clinical approach to the management of patients with clonal hematopoiesis. Key areas of research needed to establish evidence-based clinical care guidelines and intervention strategies for individuals with clonal hematopoiesis are discussed.

Original languageEnglish
Pages (from-to)357-367
Number of pages11
JournalHematology/Oncology Clinics of North America
Volume34
Issue number2
DOIs
StatePublished - Apr 2020

Keywords

  • Clonal cytopenias of uncertain significance
  • Clonal hematopoiesis
  • Clonal hematopoiesis of indeterminate significance

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