The Circadian Clock, the Brain, and COVID-19: The Cases of Olfaction and the Timing of Sleep

Rachel S. Herz; Erik D. Herzog; Martha Merrow; Sara B. Noya

doi:10.1177/07487304211031206

The Circadian Clock, the Brain, and COVID-19: The Cases of Olfaction and the Timing of Sleep

Rachel S. Herz, Erik D. Herzog, Martha Merrow, Sara B. Noya

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Daily rhythms of behavior and neurophysiology are integral to the circadian clocks of all animals. Examples of circadian clock regulation in the human brain include daily rhythms in sleep-wake, cognitive function, olfactory sensitivity, and risk for ischemic stroke, all of which overlap with symptoms displayed by many COVID-19 patients. Motivated by the relatively unexplored, yet pervasive, overlap between circadian functions and COVID-19 neurological symptoms, this perspective piece uses daily variations in the sense of smell and the timing of sleep and wakefulness as illustrative examples. We propose that time-stamping clinical data and testing may expand and refine diagnosis and treatment of COVID-19.

Original language	English
Pages (from-to)	423-431
Number of pages	9
Journal	Journal of Biological Rhythms
Volume	36
Issue number	5
DOIs	https://doi.org/10.1177/07487304211031206
State	Published - Oct 2021

Keywords

COVID-19
circadian
neurological
olfaction
sleep

Access to Document

10.1177/07487304211031206

Cite this

@article{bdb1384b21764a3f8b022876e852c5b3,

title = "The Circadian Clock, the Brain, and COVID-19: The Cases of Olfaction and the Timing of Sleep",

abstract = "Daily rhythms of behavior and neurophysiology are integral to the circadian clocks of all animals. Examples of circadian clock regulation in the human brain include daily rhythms in sleep-wake, cognitive function, olfactory sensitivity, and risk for ischemic stroke, all of which overlap with symptoms displayed by many COVID-19 patients. Motivated by the relatively unexplored, yet pervasive, overlap between circadian functions and COVID-19 neurological symptoms, this perspective piece uses daily variations in the sense of smell and the timing of sleep and wakefulness as illustrative examples. We propose that time-stamping clinical data and testing may expand and refine diagnosis and treatment of COVID-19.",

keywords = "COVID-19, circadian, neurological, olfaction, sleep",

author = "Herz, {Rachel S.} and Herzog, {Erik D.} and Martha Merrow and Noya, {Sara B.}",

note = "Funding Information: We thank Prof. Kathryn Roecklein and Prof. Dr. Elizabeth Coulthard for discussions at the early stage of this work. We also acknowledge the Workshop “Chronobiology of COVID-19” (https://careconferences.org) as the coalescence point for the concepts discussed here. Publisher Copyright: {\textcopyright} 2021 The Author(s).",

year = "2021",

month = oct,

doi = "10.1177/07487304211031206",

language = "English",

volume = "36",

pages = "423--431",

journal = "Journal of Biological Rhythms",

issn = "0748-7304",

number = "5",

}

TY - JOUR

T1 - The Circadian Clock, the Brain, and COVID-19

T2 - The Cases of Olfaction and the Timing of Sleep

AU - Herz, Rachel S.

AU - Herzog, Erik D.

AU - Merrow, Martha

AU - Noya, Sara B.

N1 - Funding Information: We thank Prof. Kathryn Roecklein and Prof. Dr. Elizabeth Coulthard for discussions at the early stage of this work. We also acknowledge the Workshop “Chronobiology of COVID-19” (https://careconferences.org) as the coalescence point for the concepts discussed here. Publisher Copyright: © 2021 The Author(s).

PY - 2021/10

Y1 - 2021/10

N2 - Daily rhythms of behavior and neurophysiology are integral to the circadian clocks of all animals. Examples of circadian clock regulation in the human brain include daily rhythms in sleep-wake, cognitive function, olfactory sensitivity, and risk for ischemic stroke, all of which overlap with symptoms displayed by many COVID-19 patients. Motivated by the relatively unexplored, yet pervasive, overlap between circadian functions and COVID-19 neurological symptoms, this perspective piece uses daily variations in the sense of smell and the timing of sleep and wakefulness as illustrative examples. We propose that time-stamping clinical data and testing may expand and refine diagnosis and treatment of COVID-19.

AB - Daily rhythms of behavior and neurophysiology are integral to the circadian clocks of all animals. Examples of circadian clock regulation in the human brain include daily rhythms in sleep-wake, cognitive function, olfactory sensitivity, and risk for ischemic stroke, all of which overlap with symptoms displayed by many COVID-19 patients. Motivated by the relatively unexplored, yet pervasive, overlap between circadian functions and COVID-19 neurological symptoms, this perspective piece uses daily variations in the sense of smell and the timing of sleep and wakefulness as illustrative examples. We propose that time-stamping clinical data and testing may expand and refine diagnosis and treatment of COVID-19.

KW - COVID-19

KW - circadian

KW - neurological

KW - olfaction

KW - sleep

UR - http://www.scopus.com/inward/record.url?scp=85100853307&partnerID=8YFLogxK

U2 - 10.1177/07487304211031206

DO - 10.1177/07487304211031206

M3 - Review article

C2 - 34396817

AN - SCOPUS:85100853307

SN - 0748-7304

VL - 36

SP - 423

EP - 431

JO - Journal of Biological Rhythms

JF - Journal of Biological Rhythms

IS - 5

ER -

The Circadian Clock, the Brain, and COVID-19: The Cases of Olfaction and the Timing of Sleep

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this