The cincinnati lipid research clinic family study: Familial determinants of plasma uric acid

D. C. Rao; P. M. Laskarzewski; J. A. Morrison; P. Khoury; K. Kelly; C. J. Glueck

doi:10.1007/BF00303013

The cincinnati lipid research clinic family study: Familial determinants of plasma uric acid

D. C. Rao, P. M. Laskarzewski, J. A. Morrison, P. Khoury, K. Kelly, C. J. Glueck

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Abstract

Commingling analysis of plasma uric acid levels in a random sample of 160 nuclear families supports the hypothesis that there is a mixture of three distributions. Assuming one, two, and three components in the underlying distribution, we obtained the corresponding p-values (for power transformation) as 0.059, 1.040, and 1.643, respectively. Path analysis with p=0.059 gives genetic (h²) and cultural (c²) heritabilities as 0.256 and 0.199, without much support for intergenerational differences, assortative mating, or maternal effects. Complex segregation analysis with p=0.059 supports multifactorial inheritance, consistent with the findings of Gulbrandsen et al. (1979) and Morton (1979) in other populations. This study also fails to support a major locus hypothesis, contrary to earlier reports.

Original language	English
Pages (from-to)	257-261
Number of pages	5
Journal	Human genetics
Volume	60
Issue number	3
DOIs	https://doi.org/10.1007/BF00303013
State	Published - May 1982

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abstract = "Commingling analysis of plasma uric acid levels in a random sample of 160 nuclear families supports the hypothesis that there is a mixture of three distributions. Assuming one, two, and three components in the underlying distribution, we obtained the corresponding p-values (for power transformation) as 0.059, 1.040, and 1.643, respectively. Path analysis with p=0.059 gives genetic (h2) and cultural (c2) heritabilities as 0.256 and 0.199, without much support for intergenerational differences, assortative mating, or maternal effects. Complex segregation analysis with p=0.059 supports multifactorial inheritance, consistent with the findings of Gulbrandsen et al. (1979) and Morton (1979) in other populations. This study also fails to support a major locus hypothesis, contrary to earlier reports.",

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T2 - Familial determinants of plasma uric acid

AU - Rao, D. C.

AU - Laskarzewski, P. M.

AU - Morrison, J. A.

AU - Khoury, P.

AU - Kelly, K.

AU - Glueck, C. J.

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AB - Commingling analysis of plasma uric acid levels in a random sample of 160 nuclear families supports the hypothesis that there is a mixture of three distributions. Assuming one, two, and three components in the underlying distribution, we obtained the corresponding p-values (for power transformation) as 0.059, 1.040, and 1.643, respectively. Path analysis with p=0.059 gives genetic (h2) and cultural (c2) heritabilities as 0.256 and 0.199, without much support for intergenerational differences, assortative mating, or maternal effects. Complex segregation analysis with p=0.059 supports multifactorial inheritance, consistent with the findings of Gulbrandsen et al. (1979) and Morton (1979) in other populations. This study also fails to support a major locus hypothesis, contrary to earlier reports.

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The cincinnati lipid research clinic family study: Familial determinants of plasma uric acid

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