The chronic kidney disease-mineral bone disorder (CKD-MBD) and vascular calcification

Keith A. Hruska, Yifu Fang, Toshifumi Sugatani

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The scientific progress in the pathogenesis of the CKD-MBD and vascular calcification that has accrued in recent years will be reviewed in this monograph. The factors regulating mesenchymal cell differentiation and their role in the neointimal calcification of atherosclerosis and the vascular media calcification observed in CKD and diabetes will be discussed. Bone regulatory proteins will be discussed regarding their role in bone mineralization and their participation in vascular calcification. This will include recent studies related to fetuin-A and the discovery of new skeletal hormones involved in regulating phosphate homeostasis and sensing skeletal hydroxyapatite precipitation. Finally, the relationship between skeletal mineralization and vascular mineralization will be discussed in terms of their links, especially through serum phosphate concentrations.

Original languageEnglish
Title of host publicationIssues in Dialysis
PublisherNova Science Publishers, Inc.
Pages207-220
Number of pages14
ISBN (Print)9781624175763
StatePublished - Dec 1 2013

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