The childhood asthma management program (CAMP): Design, rationale, and methods

Childhood Asthma Management Program Research Group; Gail G. Shapiro; Thomas R. DuHamel; Timothy G. Wighton; Tamara Chinn; C. Warren Bierman; Clifton T. Furukawa; Leonard C. Altman; Frank S. Virant; Paul V. Williams; Dominick A. Minotti; Michael S. Kennedy; Jonathan W. Becker; Chris Reagan; Heather Eliassen; Dan Crawford; Babi Hammond; Grace Strodtbeck; Marian Sharpe; Scott Weiss; Dirk Greineder; Walter Torda; Martha Tata; Peter Barrant; Anthony DeFilippo; Mary Grace; Stephanie Haynes; Margaret Higham; Susan Kelleher; Jay Koslof; Nancy Madden; Dana Mandel; Agnes Martinez; Jean McAuliffe; Paola Pacella; Paula Parks; Anne Plunkett; Kay Seligsohn; June Traylor; Melissa Van Horn; Janice Ware; Carolyn Wells; Ann Whitman; Joe Reisman; Ian MacLusky; Henry Levison; Anita Hall; Yola Benedet; Jennifer Chay; Michelle Collinson; Jane Finlayson-Kulchin; Kenneth Gore; Melody Miki; Renée Sananes; N. Franklin Adkinson; Peyton Eggleston; Karen Huss; Leslie Plotnick; Margaret Pulsifer; Cynthia Rand; Barbara Wheeler; Nancy Bollers; Kimberly Hyatt; Betsy Leritz; Mildred Pessaro; Stephanie Philips; Stanley Szefler; Harold S. Nelson; D. Sundström; Bruce Bender; Kristin Brelsford; Melanie Gleason; Joseph Hassell; Caroline Hendrickson; Charles G. Irvin; Tara Junk; Andrew Liu; Joseph Spahn; Michael P. White; Jeryl Feeley; Jessyca Bridges; Jody Ciacco; Michael Eltz; Michael Flynn; Marcia Hefner; Daniel Hettleman; Jeffrey Jacobs; Alan Kamada; Sai Nimmagadda; Kendra Sandoval; Jessica Sheridan; Trella Washington; Eric Willcutt; Robert Zeiger; Anthony Horner; Noah Friedman; Al Jalowayski; Alan Lincoln; Michael H. Mellon; Michael Schatz; Kathleen Harden; Linda L. Galbreath; Ellen Hanson; Elaine M. Jenson; Shirley King; Brian Lopez; Michaela Magiari; Catherine A. Nelle; Senia Pizzo; Eva Rodriquez; James G. Easton; Kathleen Mostafa; Avraham Moscona; Karen Sandoval; Bennie McWilliams; Robert Annett; H. William Kelly; Mary Spicher; Diane Becker; Selda Bereket; Marisa Braun; Shannon Bush; David Hunt; Margaret Moreshead; Barbara Ortega; Robert C. Strunk; Gordon R. Bloomberg; James M. Corry; Thomas F. Smith; Ellen Albers; Bernadette Davantes; Gregg Belle; Marisa Dolinsky; Edwin B. Fisher; Stephen J. Gaioni; Emily Glynn; Cathy Herman; Debra Kemp; Claire Lawhon; Sharon Meltzer; Cynthia Moseid; Tina Oliver-Welker; Denise Rodgers; Carl Turner; Deborah K. White; Mary Caesar; Diana S. Richardson; Elizabeth Ryan; Susan C. Sylvia; Reuben Cherniack; James Tonascia; Curtis Meinert; Debra Amend-Libercci; Patricia Belt; Karen Collins; Betty Collison; Christopher Dawson; John Dodge; Michele Donithan; Dawn Easton; Vera Edmonds; Cathleen Ewing; Judith Harle; Robert Huffman; Kung Yee Liang; Jill Meinert; Deborah Nowakowski; Rosetta Owens; Michael Smith; Alice Sternberg; Mark Van Natta; Robert Wise; Robert Rice; Bob Hughes; Tom Lynch; Sarma Vadlamani; Robert G. Hamilton; Carol Schatz; Jack Wisenauer; Ronald J. Harbeck; Rhonda Emerick; Brian Watson; Cindi Culkin; Sarah Oliver; Colleen Lum Lung; Ann Mullen; Virginia Taggart; Pamela Randall; Paul Albert; Suzanne Hurd; James Kiley; Margaret Wu; Sydney Parker; William Letvenko; William Repko; Rolland Poust; David Herold; Dennis Elbert; Howard Eigen; Michelle Cloutier; John Connett

doi:10.1016/S0197-2456(98)00044-0

The childhood asthma management program (CAMP): Design, rationale, and methods

Childhood Asthma Management Program Research Group
, Gail G. Shapiro
, Thomas R. DuHamel
, Timothy G. Wighton
, Tamara Chinn
, C. Warren Bierman
, Clifton T. Furukawa
, Leonard C. Altman
, Frank S. Virant
, Paul V. Williams
, Dominick A. Minotti
, Michael S. Kennedy
, Jonathan W. Becker
, Chris Reagan
, Heather Eliassen
, Dan Crawford
, Babi Hammond
, Grace Strodtbeck
, Marian Sharpe
, Scott Weiss

Dirk Greineder, Walter Torda, Martha Tata, Peter Barrant, Anthony DeFilippo, Mary Grace, Stephanie Haynes, Margaret Higham, Susan Kelleher, Jay Koslof, Nancy Madden, Dana Mandel, Agnes Martinez, Jean McAuliffe, Paola Pacella, Paula Parks, Anne Plunkett, Kay Seligsohn, June Traylor, Melissa Van Horn, Janice Ware, Carolyn Wells, Ann Whitman, Joe Reisman, Ian MacLusky, Henry Levison, Anita Hall, Yola Benedet, Jennifer Chay, Michelle Collinson, Jane Finlayson-Kulchin, Kenneth Gore, Melody Miki, Renée Sananes, N. Franklin Adkinson, Peyton Eggleston, Karen Huss, Leslie Plotnick, Margaret Pulsifer, Cynthia Rand, Barbara Wheeler, Nancy Bollers, Kimberly Hyatt, Betsy Leritz, Mildred Pessaro, Stephanie Philips, Stanley Szefler, Harold S. Nelson, D. Sundström, Bruce Bender, Kristin Brelsford, Melanie Gleason, Joseph Hassell, Caroline Hendrickson, Charles G. Irvin, Tara Junk, Andrew Liu, Joseph Spahn, Michael P. White, Jeryl Feeley, Jessyca Bridges, Jody Ciacco, Michael Eltz, Michael Flynn, Marcia Hefner, Daniel Hettleman, Jeffrey Jacobs, Alan Kamada, Sai Nimmagadda, Kendra Sandoval, Jessica Sheridan, Trella Washington, Eric Willcutt, Robert Zeiger, Anthony Horner, Noah Friedman, Al Jalowayski, Alan Lincoln, Michael H. Mellon, Michael Schatz, Kathleen Harden, Linda L. Galbreath, Ellen Hanson, Elaine M. Jenson, Shirley King, Brian Lopez, Michaela Magiari, Catherine A. Nelle, Senia Pizzo, Eva Rodriquez, James G. Easton, Kathleen Mostafa, Avraham Moscona, Karen Sandoval, Bennie McWilliams, Robert Annett, H. William Kelly, Mary Spicher, Diane Becker, Selda Bereket, Marisa Braun, Shannon Bush, David Hunt, Margaret Moreshead, Barbara Ortega, Robert C. Strunk, Gordon R. Bloomberg, James M. Corry, Thomas F. Smith, Ellen Albers, Bernadette Davantes, Gregg Belle, Marisa Dolinsky, Edwin B. Fisher, Stephen J. Gaioni, Emily Glynn, Cathy Herman, Debra Kemp, Claire Lawhon, Sharon Meltzer, Cynthia Moseid, Tina Oliver-Welker, Denise Rodgers, Carl Turner, Deborah K. White, Mary Caesar, Diana S. Richardson, Elizabeth Ryan, Susan C. Sylvia, Reuben Cherniack, James Tonascia, Curtis Meinert, Debra Amend-Libercci, Patricia Belt, Karen Collins, Betty Collison, Christopher Dawson, John Dodge, Michele Donithan, Dawn Easton, Vera Edmonds, Cathleen Ewing, Judith Harle, Robert Huffman, Kung Yee Liang, Jill Meinert, Deborah Nowakowski, Rosetta Owens, Michael Smith, Alice Sternberg, Mark Van Natta, Robert Wise, Robert Rice, Bob Hughes, Tom Lynch, Sarma Vadlamani, Robert G. Hamilton, Carol Schatz, Jack Wisenauer, Ronald J. Harbeck, Rhonda Emerick, Brian Watson, Cindi Culkin, Sarah Oliver, Colleen Lum Lung, Ann Mullen, Virginia Taggart, Pamela Randall, Paul Albert, Suzanne Hurd, James Kiley, Margaret Wu, Sydney Parker, William Letvenko, William Repko, Rolland Poust, David Herold, Dennis Elbert, Howard Eigen, Michelle Cloutier, John Connett

Division of General Medicine & Geriatrics

Research output: Contribution to journal › Article › peer-review

329 Scopus citations

Abstract

The Childhood Asthma Management Program (CAMP) is a multicenter, randomized, double-masked clinical trial designed to determine the long-term effects of three inhaled treatments for mild to moderate childhood asthma: budesonide (a glucocorticoid used daily) and albuterol (a short-acting β-agonist bronchodilator used as needed); nedocromil (a nonsteroid anti-inflammatory agent used daily) and albuterol; and placebo and albuterol. One thousand forty-one children (32% from ethnic minority groups), aged 5 to 12 years at screening, are currently participating. The primary outcome measure is lung growth as indicated by postbronchodilator forced expiratory volume in 1 second (FEV₁) percent of predicted, observed over 5- to 6-year period. The trial also assesses differences between treatment groups with respect to airway responsiveness, morbidity, physical growth and development, and psychological growth and development. This report describes the design of the trial, the rationale for the design choices made, and the methods used to carry out the trial.

Original language	English
Pages (from-to)	91-120
Number of pages	30
Journal	Controlled clinical trials
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/S0197-2456(98)00044-0
State	Published - Feb 1999

Keywords

Albuterol
Allergens
Anti-inflammatory agents
Atopy
Bronchial provocation test
Bronchodilator agents
Budesonide
Childhood asthma
Clinical trials
Environmental exposure
Glucocorticoids
Growth
Inhaled bronchodilator
Nedocromil
Psychological test
Spirometry

Access to Document

10.1016/S0197-2456(98)00044-0

Cite this

Childhood Asthma Management Program Research Group, Shapiro, G. G., DuHamel, T. R., Wighton, T. G., Chinn, T., Bierman, C. W., Furukawa, C. T., Altman, L. C., Virant, F. S., Williams, P. V., Minotti, D. A., Kennedy, M. S., Becker, J. W., Reagan, C., Eliassen, H., Crawford, D., Hammond, B., Strodtbeck, G., Sharpe, M., ... Connett, J. (1999). The childhood asthma management program (CAMP): Design, rationale, and methods. Controlled clinical trials, 20(1), 91-120. https://doi.org/10.1016/S0197-2456(98)00044-0

@article{74ea60ef9c0d47009b1b1cc316c15f61,

title = "The childhood asthma management program (CAMP): Design, rationale, and methods",

abstract = "The Childhood Asthma Management Program (CAMP) is a multicenter, randomized, double-masked clinical trial designed to determine the long-term effects of three inhaled treatments for mild to moderate childhood asthma: budesonide (a glucocorticoid used daily) and albuterol (a short-acting β-agonist bronchodilator used as needed); nedocromil (a nonsteroid anti-inflammatory agent used daily) and albuterol; and placebo and albuterol. One thousand forty-one children (32\% from ethnic minority groups), aged 5 to 12 years at screening, are currently participating. The primary outcome measure is lung growth as indicated by postbronchodilator forced expiratory volume in 1 second (FEV1) percent of predicted, observed over 5- to 6-year period. The trial also assesses differences between treatment groups with respect to airway responsiveness, morbidity, physical growth and development, and psychological growth and development. This report describes the design of the trial, the rationale for the design choices made, and the methods used to carry out the trial.",

keywords = "Albuterol, Allergens, Anti-inflammatory agents, Atopy, Bronchial provocation test, Bronchodilator agents, Budesonide, Childhood asthma, Clinical trials, Environmental exposure, Glucocorticoids, Growth, Inhaled bronchodilator, Nedocromil, Psychological test, Spirometry",

author = "\{Childhood Asthma Management Program Research Group\} and Shapiro, \{Gail G.\} and DuHamel, \{Thomas R.\} and Wighton, \{Timothy G.\} and Tamara Chinn and Bierman, \{C. Warren\} and Furukawa, \{Clifton T.\} and Altman, \{Leonard C.\} and Virant, \{Frank S.\} and Williams, \{Paul V.\} and Minotti, \{Dominick A.\} and Kennedy, \{Michael S.\} and Becker, \{Jonathan W.\} and Chris Reagan and Heather Eliassen and Dan Crawford and Babi Hammond and Grace Strodtbeck and Marian Sharpe and Scott Weiss and Dirk Greineder and Walter Torda and Martha Tata and Peter Barrant and Anthony DeFilippo and Mary Grace and Stephanie Haynes and Margaret Higham and Susan Kelleher and Jay Koslof and Nancy Madden and Dana Mandel and Agnes Martinez and Jean McAuliffe and Paola Pacella and Paula Parks and Anne Plunkett and Kay Seligsohn and June Traylor and \{Van Horn\}, Melissa and Janice Ware and Carolyn Wells and Ann Whitman and Joe Reisman and Ian MacLusky and Henry Levison and Anita Hall and Yola Benedet and Jennifer Chay and Michelle Collinson and Jane Finlayson-Kulchin and Kenneth Gore and Melody Miki and Ren{\'e}e Sananes and Adkinson, \{N. Franklin\} and Peyton Eggleston and Karen Huss and Leslie Plotnick and Margaret Pulsifer and Cynthia Rand and Barbara Wheeler and Nancy Bollers and Kimberly Hyatt and Betsy Leritz and Mildred Pessaro and Stephanie Philips and Stanley Szefler and Nelson, \{Harold S.\} and D. Sundstr{\"o}m and Bruce Bender and Kristin Brelsford and Melanie Gleason and Joseph Hassell and Caroline Hendrickson and Irvin, \{Charles G.\} and Tara Junk and Andrew Liu and Joseph Spahn and White, \{Michael P.\} and Jeryl Feeley and Jessyca Bridges and Jody Ciacco and Michael Eltz and Michael Flynn and Marcia Hefner and Daniel Hettleman and Jeffrey Jacobs and Alan Kamada and Sai Nimmagadda and Kendra Sandoval and Jessica Sheridan and Trella Washington and Eric Willcutt and Robert Zeiger and Anthony Horner and Noah Friedman and Al Jalowayski and Alan Lincoln and Mellon, \{Michael H.\} and Michael Schatz and Kathleen Harden and Galbreath, \{Linda L.\} and Ellen Hanson and Jenson, \{Elaine M.\} and Shirley King and Brian Lopez and Michaela Magiari and Nelle, \{Catherine A.\} and Senia Pizzo and Eva Rodriquez and Easton, \{James G.\} and Kathleen Mostafa and Avraham Moscona and Karen Sandoval and Bennie McWilliams and Robert Annett and Kelly, \{H. William\} and Mary Spicher and Diane Becker and Selda Bereket and Marisa Braun and Shannon Bush and David Hunt and Margaret Moreshead and Barbara Ortega and Strunk, \{Robert C.\} and Bloomberg, \{Gordon R.\} and Corry, \{James M.\} and Smith, \{Thomas F.\} and Ellen Albers and Bernadette Davantes and Gregg Belle and Marisa Dolinsky and Fisher, \{Edwin B.\} and Gaioni, \{Stephen J.\} and Emily Glynn and Cathy Herman and Debra Kemp and Claire Lawhon and Sharon Meltzer and Cynthia Moseid and Tina Oliver-Welker and Denise Rodgers and Carl Turner and White, \{Deborah K.\} and Mary Caesar and Richardson, \{Diana S.\} and Elizabeth Ryan and Sylvia, \{Susan C.\} and Reuben Cherniack and James Tonascia and Curtis Meinert and Debra Amend-Libercci and Patricia Belt and Karen Collins and Betty Collison and Christopher Dawson and John Dodge and Michele Donithan and Dawn Easton and Vera Edmonds and Cathleen Ewing and Judith Harle and Robert Huffman and Liang, \{Kung Yee\} and Jill Meinert and Deborah Nowakowski and Rosetta Owens and Michael Smith and Alice Sternberg and \{Van Natta\}, Mark and Robert Wise and Robert Rice and Bob Hughes and Tom Lynch and Sarma Vadlamani and Hamilton, \{Robert G.\} and Carol Schatz and Jack Wisenauer and Harbeck, \{Ronald J.\} and Rhonda Emerick and Brian Watson and Cindi Culkin and Sarah Oliver and Lung, \{Colleen Lum\} and Ann Mullen and Virginia Taggart and Pamela Randall and Paul Albert and Suzanne Hurd and James Kiley and Margaret Wu and Sydney Parker and William Letvenko and William Repko and Rolland Poust and David Herold and Dennis Elbert and Howard Eigen and Michelle Cloutier and John Connett",

note = "Publisher Copyright: {\textcopyright} Elsevier Science Inc. 1999.",

year = "1999",

month = feb,

doi = "10.1016/S0197-2456(98)00044-0",

language = "English",

volume = "20",

pages = "91--120",

journal = "Controlled clinical trials",

issn = "0197-2456",

number = "1",

}

Childhood Asthma Management Program Research Group, Shapiro, GG, DuHamel, TR, Wighton, TG, Chinn, T, Bierman, CW, Furukawa, CT, Altman, LC, Virant, FS, Williams, PV, Minotti, DA, Kennedy, MS, Becker, JW, Reagan, C, Eliassen, H, Crawford, D, Hammond, B, Strodtbeck, G, Sharpe, M, Weiss, S, Greineder, D, Torda, W, Tata, M, Barrant, P, DeFilippo, A, Grace, M, Haynes, S, Higham, M, Kelleher, S, Koslof, J, Madden, N, Mandel, D, Martinez, A, McAuliffe, J, Pacella, P, Parks, P, Plunkett, A, Seligsohn, K, Traylor, J, Van Horn, M, Ware, J, Wells, C, Whitman, A, Reisman, J, MacLusky, I, Levison, H, Hall, A, Benedet, Y, Chay, J, Collinson, M, Finlayson-Kulchin, J, Gore, K, Miki, M, Sananes, R, Adkinson, NF, Eggleston, P, Huss, K, Plotnick, L, Pulsifer, M, Rand, C, Wheeler, B, Bollers, N, Hyatt, K, Leritz, B, Pessaro, M, Philips, S, Szefler, S, Nelson, HS, Sundström, D, Bender, B, Brelsford, K, Gleason, M, Hassell, J, Hendrickson, C, Irvin, CG, Junk, T, Liu, A, Spahn, J, White, MP, Feeley, J, Bridges, J, Ciacco, J, Eltz, M, Flynn, M, Hefner, M, Hettleman, D, Jacobs, J, Kamada, A, Nimmagadda, S, Sandoval, K, Sheridan, J, Washington, T, Willcutt, E, Zeiger, R, Horner, A, Friedman, N, Jalowayski, A, Lincoln, A, Mellon, MH, Schatz, M, Harden, K, Galbreath, LL, Hanson, E, Jenson, EM, King, S, Lopez, B, Magiari, M, Nelle, CA, Pizzo, S, Rodriquez, E, Easton, JG, Mostafa, K, Moscona, A, Sandoval, K, McWilliams, B, Annett, R, Kelly, HW, Spicher, M, Becker, D, Bereket, S, Braun, M, Bush, S, Hunt, D, Moreshead, M, Ortega, B, Strunk, RC, Bloomberg, GR, Corry, JM, Smith, TF, Albers, E, Davantes, B, Belle, G, Dolinsky, M, Fisher, EB, Gaioni, SJ, Glynn, E, Herman, C, Kemp, D, Lawhon, C, Meltzer, S, Moseid, C, Oliver-Welker, T, Rodgers, D, Turner, C, White, DK, Caesar, M, Richardson, DS, Ryan, E, Sylvia, SC, Cherniack, R, Tonascia, J, Meinert, C, Amend-Libercci, D, Belt, P, Collins, K, Collison, B, Dawson, C, Dodge, J, Donithan, M, Easton, D, Edmonds, V, Ewing, C, Harle, J, Huffman, R, Liang, KY, Meinert, J, Nowakowski, D, Owens, R, Smith, M, Sternberg, A, Van Natta, M, Wise, R, Rice, R, Hughes, B, Lynch, T, Vadlamani, S, Hamilton, RG, Schatz, C, Wisenauer, J, Harbeck, RJ, Emerick, R, Watson, B, Culkin, C, Oliver, S, Lung, CL, Mullen, A, Taggart, V, Randall, P, Albert, P, Hurd, S, Kiley, J, Wu, M, Parker, S, Letvenko, W, Repko, W, Poust, R, Herold, D, Elbert, D, Eigen, H, Cloutier, M & Connett, J 1999, 'The childhood asthma management program (CAMP): Design, rationale, and methods', Controlled clinical trials, vol. 20, no. 1, pp. 91-120. https://doi.org/10.1016/S0197-2456(98)00044-0

TY - JOUR

T1 - The childhood asthma management program (CAMP)

T2 - Design, rationale, and methods

AU - Childhood Asthma Management Program Research Group

AU - Shapiro, Gail G.

AU - DuHamel, Thomas R.

AU - Wighton, Timothy G.

AU - Chinn, Tamara

AU - Bierman, C. Warren

AU - Furukawa, Clifton T.

AU - Altman, Leonard C.

AU - Virant, Frank S.

AU - Williams, Paul V.

AU - Minotti, Dominick A.

AU - Kennedy, Michael S.

AU - Becker, Jonathan W.

AU - Reagan, Chris

AU - Eliassen, Heather

AU - Crawford, Dan

AU - Hammond, Babi

AU - Strodtbeck, Grace

AU - Sharpe, Marian

AU - Weiss, Scott

AU - Greineder, Dirk

AU - Torda, Walter

AU - Tata, Martha

AU - Barrant, Peter

AU - DeFilippo, Anthony

AU - Grace, Mary

AU - Haynes, Stephanie

AU - Higham, Margaret

AU - Kelleher, Susan

AU - Koslof, Jay

AU - Madden, Nancy

AU - Mandel, Dana

AU - Martinez, Agnes

AU - McAuliffe, Jean

AU - Pacella, Paola

AU - Parks, Paula

AU - Plunkett, Anne

AU - Seligsohn, Kay

AU - Traylor, June

AU - Van Horn, Melissa

AU - Ware, Janice

AU - Wells, Carolyn

AU - Whitman, Ann

AU - Reisman, Joe

AU - MacLusky, Ian

AU - Levison, Henry

AU - Hall, Anita

AU - Benedet, Yola

AU - Chay, Jennifer

AU - Collinson, Michelle

AU - Finlayson-Kulchin, Jane

AU - Gore, Kenneth

AU - Miki, Melody

AU - Sananes, Renée

AU - Adkinson, N. Franklin

AU - Eggleston, Peyton

AU - Huss, Karen

AU - Plotnick, Leslie

AU - Pulsifer, Margaret

AU - Rand, Cynthia

AU - Wheeler, Barbara

AU - Bollers, Nancy

AU - Hyatt, Kimberly

AU - Leritz, Betsy

AU - Pessaro, Mildred

AU - Philips, Stephanie

AU - Szefler, Stanley

AU - Nelson, Harold S.

AU - Sundström, D.

AU - Bender, Bruce

AU - Brelsford, Kristin

AU - Gleason, Melanie

AU - Hassell, Joseph

AU - Hendrickson, Caroline

AU - Irvin, Charles G.

AU - Junk, Tara

AU - Liu, Andrew

AU - Spahn, Joseph

AU - White, Michael P.

AU - Feeley, Jeryl

AU - Bridges, Jessyca

AU - Ciacco, Jody

AU - Eltz, Michael

AU - Flynn, Michael

AU - Hefner, Marcia

AU - Hettleman, Daniel

AU - Jacobs, Jeffrey

AU - Kamada, Alan

AU - Nimmagadda, Sai

AU - Sandoval, Kendra

AU - Sheridan, Jessica

AU - Washington, Trella

AU - Willcutt, Eric

AU - Zeiger, Robert

AU - Horner, Anthony

AU - Friedman, Noah

AU - Jalowayski, Al

AU - Lincoln, Alan

AU - Mellon, Michael H.

AU - Schatz, Michael

AU - Harden, Kathleen

AU - Galbreath, Linda L.

AU - Hanson, Ellen

AU - Jenson, Elaine M.

AU - King, Shirley

AU - Lopez, Brian

AU - Magiari, Michaela

AU - Nelle, Catherine A.

AU - Pizzo, Senia

AU - Rodriquez, Eva

AU - Easton, James G.

AU - Mostafa, Kathleen

AU - Moscona, Avraham

AU - Sandoval, Karen

AU - McWilliams, Bennie

AU - Annett, Robert

AU - Kelly, H. William

AU - Spicher, Mary

AU - Becker, Diane

AU - Bereket, Selda

AU - Braun, Marisa

AU - Bush, Shannon

AU - Hunt, David

AU - Moreshead, Margaret

AU - Ortega, Barbara

AU - Strunk, Robert C.

AU - Bloomberg, Gordon R.

AU - Corry, James M.

AU - Smith, Thomas F.

AU - Albers, Ellen

AU - Davantes, Bernadette

AU - Belle, Gregg

AU - Dolinsky, Marisa

AU - Fisher, Edwin B.

AU - Gaioni, Stephen J.

AU - Glynn, Emily

AU - Herman, Cathy

AU - Kemp, Debra

AU - Lawhon, Claire

AU - Meltzer, Sharon

AU - Moseid, Cynthia

AU - Oliver-Welker, Tina

AU - Rodgers, Denise

AU - Turner, Carl

AU - White, Deborah K.

AU - Caesar, Mary

AU - Richardson, Diana S.

AU - Ryan, Elizabeth

AU - Sylvia, Susan C.

AU - Cherniack, Reuben

AU - Tonascia, James

AU - Meinert, Curtis

AU - Amend-Libercci, Debra

AU - Belt, Patricia

AU - Collins, Karen

AU - Collison, Betty

AU - Dawson, Christopher

AU - Dodge, John

AU - Donithan, Michele

AU - Easton, Dawn

AU - Edmonds, Vera

AU - Ewing, Cathleen

AU - Harle, Judith

AU - Huffman, Robert

AU - Liang, Kung Yee

AU - Meinert, Jill

AU - Nowakowski, Deborah

AU - Owens, Rosetta

AU - Smith, Michael

AU - Sternberg, Alice

AU - Van Natta, Mark

AU - Wise, Robert

AU - Rice, Robert

AU - Hughes, Bob

AU - Lynch, Tom

AU - Vadlamani, Sarma

AU - Hamilton, Robert G.

AU - Schatz, Carol

AU - Wisenauer, Jack

AU - Harbeck, Ronald J.

AU - Emerick, Rhonda

AU - Watson, Brian

AU - Culkin, Cindi

AU - Oliver, Sarah

AU - Lung, Colleen Lum

AU - Mullen, Ann

AU - Taggart, Virginia

AU - Randall, Pamela

AU - Albert, Paul

AU - Hurd, Suzanne

AU - Kiley, James

AU - Wu, Margaret

AU - Parker, Sydney

AU - Letvenko, William

AU - Repko, William

AU - Poust, Rolland

AU - Herold, David

AU - Elbert, Dennis

AU - Eigen, Howard

AU - Cloutier, Michelle

AU - Connett, John

PY - 1999/2

Y1 - 1999/2

N2 - The Childhood Asthma Management Program (CAMP) is a multicenter, randomized, double-masked clinical trial designed to determine the long-term effects of three inhaled treatments for mild to moderate childhood asthma: budesonide (a glucocorticoid used daily) and albuterol (a short-acting β-agonist bronchodilator used as needed); nedocromil (a nonsteroid anti-inflammatory agent used daily) and albuterol; and placebo and albuterol. One thousand forty-one children (32% from ethnic minority groups), aged 5 to 12 years at screening, are currently participating. The primary outcome measure is lung growth as indicated by postbronchodilator forced expiratory volume in 1 second (FEV1) percent of predicted, observed over 5- to 6-year period. The trial also assesses differences between treatment groups with respect to airway responsiveness, morbidity, physical growth and development, and psychological growth and development. This report describes the design of the trial, the rationale for the design choices made, and the methods used to carry out the trial.

AB - The Childhood Asthma Management Program (CAMP) is a multicenter, randomized, double-masked clinical trial designed to determine the long-term effects of three inhaled treatments for mild to moderate childhood asthma: budesonide (a glucocorticoid used daily) and albuterol (a short-acting β-agonist bronchodilator used as needed); nedocromil (a nonsteroid anti-inflammatory agent used daily) and albuterol; and placebo and albuterol. One thousand forty-one children (32% from ethnic minority groups), aged 5 to 12 years at screening, are currently participating. The primary outcome measure is lung growth as indicated by postbronchodilator forced expiratory volume in 1 second (FEV1) percent of predicted, observed over 5- to 6-year period. The trial also assesses differences between treatment groups with respect to airway responsiveness, morbidity, physical growth and development, and psychological growth and development. This report describes the design of the trial, the rationale for the design choices made, and the methods used to carry out the trial.

KW - Albuterol

KW - Allergens

KW - Anti-inflammatory agents

KW - Atopy

KW - Bronchial provocation test

KW - Bronchodilator agents

KW - Budesonide

KW - Childhood asthma

KW - Clinical trials

KW - Environmental exposure

KW - Glucocorticoids

KW - Growth

KW - Inhaled bronchodilator

KW - Nedocromil

KW - Psychological test

KW - Spirometry

UR - https://www.scopus.com/pages/publications/0033012176

U2 - 10.1016/S0197-2456(98)00044-0

DO - 10.1016/S0197-2456(98)00044-0

M3 - Article

C2 - 10027502

AN - SCOPUS:0033012176

SN - 0197-2456

VL - 20

SP - 91

EP - 120

JO - Controlled clinical trials

JF - Controlled clinical trials

IS - 1

ER -

The childhood asthma management program (CAMP): Design, rationale, and methods

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