The chaperone/usher pathway: A major terminal branch of the general secretory pathway

David G. Thanassi, Evan T. Saulino, Scott J. Hultgren

Research output: Contribution to journalArticle

148 Scopus citations

Abstract

Gram-negative bacteria assemble a variety of adhesive organelles on their surface, including the thread-like structures known as pili. Recent studies on pilus assembly by the chaperone/usher pathway have revealed new insights into the mechanisms of pilus subunit export into the periplasm and targeting to the outer membrane. Signaling events controlling pilus biogenesis have begun to emerge and investigations of the usher have yielded insights into pilus translocation across the outer membrane.

Original languageEnglish
Pages (from-to)223-231
Number of pages9
JournalCurrent Opinion in Microbiology
Volume1
Issue number2
DOIs
StatePublished - Apr 1998

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