The changing landscape of ischaemic brain injury mechanisms

Jin Moo Lee; Gregory J. Zipfel; Dennis W. Choi

doi:10.1038/399a007

The changing landscape of ischaemic brain injury mechanisms

Jin Moo Lee, Gregory J. Zipfel, Dennis W. Choi

Research output: Contribution to journal › Review article › peer-review

1018 Scopus citations

Abstract

Thrombolysis has become established as an acute treatment for human stroke. But despite multiple clinical trials, neuroprotective strategies have yet to be proved effective in humans. Here we discuss intrinsic tissue mechanisms of ischaemic brain injury, and present a perspective that broadening of therapeutic targeting beyond excitotoxicity and neuronal calcium overload will be desirable for developing the most effective neuroprotective therapies.

Original language	English
Pages (from-to)	A7-A14
Journal	Nature
Volume	399
Issue number	SUPPL.
DOIs	https://doi.org/10.1038/399a007
State	Published - Jun 24 1999

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title = "The changing landscape of ischaemic brain injury mechanisms",

abstract = "Thrombolysis has become established as an acute treatment for human stroke. But despite multiple clinical trials, neuroprotective strategies have yet to be proved effective in humans. Here we discuss intrinsic tissue mechanisms of ischaemic brain injury, and present a perspective that broadening of therapeutic targeting beyond excitotoxicity and neuronal calcium overload will be desirable for developing the most effective neuroprotective therapies.",

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AU - Zipfel, Gregory J.

AU - Choi, Dennis W.

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N2 - Thrombolysis has become established as an acute treatment for human stroke. But despite multiple clinical trials, neuroprotective strategies have yet to be proved effective in humans. Here we discuss intrinsic tissue mechanisms of ischaemic brain injury, and present a perspective that broadening of therapeutic targeting beyond excitotoxicity and neuronal calcium overload will be desirable for developing the most effective neuroprotective therapies.

AB - Thrombolysis has become established as an acute treatment for human stroke. But despite multiple clinical trials, neuroprotective strategies have yet to be proved effective in humans. Here we discuss intrinsic tissue mechanisms of ischaemic brain injury, and present a perspective that broadening of therapeutic targeting beyond excitotoxicity and neuronal calcium overload will be desirable for developing the most effective neuroprotective therapies.

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DO - 10.1038/399a007

M3 - Review article

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AN - SCOPUS:0033600277

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VL - 399

SP - A7-A14

JO - Nature

JF - Nature

IS - SUPPL.

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The changing landscape of ischaemic brain injury mechanisms

Abstract

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