The CERAD experience, part VIII: Neuroimagingneuropathology correlates of temporal lobe changes in Alzheimer's disease

P. C. Davis, M. Gearing, L. Gray, S. S. Mirra, J. C. Morris, S. D. Edland, T. Lin, A. Heyman

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

We compared premortem neuroimaging findings with neuropathologic evidence of temporal lobe atrophy in 20 patients with Alzheimer's disease (AD) confirmed by autopsy. There were significant correlations between temporal horn enlargement observed by neuroimaging and hippocampal atrophy at autopsy, and between the overall cerebral atrophy severity on neuroimaging and scores on the Mini-Mental State Examination. This report confirms previous studies correlating temporal lobe atrophy on neuroimaging with a clinical diagnosis of AD, although more precise neuroimaging techniques are needed for use in multicenter studies of AD.

Original languageEnglish
Pages (from-to)178-179
Number of pages2
JournalNeurology
Volume45
Issue number1
DOIs
StatePublished - Jan 1995

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