The cellular localization of the two brain specific proteins, S-100 and 14-3-2

T. J. Cicero, W. M. Cowan, B. W. Moore, V. Suntzeff

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Abstract

An attempt has been made to localize, at a cellular level, the two brain specific proteins, S-100 and 14-3-2, by determining their relative concentrations in thalamic nuclei undergoing retrograde cell degeneration after appropriate lesions of the cerebral cortex. As the neuronal degeneration progresses the concentration of the 14-3-2 protein declines so that 6 weeks postoperatively it is only approximately 40% of its control level. On the other hand, there is a slight, but statistically significant, increase in the level of the S-100 protein between the 1st and 4th postoperative weeks which appears to be correlated with the early gliosis in the affected nuclei. On this basis it is suggested that 14-3-2 is primarily a neuronal protein and that the S-100 protein is largely, if not exclusively, confined to glial cells.

Original languageEnglish
Pages (from-to)25-34
Number of pages10
JournalBrain Research
Volume18
Issue number1
DOIs
StatePublished - Feb 17 1970

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