TY - JOUR
T1 - The cellular localization of the two brain specific proteins, S-100 and 14-3-2
AU - Cicero, T. J.
AU - Cowan, W. M.
AU - Moore, B. W.
AU - Suntzeff, V.
N1 - Funding Information:
We wish to acknowledge the technical assistance of Mrs. Babette Labovitz and Mrs. Evelyn White. Supported by U.S. Public Health Service Grants NB-05270, NB-08647 and NB-07874, and by National Multiple Sclerosis Society Grant 513A. T.J.C. is a postdoctoral fellow supported by Mental Health Training Grant MH-07081; B.W.M. a recipient of Public Health Service Career Development Award 5-K3-GM-15543.
PY - 1970/2/17
Y1 - 1970/2/17
N2 - An attempt has been made to localize, at a cellular level, the two brain specific proteins, S-100 and 14-3-2, by determining their relative concentrations in thalamic nuclei undergoing retrograde cell degeneration after appropriate lesions of the cerebral cortex. As the neuronal degeneration progresses the concentration of the 14-3-2 protein declines so that 6 weeks postoperatively it is only approximately 40% of its control level. On the other hand, there is a slight, but statistically significant, increase in the level of the S-100 protein between the 1st and 4th postoperative weeks which appears to be correlated with the early gliosis in the affected nuclei. On this basis it is suggested that 14-3-2 is primarily a neuronal protein and that the S-100 protein is largely, if not exclusively, confined to glial cells.
AB - An attempt has been made to localize, at a cellular level, the two brain specific proteins, S-100 and 14-3-2, by determining their relative concentrations in thalamic nuclei undergoing retrograde cell degeneration after appropriate lesions of the cerebral cortex. As the neuronal degeneration progresses the concentration of the 14-3-2 protein declines so that 6 weeks postoperatively it is only approximately 40% of its control level. On the other hand, there is a slight, but statistically significant, increase in the level of the S-100 protein between the 1st and 4th postoperative weeks which appears to be correlated with the early gliosis in the affected nuclei. On this basis it is suggested that 14-3-2 is primarily a neuronal protein and that the S-100 protein is largely, if not exclusively, confined to glial cells.
UR - http://www.scopus.com/inward/record.url?scp=0014952567&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(70)90454-3
DO - 10.1016/0006-8993(70)90454-3
M3 - Article
C2 - 5437369
AN - SCOPUS:0014952567
VL - 18
SP - 25
EP - 34
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -