The cell surface antigen locus, MIC2X, escapes X-inactivation

P. Goodfellow, B. Pym, T. Mohandas, L. J. Shapiro

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    85 Scopus citations


    Recently, it was shown that the cell surface antigen defined by the monoclonal antibody 12E7 is expressed by both the human X and Y chromosomes; the gene loci on the X and Y chromosomes are referred to as MIC2X and MIC2Y, respectively. It was also shown that MIC2X is located in the region Xp22.3→Xpter and MIC2Y is in the region Ypter-Yp1.1. Here, we show that MIC2X escapes X-inactivation on structurally normal and abnormal inactive human X chromosomes.

    Original languageEnglish
    Pages (from-to)777-782
    Number of pages6
    JournalAmerican journal of human genetics
    Issue number4
    StatePublished - Jan 1 1984

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    Goodfellow, P., Pym, B., Mohandas, T., & Shapiro, L. J. (1984). The cell surface antigen locus, MIC2X, escapes X-inactivation. American journal of human genetics, 36(4), 777-782.