The CDC20-APC/SOX2 signaling axis: An achilles' heel for glioblastoma

Amit D. Gujar; Hiroko Yano; Albert H. Kim

doi:10.1080/23723556.2015.1075644

The CDC20-APC/SOX2 signaling axis: An achilles' heel for glioblastoma

Amit D. Gujar, Hiroko Yano, Albert H. Kim

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6 Scopus citations

Abstract

Glioblastoma stem-like cells (GSCs) play a critical role in glioblastoma progression and recurrence. We discuss recent results on the role of the mitotic ubiquitin ligase cell division cycle 20–anaphase-promoting complex (CDC20-APC) in the governance of cardinal GSC functions through a mechanism involving the transcription factor sex-determining region Y-box 2 (SOX2). These findings expand the non-mitotic roles of CDC20-APC with implications for stem cell biology.

Original language	English
Article number	e1075644
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	3
DOIs	https://doi.org/10.1080/23723556.2015.1075644
State	Published - May 3 2016

Keywords

CDC20
CDC20–anaphase-promoting complex
Cancer stem cells
SOX2
glioblastoma
glioblastoma stem-like cells
in vivo tumorigenicity
invasion
self-renewal
tumor-initiating cells

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10.1080/23723556.2015.1075644

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title = "The CDC20-APC/SOX2 signaling axis: An achilles' heel for glioblastoma",

abstract = "Glioblastoma stem-like cells (GSCs) play a critical role in glioblastoma progression and recurrence. We discuss recent results on the role of the mitotic ubiquitin ligase cell division cycle 20–anaphase-promoting complex (CDC20-APC) in the governance of cardinal GSC functions through a mechanism involving the transcription factor sex-determining region Y-box 2 (SOX2). These findings expand the non-mitotic roles of CDC20-APC with implications for stem cell biology.",

keywords = "CDC20, CDC20–anaphase-promoting complex, Cancer stem cells, SOX2, glioblastoma, glioblastoma stem-like cells, in vivo tumorigenicity, invasion, self-renewal, tumor-initiating cells",

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AU - Yano, Hiroko

AU - Kim, Albert H.

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AB - Glioblastoma stem-like cells (GSCs) play a critical role in glioblastoma progression and recurrence. We discuss recent results on the role of the mitotic ubiquitin ligase cell division cycle 20–anaphase-promoting complex (CDC20-APC) in the governance of cardinal GSC functions through a mechanism involving the transcription factor sex-determining region Y-box 2 (SOX2). These findings expand the non-mitotic roles of CDC20-APC with implications for stem cell biology.

KW - CDC20

KW - CDC20–anaphase-promoting complex

KW - Cancer stem cells

KW - SOX2

KW - glioblastoma

KW - glioblastoma stem-like cells

KW - in vivo tumorigenicity

KW - invasion

KW - self-renewal

KW - tumor-initiating cells

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ER -

The CDC20-APC/SOX2 signaling axis: An achilles' heel for glioblastoma

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