The CDC20-APC/SOX2 signaling axis: An achilles' heel for glioblastoma

Amit D. Gujar, Hiroko Yano, Albert H. Kim

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Glioblastoma stem-like cells (GSCs) play a critical role in glioblastoma progression and recurrence. We discuss recent results on the role of the mitotic ubiquitin ligase cell division cycle 20–anaphase-promoting complex (CDC20-APC) in the governance of cardinal GSC functions through a mechanism involving the transcription factor sex-determining region Y-box 2 (SOX2). These findings expand the non-mitotic roles of CDC20-APC with implications for stem cell biology.

Original languageEnglish
Article numbere1075644
JournalMolecular and Cellular Oncology
Volume3
Issue number3
DOIs
StatePublished - May 3 2016

Keywords

  • CDC20
  • CDC20–anaphase-promoting complex
  • Cancer stem cells
  • SOX2
  • glioblastoma
  • glioblastoma stem-like cells
  • in vivo tumorigenicity
  • invasion
  • self-renewal
  • tumor-initiating cells

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