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The CCL2/CCR2 axis is critical to recruiting macrophages into acellular nerve allograft bridging a nerve gap to promote angiogenesis and regeneration
Deng Pan
, Jesús A. Acevedo-Cintrón
, Junichi Sayanagi
, Alison K. Snyder-Warwick
,
Susan E. Mackinnon
,
Matthew D. Wood
Division of Plastic and Reconstructive Surgery
Institute of Clinical and Translational Sciences (ICTS)
Center of Regenerative Medicine
Roy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)
DBBS - Neurosciences
DBBS - Developmental, Regenerative and Stem Cell Biology
DBBS - Molecular Cell Biology
Hope Center for Neurological Disorders
Research output
:
Contribution to journal
›
Article
›
peer-review
41
Scopus citations
Overview
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Keyphrases
Macrophages
100%
Angiogenesis
100%
Regeneration
100%
CCR2
100%
Processed Nerve Allograft
100%
Nerve Gap
100%
Chemokine (C-C motif) Ligand 2 (CCL2)
100%
Nerve Regeneration
41%
Wild Mice
16%
Hematogenous
16%
Impaired Angiogenesis
16%
Cell Repopulation
16%
Knock-in Mouse Model
8%
Mouse Model
8%
Neutrophils
8%
Receptor Signaling
8%
Acellular
8%
Nerve Autograft
8%
Major Contributor
8%
Vascular Endothelial Growth Factor Receptor (VEGFR)
8%
Cell Recruitment
8%
Nerve
8%
Reinforced
8%
Functional Regeneration
8%
Regenerability
8%
Axonal Extension
8%
Nerve Recovery
8%
Macrophage Recruitment
8%
Repopulation
8%
Regenerative Mechanism
8%
Improved Design
8%
Nerve Scaffold
8%
Neuroscience
Macrophage
100%
Angiogenesis
100%
CCR2
100%
CCL2
100%
Nervous System Regeneration
50%
VEGF Receptors
10%
Axon
10%