TY - JOUR
T1 - The Canonical Notch Signaling Pathway
T2 - Unfolding the Activation Mechanism
AU - Kopan, Raphael
AU - Ilagan, Ma Xenia G.
N1 - Funding Information:
We are grateful to C. Micchelli, T. Schedl, J. Skeath, M. Vooijs, and the reviewers for their critical reading of this manuscript. We also thank A. Hart, W. Zhong, and the Ingenium Corporation for discussing unpublished results and members of the Kopan lab for helpful discussions. Our research on Notch signaling is supported by National Institutes of Health grants GM55479 (R.K.) and R21-NS06168001 (M.X.G.I.).
PY - 2009/4/17
Y1 - 2009/4/17
N2 - Notch signaling regulates many aspects of metazoan development and tissue renewal. Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human disorders, from developmental syndromes to adult-onset diseases and cancer. Notch signaling is remarkably robust in most tissues even though each Notch molecule is irreversibly activated by proteolysis and signals only once without amplification by secondary messenger cascades. In this Review, we highlight recent studies in Notch signaling that reveal new molecular details about the regulation of ligand-mediated receptor activation, receptor proteolysis, and target selection.
AB - Notch signaling regulates many aspects of metazoan development and tissue renewal. Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human disorders, from developmental syndromes to adult-onset diseases and cancer. Notch signaling is remarkably robust in most tissues even though each Notch molecule is irreversibly activated by proteolysis and signals only once without amplification by secondary messenger cascades. In this Review, we highlight recent studies in Notch signaling that reveal new molecular details about the regulation of ligand-mediated receptor activation, receptor proteolysis, and target selection.
UR - http://www.scopus.com/inward/record.url?scp=64249172203&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2009.03.045
DO - 10.1016/j.cell.2009.03.045
M3 - Review article
C2 - 19379690
AN - SCOPUS:64249172203
SN - 0092-8674
VL - 137
SP - 216
EP - 233
JO - Cell
JF - Cell
IS - 2
ER -