The cancer genome atlas pan-cancer analysis project

John N. Weinstein, Eric A. Collisson, Gordon B. Mills, Kenna R.Mills Shaw, Brad A. Ozenberger, Kyle Ellrott, Chris Sander, Joshua M. Stuart, Kyle Chang, Chad J. Creighton, Caleb Davis, Lawrence Donehower, Jennifer Drummond, David Wheeler, Adrian Ally, Miruna Balasundaram, Inanc Birol, Yaron S.N. Butterfield, Andy Chu, Eric ChuahHye Jung E. Chun, Noreen Dhalla, Ranabir Guin, Martin Hirst, Carrie Hirst, Robert A. Holt, Steven J.M. Jones, Darlene Lee, Haiyan I. Li, Marco A. Marra, Michael Mayo, Richard A. Moore, Andrew J. Mungall, A. Gordon Robertson, Jacqueline E. Schein, Payal Sipahimalani, Angela Tam, Nina Thiessen, Richard J. Varhol, Rameen Beroukhim, Ami S. Bhatt, Angela N. Brooks, Andrew D. Cherniack, Samuel S. Freeman, Stacey B. Gabriel, Elena Helman, Joonil Jung, Matthew Meyerson, Akinyemi I. Ojesina, Chandra Sekhar Pedamallu, Gordon Saksena, Steven E. Schumacher, Barbara Tabak, Travis Zack, Eric S. Lander, Christopher A. Bristow, Angela Hadjipanayis, Psalm Haseley, Raju Kucherlapati, Semin Lee, Eunjung Lee, Lovelace J. Luquette, Harshad S. Mahadeshwar, Angeliki Pantazi, Michael Parfenov, Peter J. Park, Alexei Protopopov, Xiaojia Ren, Netty Santoso, Jonathan Seidman, Sahil Seth, Xingzhi Song, Jiabin Tang, Ruibin Xi, Andrew W. Xu, Lixing Yang, Dong Zeng, J. Todd Auman, Saianand Balu, Elizabeth Buda, Cheng Fan, Katherine A. Hoadley, Corbin D. Jones, Shaowu Meng, Piotr A. Mieczkowski, Joel S. Parker, Charles M. Perou, Jeffrey Roach, Yan Shi, Grace O. Silva, Donghui Tan, Umadevi Veluvolu, Scot Waring, Matthew D. Wilkerson, Junyuan Wu, Wei Zhao, Tom Bodenheimer, D. Neil Hayes, Alan P. Hoyle, Stuart R. Jeffreys, Lisle E. Mose, Janae V. Simons, Mathew G. Soloway, Stephen B. Baylin, Benjamin P. Berman, Moiz S. Bootwalla, Ludmila Danilova, James G. Herman, Toshinori Hinoue, Peter W. Laird, Suhn K. Rhie, Hui Shen, Timothy Triche, Daniel J. Weisenberger, Scott L. Carter, Kristian Cibulskis, Lynda Chin, Jianhua Zhang, Carrie Sougnez, Min Wang, Gad Getz, Huyen Dinh, Harsha Vardhan Doddapaneni, Richard Gibbs, Preethi Gunaratne, Yi Han, Divya Kalra, Christie Kovar, Lora Lewis, Margaret Morgan, Donna Morton, Donna Muzny, Jeffrey Reid, Liu Xi, Juok Cho, Daniel Dicara, Scott Frazer, Nils Gehlenborg, David I. Heiman, Jaegil Kim, Michael S. Lawrence, Pei Lin, Yingchun Liu, Michael S. Noble, Petar Stojanov, Doug Voet, Hailei Zhang, Lihua Zou, Chip Stewart, Brady Bernard, Ryan Bressler, Andrea Eakin, Lisa Iype, Theo Knijnenburg, Roger Kramer, Richard Kreisberg, Kalle Leinonen, Jake Lin, Yuexin Liu, Michael Miller, Sheila M. Reynolds, Hector Rovira, Ilya Shmulevich, Vesteinn Thorsson, Da Yang, Wei Zhang, Samirkumar Amin, Chang Jiun Wu, Chia Chin Wu, Rehan Akbani, Kenneth Aldape, Keith A. Baggerly, Bradley Broom, Tod D. Casasent, James Cleland, Deepti Dodda, Mary Edgerton, Leng Han, Shelley M. Herbrich, Zhenlin Ju, Hoon Kim, Seth Lerner, Jun Li, Han Liang, Wenbin Liu, Philip L. Lorenzi, Yiling Lu, James Melott, Lam Nguyen, Xiaoping Su, Roeland Verhaak, Wenyi Wang, Andrew Wong, Yang Yang, Jun Yao, Rong Yao, Kosuke Yoshihara, Yuan Yuan, Alfred K. Yung, Nianxiang Zhang, Siyuan Zheng, Michael Ryan, David W. Kane, B. Arman Aksoy, Giovanni Ciriello, Gideon Dresdner, Jianjiong Gao, Benjamin Gross, Anders Jacobsen, Andre Kahles, Marc Ladanyi, William Lee, Kjong Van Lehmann, Martin L. Miller, Ricardo Ramirez, Gunnar Rätsch, Boris Reva, Nikolaus Schultz, Yasin Senbabaoglu, Ronglai Shen, Rileen Sinha, S. Onur Sumer, Yichao Sun, Barry S. Taylor, Nils Weinhold, Suzanne Fei, Paul Spellman, Christopher Benz, Daniel Carlin, Melisssa Cline, Brian Craft, Mary Goldman, David Haussler, Singer Ma, Sam Ng, Evan Paull, Amie Radenbaugh, Sofie Salama, Artem Sokolov, Teresa Swatloski, Vladislav Uzunangelov, Peter Waltman, Christina Yau, Jing Zhu, Stanley R. Hamilton, Scott Abbott, Rachel Abbott, Nathan D. Dees, Kim Delehaunty, Li Ding, David J. Dooling, Jim M. Eldred, Catrina C. Fronick, Robert Fulton, Lucinda L. Fulton, Joelle Kalicki-Veizer, Krishna Latha Kanchi, Cyriac Kandoth, Daniel C. Koboldt, David E. Larson, Timothy J. Ley, Ling Lin, Charles Lu, Vincent J. Magrini, Elaine R. Mardis, Michael D. McLellan, Joshua F. McMichael, Christopher A. Miller, Michelle O'Laughlin, Craig Pohl, Heather Schmidt, Scott M. Smith, Jason Walker, John W. Wallis, Michael C. Wendl, Richard K. Wilson, Todd Wylie, Qunyuan Zhang, Robert Burton, Mark A. Jensen, Ari Kahn, Todd Pihl, David Pot, Yunhu Wan, Douglas A. Levine, Aaron D. Black, Jay Bowen, Jessica Frick, Julie M. Gastier-Foster, Hollie A. Harper, Carmen Helsel, Kristen M. Leraas, Tara M. Lichtenberg, Cynthia McAllister, Nilsa C. Ramirez, Samantha Sharpe, Lisa Wise, Erik Zmuda, Stephen J. Chanock, Tanja Davidsen, John A. Demchok, Greg Eley, Ina Felau, Margi Sheth, Heidi Sofia, Louis Staudt, Roy Tarnuzzer, Zhining Wang, Liming Yang, Jiashan Zhang, Larsson Omberg, Adam Margolin, Benjamin J. Raphael, Fabio Vandin, Hsin Ta Wu, Mark D.M. Leiserson, Stephen C. Benz, Charles J. Vaske, Houtan Noushmehr, Denise Wolf, Laura Van T. Veer, Dimitris Anastassiou, Tai Hsien Ou Yang, Nuria Lopez-Bigas, Abel Gonzalez-Perez, David Tamborero, Zheng Xia, Wei Li, Dong Yeon Cho, Teresa Przytycka, Mark Hamilton, Sean McGuire, Sven Nelander, Patrik Johansson, Rebecka Jörnsten, Teresia Kling

Research output: Contribution to journalArticlepeer-review

5585 Scopus citations

Abstract

The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile.

Original languageEnglish
Pages (from-to)1113-1120
Number of pages8
JournalNature Genetics
Volume45
Issue number10
DOIs
StatePublished - Oct 1 2013

Fingerprint

Dive into the research topics of 'The cancer genome atlas pan-cancer analysis project'. Together they form a unique fingerprint.

Cite this