The C523A β2 adrenergic receptor polymorphism associates with markers of asthma severity in African Americans

John J. Lima; Janet T. Holbrook; Jianwei Wang; James E. Sylvester; Kathryn V. Blake; Malcolm N. Blumenthal; Mario Castro; Nicholas Hanania; Robert Wise

doi:10.1080/02770900600566611

The C523A β₂ adrenergic receptor polymorphism associates with markers of asthma severity in African Americans

John J. Lima, Janet T. Holbrook, Jianwei Wang, James E. Sylvester, Kathryn V. Blake, Malcolm N. Blumenthal, Mario Castro, Nicholas Hanania, Robert Wise

Division of Pulmonary & Critical Care Medicine

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Our goal was to explore associations between β₂ adrenergic receptor polymorphisms and markers of asthma severity in African American and Caucasian patients with asthma. Polymorphisms at loci -1023, -654, -47, 46, 79, 491, and 523 were genotyped and haplotypes were imputed in 143 African Americans and 336 Caucasians. C523A genotype associated with percentage of African Americans (but not of Caucasians) having an asthma exacerbation: AA, AC, and CC genotypes were 17, 29, and 40%, respectively ( p = 0.018). Symptom scores, pulmonary function, and rescue inhaler use paralleled exacerbation prevalence. We conclude the 523 A allele modifies asthma severity in African Americans.

Original language	English
Pages (from-to)	185-191
Number of pages	7
Journal	Journal of Asthma
Volume	43
Issue number	3
DOIs	https://doi.org/10.1080/02770900600566611
State	Published - 2006

Keywords

Asthma severity
Polymorphisms
Race
β adrenergic receptor

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10.1080/02770900600566611

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title = "The C523A β2 adrenergic receptor polymorphism associates with markers of asthma severity in African Americans",

abstract = "Our goal was to explore associations between β2 adrenergic receptor polymorphisms and markers of asthma severity in African American and Caucasian patients with asthma. Polymorphisms at loci -1023, -654, -47, 46, 79, 491, and 523 were genotyped and haplotypes were imputed in 143 African Americans and 336 Caucasians. C523A genotype associated with percentage of African Americans (but not of Caucasians) having an asthma exacerbation: AA, AC, and CC genotypes were 17, 29, and 40%, respectively ( p = 0.018). Symptom scores, pulmonary function, and rescue inhaler use paralleled exacerbation prevalence. We conclude the 523 A allele modifies asthma severity in African Americans.",

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author = "Lima, {John J.} and Holbrook, {Janet T.} and Jianwei Wang and Sylvester, {James E.} and Blake, {Kathryn V.} and Blumenthal, {Malcolm N.} and Mario Castro and Nicholas Hanania and Robert Wise",

note = "Funding Information: Supported by the American Lung Association, Nemours Research Foundation.",

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T1 - The C523A β2 adrenergic receptor polymorphism associates with markers of asthma severity in African Americans

AU - Lima, John J.

AU - Holbrook, Janet T.

AU - Wang, Jianwei

AU - Sylvester, James E.

AU - Blake, Kathryn V.

AU - Blumenthal, Malcolm N.

AU - Castro, Mario

AU - Hanania, Nicholas

AU - Wise, Robert

N1 - Funding Information: Supported by the American Lung Association, Nemours Research Foundation.

PY - 2006

Y1 - 2006

N2 - Our goal was to explore associations between β2 adrenergic receptor polymorphisms and markers of asthma severity in African American and Caucasian patients with asthma. Polymorphisms at loci -1023, -654, -47, 46, 79, 491, and 523 were genotyped and haplotypes were imputed in 143 African Americans and 336 Caucasians. C523A genotype associated with percentage of African Americans (but not of Caucasians) having an asthma exacerbation: AA, AC, and CC genotypes were 17, 29, and 40%, respectively ( p = 0.018). Symptom scores, pulmonary function, and rescue inhaler use paralleled exacerbation prevalence. We conclude the 523 A allele modifies asthma severity in African Americans.

AB - Our goal was to explore associations between β2 adrenergic receptor polymorphisms and markers of asthma severity in African American and Caucasian patients with asthma. Polymorphisms at loci -1023, -654, -47, 46, 79, 491, and 523 were genotyped and haplotypes were imputed in 143 African Americans and 336 Caucasians. C523A genotype associated with percentage of African Americans (but not of Caucasians) having an asthma exacerbation: AA, AC, and CC genotypes were 17, 29, and 40%, respectively ( p = 0.018). Symptom scores, pulmonary function, and rescue inhaler use paralleled exacerbation prevalence. We conclude the 523 A allele modifies asthma severity in African Americans.

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The C523A β₂ adrenergic receptor polymorphism associates with markers of asthma severity in African Americans

Abstract

Keywords

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